PMID- 34551608
OWN - NLM
STAT- MEDLINE
DCOM- 20220208
LR  - 20240405
IS  - 1559-7016 (Electronic)
IS  - 0271-678X (Print)
IS  - 0271-678X (Linking)
VI  - 42
IP  - 1
DP  - 2022 Jan
TI  - A review of bioeffects induced by focused ultrasound combined with microbubbles 
      on the neurovascular unit.
PG  - 3-26
LID - 10.1177/0271678X211046129 [doi]
AB  - Focused ultrasound combined with circulating microbubbles (FUS+MB) can 
      transiently enhance blood-brain barrier (BBB) permeability at targeted brain 
      locations. Its great promise in improving drug delivery to the brain is reflected 
      by a rapidly growing number of clinical trials using FUS+MB to treat various 
      brain diseases. As the clinical applications of FUS+MB continue to expand, it is 
      critical to have a better understanding of the molecular and cellular effects 
      induced by FUS+MB to enhance the efficacy of current treatment and enable the 
      discovery of new therapeutic strategies. Existing studies primarily focus on 
      FUS+MB-induced effects on brain endothelial cells, the major cellular component 
      of BBB. However, bioeffects induced by FUS+MB expand beyond the BBB to cells 
      surrounding blood vessels, including astrocytes, microglia, and neurons. Together 
      these cell types comprise the neurovascular unit (NVU). In this review, we 
      examine cell-type-specific bioeffects of FUS+MB on different NVU components, 
      including enhanced permeability in endothelial cells, activation of astrocytes 
      and microglia, as well as increased intraneuron protein metabolism and neuronal 
      activity. Finally, we discuss knowledge gaps that must be addressed to further 
      advance clinical applications of FUS+MB.
FAU - Chen, Si
AU  - Chen S
AD  - Department of Biomedical Engineering, Washington University in St. Louis, Saint 
      Louis, MO, USA.
FAU - Nazeri, Arash
AU  - Nazeri A
AD  - Mallinckrodt Institute of Radiology, Washington University School of Medicine, 
      Saint Louis, MO, USA.
FAU - Baek, Hongchae
AU  - Baek H
AD  - Imaging Institute and Neurological Institute, 2569Cleveland Clinic, Cleveland 
      Clinic, Cleveland, OH, USA.
FAU - Ye, Dezhuang
AU  - Ye D
AD  - Department of Biomedical Engineering, Washington University in St. Louis, Saint 
      Louis, MO, USA.
FAU - Yang, Yaoheng
AU  - Yang Y
AD  - Department of Biomedical Engineering, Washington University in St. Louis, Saint 
      Louis, MO, USA.
FAU - Yuan, Jinyun
AU  - Yuan J
AD  - Department of Biomedical Engineering, Washington University in St. Louis, Saint 
      Louis, MO, USA.
FAU - Rubin, Joshua B
AU  - Rubin JB
AD  - Department of Pediatrics, Washington University School of Medicine, Saint Louis, 
      MO, USA.
AD  - Department of Neuroscience, Washington University School of Medicine, Saint 
      Louis, MO, USA.
FAU - Chen, Hong
AU  - Chen H
AD  - Department of Biomedical Engineering, Washington University in St. Louis, Saint 
      Louis, MO, USA.
AD  - Department of Radiation Oncology, Washington University School of Medicine, Saint 
      Louis, MO, USA.
LA  - eng
GR  - R01 EB027223/EB/NIBIB NIH HHS/United States
GR  - R01 EB030102/EB/NIBIB NIH HHS/United States
GR  - R01 MH116981/MH/NIMH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20210922
PL  - United States
TA  - J Cereb Blood Flow Metab
JT  - Journal of cerebral blood flow and metabolism : official journal of the 
      International Society of Cerebral Blood Flow and Metabolism
JID - 8112566
SB  - IM
MH  - Blood-Brain Barrier/*metabolism
MH  - *Drug Delivery Systems
MH  - Endothelial Cells/metabolism
MH  - Humans
MH  - Microbubbles/*therapeutic use
PMC - PMC8721781
OTO - NOTNLM
OT  - Focused ultrasound
OT  - blood-brain barrier
OT  - cellular effects
OT  - molecular effects
OT  - neurovascular unit
COIS- Declaration of conflicting interests: The author(s) declared no potential 
      conflicts of interest with respect to the research, authorship, and/or 
      publication of this article.
EDAT- 2021/09/24 06:00
MHDA- 2022/02/09 06:00
PMCR- 2022/09/22
CRDT- 2021/09/23 05:31
PHST- 2021/09/24 06:00 [pubmed]
PHST- 2022/02/09 06:00 [medline]
PHST- 2021/09/23 05:31 [entrez]
PHST- 2022/09/22 00:00 [pmc-release]
AID - 10.1177_0271678X211046129 [pii]
AID - 10.1177/0271678X211046129 [doi]
PST - ppublish
SO  - J Cereb Blood Flow Metab. 2022 Jan;42(1):3-26. doi: 10.1177/0271678X211046129. 
      Epub 2021 Sep 22.