PMID- 34552662
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220817
IS  - 1750-9467 (Print)
VI  - 66
DP  - 2019 Oct
TI  - Injury-related treatments and outcomes in preschool children with autism spectrum 
      disorder: Study to Explore Early Development (SEED).
LID - 10.1016/j.rasd.2019.101413 [doi]
AB  - BACKGROUND: Evidence about injury management and outcomes in children with autism 
      spectrum disorder (ASD) is limited. METHOD: Cross-sectional analyses included 
      children aged 30-68 months with at least one medically attended injury. 
      Standardized diagnostic instruments determined ASD cases. Parent-reported injury 
      treatments and outcomes were examined in ASD cases (n = 224) versus developmental 
      delays/disorders (DD) (n = 188) and population (POP) (n = 267) controls, 
      adjusting for child and family characteristics using logistic regression. 
      RESULTS: Injury characteristics were similar between groups. Most children 
      (82.5%) had emergency care (EC) or hospitalization after injury. Nearly half 
      (46.4%) ever received a medication or injection, mostly analgesics (53.4%) and 
      local anesthetics (23.8%), while 9.4% ever received surgery, most often for open 
      wound (47.0%) or fracture (16.7%). ASD group children were less likely than DD 
      group children to receive medication/injection (41.1% vs. 53.2%, adjusted odds 
      ratio [aOR] = 0.60 [0.40, 0.90]); receipt of EC/hospitalization and surgery were 
      comparable. Children with ASD more often had surgery than POP children (14.3% vs. 
      4.9%, aOR = 2.62 [1.31, 5.25]); receipt of EC/hospitalization and 
      medication/injection were similar. Loss of consciousness was uncommon (ASD = 
      6.3%, DD = 5.3%, POP = 3.4%), as was long-term or significant behavior change 
      (ASD = 5.4%, DD = 3.2%, POP = 3.2%); differences were not significant. 
      CONCLUSIONS: Injured children with ASD received fewer medications/injections than 
      children with non-ASD developmental delays/disorders and more surgical treatments 
      than general population children. Injury management was otherwise similar between 
      groups. Understanding whether these results reflect child or injury 
      characteristics or provider perceptions about behaviors and pain thresholds of 
      children with ASD, and how these may influence care, requires further study.
FAU - DiGuiseppi, Carolyn
AU  - DiGuiseppi C
AD  - University of Colorado Anschutz Medical Campus, Colorado School of Public Health, 
      Department of Epidemiology, Aurora, CO 80045 United States.
FAU - Sabourin, Katherine R
AU  - Sabourin KR
AD  - University of Colorado Anschutz Medical Campus, Colorado School of Public Health, 
      Department of Epidemiology, Aurora, CO 80045 United States.
FAU - Levy, Susan E
AU  - Levy SE
AD  - The Children's Hospital of Philadelphia at University of Pennsylvania, 
      Philadelphia, PA 19104 United States.
FAU - Soke, Gnakub N
AU  - Soke GN
AD  - Centers for Disease Control and Prevention, National Center on Birth Defects and 
      Developmental Disabilities, Atlanta, GA 30341 United States.
FAU - Lee, Li-Ching
AU  - Lee LC
AD  - Johns Hopkins Bloomberg School of Public Health, Department of Epidemiology, 
      Baltimore, MD 21205 United States.
FAU - Wiggins, Lisa
AU  - Wiggins L
AD  - Centers for Disease Control and Prevention, National Center on Birth Defects and 
      Developmental Disabilities, Atlanta, GA 30341 United States.
FAU - Schieve, Laura A
AU  - Schieve LA
AD  - Centers for Disease Control and Prevention, National Center on Birth Defects and 
      Developmental Disabilities, Atlanta, GA 30341 United States.
LA  - eng
GR  - CC999999/ImCDC/Intramural CDC HHS/United States
GR  - U01 DD001210/DD/NCBDD CDC HHS/United States
PT  - Journal Article
PL  - Netherlands
TA  - Res Autism Spectr Disord
JT  - Research in autism spectrum disorders
JID - 101300021
PMC - PMC8455161
MID - NIHMS1629145
OTO - NOTNLM
OT  - ASD
OT  - Emergency care
OT  - Injuries
OT  - Injury outcomes
OT  - Surgery
OT  - Treatment
EDAT- 2019/10/01 00:00
MHDA- 2019/10/01 00:01
PMCR- 2021/09/21
CRDT- 2021/09/23 06:50
PHST- 2021/09/23 06:50 [entrez]
PHST- 2019/10/01 00:00 [pubmed]
PHST- 2019/10/01 00:01 [medline]
PHST- 2021/09/21 00:00 [pmc-release]
AID - 10.1016/j.rasd.2019.101413 [doi]
PST - ppublish
SO  - Res Autism Spectr Disord. 2019 Oct;66:10.1016/j.rasd.2019.101413. doi: 
      10.1016/j.rasd.2019.101413.