PMID- 34551662
OWN - NLM
STAT- MEDLINE
DCOM- 20211208
LR  - 20211214
IS  - 1941-9260 (Electronic)
IS  - 0032-5481 (Linking)
VI  - 133
IP  - 8
DP  - 2021 Nov
TI  - Impact of chronic medications in the perioperative period: mechanisms of action 
      and adverse drug effects (Part I).
PG  - 939-952
LID - 10.1080/00325481.2021.1982297 [doi]
AB  - Background: This review article discusses the pharmacology of the most commonly 
      used chronic medications in patients undergoing elective surgical procedures. The 
      mechanism of action and adverse side effects of cardiovascular medications (e.g., 
      beta blockers, alpha-2 agonist, calcium channel blockers, ACE inhibitors, 
      diuretics), lipid-lowering drugs, gastrointestinal medications (H2-blockers, 
      proton pump inhibitors), pulmonary medications (inhaled beta-agonists, 
      anticholinergics,), antibiotics (tetracyclines, clindamycin and macrolide, 
      linezolid), opioids and non-opioids analgesics (NSAIDs, COX-2 inhibitors, 
      acetaminophen), gabapentanoids, erectile dysfunction (ED) drugs, and psychotropic 
      drugs (tricyclic antidepressants [TCAs], monoamine oxidase inhibitors [MAOI], 
      selective serotonin reuptake inhibitors [SSRIs], serotonin norepinephrine 
      reuptake inhibitors [SNRIs], and cannabinol-containing drugs) will be 
      reviewed.Materials and Methods: An online search was conducted from January 2000 
      through February 2021 with the Medline database through PubMed and Google Scholar 
      using the following search terms/keywords: "chronic medications in the 
      perioperative period", and "chronic medications and anesthetic implications." In 
      addition, we searched for anesthetic side effects associated with the major drug 
      groups.Results and Conclusions: An understanding of the pharmacology and 
      pharmacokinetics of most used chronic medications is important to avoid untoward 
      outcomes in the perioperative period. These drug interactions may result in 
      altered efficacy and toxicity of the anesthetic medications administered during 
      surgery. These drug-drug interactions can also effect the morbidity, mortality, 
      and recovery time of surgical patients. Part I of this two-part review article 
      focuses on the mechanisms of action and adverse side effects of the chronic 
      medications most commonly taken by surgical patients in the preoperative period.
FAU - Elvir-Lazo, Ofelia Loani
AU  - Elvir-Lazo OL
AUID- ORCID: 0000-0002-2825-5182
AD  - Department of Anesthesiology, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
FAU - White, Paul F
AU  - White PF
AUID- ORCID: 0000-0003-2275-819X
AD  - Department of Anesthesiology, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
AD  - The White Mountain Institute, The Sea Ranch, CA, USA.
FAU - Cruz Eng, Hillenn
AU  - Cruz Eng H
AUID- ORCID: 0000-0002-1267-135X
AD  - Department of Anesthesiology, Adena Health System, Chillicothe, OH, USA.
FAU - Yumul, Firuz
AU  - Yumul F
AUID- ORCID: 0000-0003-3353-8467
AD  - Skagit Regional Health, Family Medicine, Arlington, WA, USA.
FAU - Chua, Raissa
AU  - Chua R
AUID- ORCID: 0000-0001-9289-1290
AD  - Department of Internal Medicine, Huntington Hospital, Pasadena, CA, USA.
FAU - Yumul, Roya
AU  - Yumul R
AUID- ORCID: 0000-0002-3645-7972
AD  - Department of Anesthesiology, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
AD  - David Geffen School of Medicine-UCLA, Charles R, Drew University of Medicine and 
      Science, Los Angeles, CA, USA.
LA  - eng
PT  - Journal Article
DEP - 20210930
PL  - England
TA  - Postgrad Med
JT  - Postgraduate medicine
JID - 0401147
RN  - 0 (Anesthetics)
RN  - 0 (Pharmaceutical Preparations)
SB  - IM
UOF - Postgrad Med. 2021 Nov;133(8):920-938. PMID: 34551658
MH  - Anesthetics/*adverse effects/*pharmacology
MH  - Chronic Disease/*drug therapy
MH  - *Drug Interactions
MH  - Drug-Related Side Effects and Adverse Reactions/*etiology
MH  - Humans
MH  - *Perioperative Period
MH  - *Pharmaceutical Preparations
MH  - United States
OTO - NOTNLM
OT  - Chronic medications
OT  - adverse side effects
OT  - peri-perioperative period
OT  - pharmacodynamics
EDAT- 2021/09/24 06:00
MHDA- 2021/12/15 06:00
CRDT- 2021/09/23 05:33
PHST- 2021/09/24 06:00 [pubmed]
PHST- 2021/12/15 06:00 [medline]
PHST- 2021/09/23 05:33 [entrez]
AID - 10.1080/00325481.2021.1982297 [doi]
PST - ppublish
SO  - Postgrad Med. 2021 Nov;133(8):939-952. doi: 10.1080/00325481.2021.1982297. Epub 
      2021 Sep 30.