PMID- 34551658
OWN - NLM
STAT- MEDLINE
DCOM- 20211208
LR  - 20211214
IS  - 1941-9260 (Electronic)
IS  - 0032-5481 (Linking)
VI  - 133
IP  - 8
DP  - 2021 Nov
TI  - Impact of chronic medications in the perioperative period -anesthetic 
      implications (Part II).
PG  - 920-938
LID - 10.1080/00325481.2021.1982298 [doi]
AB  - Background: This review article discusses the pharmacodynamic effects of the most 
      commonly used chronic medications by patients undergoing elective surgical 
      procedures, namely cardiovascular drugs (e.g., beta blockers, alpha-2 agonist, 
      calcium channel blockers, ACE inhibitors, diuretics, etc.), lipid-lowering drugs, 
      gastrointestinal medications (H2-blockers, proton pump inhibitors), pulmonary 
      medications (inhaled beta-agonists, anticholinergics,), antibiotics (tetracyclines, 
      clindamycin and macrolide, linezolid.), opioids and non-opioids analgesics 
      (NSAIDs, COX-2 inhibitors, acetaminophen), gabapentanoids, erectile dysfunction 
      (ED) drugs, psychotropic drugs (tricyclic antidepressants [TCAs], monoamine 
      oxidase inhibitors [MAOI], selective serotonin reuptake inhibitors [SSRIs], 
      serotonin norepinephrine reuptake inhibitors [SNRIs], and cannabinol-containing 
      drugs).  In addition, the potential adverse drug-interactions between these 
      chronic medications and commonly used anesthetic drugs during the perioperative 
      period will be reviewed. Finally, recommendations regarding the management of 
      chronic medications during the preoperative period will be provided.Materials and 
      Methods: An online search was conducted from January 2000 through February 2021 
      with the Medline database through PubMed and Google Scholar using the following 
      search terms/keywords: "chronic medications in the perioperative period", and 
      "chronic medications and anesthetic implications." In addition, we searched for 
      anesthetic side effects associated with the major drug groups.Results and 
      Conclusions: An understanding of the pharmacodynamic effects of most used chronic 
      medications is important to avoid untoward outcomes in the perioperative period. 
      These drug interactions may result in altered efficacy and toxicity of the 
      anesthetic medications administered during surgery. These drug-drug interactions 
      can also affect the morbidity, mortality, recovery time of surgical patients and 
      acute relapse of chronic illnesses which could lead to last minute cancellation 
      of surgical procedures. Part II of this two-part review article focuses on the 
      reported interactions between most commonly taken chronic medications by surgical 
      patients and anesthetic and analgesic drugs, as well as recommendations regarding 
      the handling these chronic medications during the perioperative period.
FAU - Elvir-Lazo, Ofelia Loani
AU  - Elvir-Lazo OL
AUID- ORCID: 0000-0002-2825-5182
AD  - Department of Anesthesiology, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
FAU - White, Paul F
AU  - White PF
AUID- ORCID: 0000-0003-2275-819X
AD  - Department of Anesthesiology, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
AD  - The White Mountain Institute, The Sea Ranch, CA, USA.
FAU - Cruz Eng, Hillenn
AU  - Cruz Eng H
AUID- ORCID: 0000-0002-1267-135X
AD  - Adena Health System, department of anesthesiology, Chillicothe, OH, US.
FAU - Yumul, Firuz
AU  - Yumul F
AUID- ORCID: 0000-0003-3353-8467
AD  - Department of family medicine, Skagit Regional Health, Family Medicine, 
      Arlington, WA, USA.
FAU - Chua, Raissa
AU  - Chua R
AUID- ORCID: 0000-0001-9289-1290
AD  - Department of Internal Medicine, Huntington Hospital, Prasadena, CA, USA.
FAU - Yumul, Roya
AU  - Yumul R
AUID- ORCID: 0000-0002-3645-7972
AD  - Department of Anesthesiology, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
AD  - David Geffen School of Medicine-UCLA, Charles R, Drew University of Medicine and 
      Science, Los Angeles, CA, USA.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20210930
PL  - England
TA  - Postgrad Med
JT  - Postgraduate medicine
JID - 0401147
RN  - 0 (Anesthetics)
RN  - 0 (Pharmaceutical Preparations)
SB  - IM
UIN - Postgrad Med. 2021 Nov;133(8):939-952. PMID: 34551662
MH  - Anesthetics/*adverse effects
MH  - Chronic Disease/*drug therapy
MH  - *Drug Interactions
MH  - Drug-Related Side Effects and Adverse Reactions/*etiology
MH  - Humans
MH  - *Perioperative Period
MH  - *Pharmaceutical Preparations
MH  - United States
OTO - NOTNLM
OT  - Chronic medications
OT  - interactions with anesthetic drugs
OT  - peri-perioperative period
OT  - pharmacodynamics
EDAT- 2021/09/24 06:00
MHDA- 2021/12/15 06:00
CRDT- 2021/09/23 05:33
PHST- 2021/09/24 06:00 [pubmed]
PHST- 2021/12/15 06:00 [medline]
PHST- 2021/09/23 05:33 [entrez]
AID - 10.1080/00325481.2021.1982298 [doi]
PST - ppublish
SO  - Postgrad Med. 2021 Nov;133(8):920-938. doi: 10.1080/00325481.2021.1982298. Epub 
      2021 Sep 30.