PMID- 34553107
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240403
IS  - 2475-0360 (Electronic)
IS  - 2475-0360 (Linking)
VI  - 2
IP  - 4
DP  - 2019 Dec
TI  - Plasma levels of adiponectin and chemerin are associated with early stage of 
      atherosclerosis in older adults with type 2 diabetes mellitus.
PG  - 198-206
LID - 10.1002/agm2.12087 [doi]
AB  - OBJECTIVE: Adipokines, such as adiponectin and chemerin, regulate fat metabolism 
      and are critical for the development of atherosclerosis. Investigating the 
      correlations of adiponectin and chemerin with atherosclerosis in older adults 
      with type 2 diabetes mellitus (T2DM) will shed light on the search for new 
      markers for early diagnosis of diabetic atherosclerosis. METHODS: A total of 120 
      older T2DM patients and nine healthy controls were enrolled in this study. The 
      clinical parameters, such as brachial-ankle pulse wave velocity (ba-PWV), 
      adiponectin, and chemerin, were examined and recorded. T2DM subjects were divided 
      into three groups according to ba-PWV level (high, medium, or low). The data were 
      processed and analyzed by identical methods. RESULTS: Significantly higher 
      chemerin and lower adiponectin levels were detected in the plasma of T2DM 
      patients than in healthy controls. The plasma levels of chemerin and adiponectin 
      were negatively correlated in T2DM patients. Moreover, chemerin and adiponectin 
      were significantly correlated with body mass index, ankle-brachial index, 
      insulin, and ba-PWV. Multiple linear regression analysis revealed that chemerin 
      and adiponectin were independently affecting ba-PWV. CONCLUSION: Adiponectin and 
      chemerin are potential markers for diagnosis and monitoring of early stage of 
      atherosclerosis in older adults with T2DM. Further clinical investigations are 
      required to confirm these markers.
CI  - (c) 2019 The Authors. Aging Medicine published by Beijing Hospital and John Wiley & 
      Sons Australia, Ltd.
FAU - Li, Huahua
AU  - Li H
AUID- ORCID: 0000-0002-5613-7677
AD  - Department of Geriatrics The Hunan Provincial People's Hospital First Affiliated 
      Hospital of Hunan Normal University Changsha China.
FAU - Zhan, Junkun
AU  - Zhan J
AD  - Department of Geriatrics The Second Xiang-Ya Hospital Institute of Aging and 
      Geriatric Research Central South University Changsha China.
FAU - Liao, Bin
AU  - Liao B
AD  - Department of Geriatrics The Hunan Provincial People's Hospital First Affiliated 
      Hospital of Hunan Normal University Changsha China.
FAU - Wang, Yanjiao
AU  - Wang Y
AD  - Department of Geriatrics The Second Xiang-Ya Hospital Institute of Aging and 
      Geriatric Research Central South University Changsha China.
FAU - Liu, Youshuo
AU  - Liu Y
AD  - Department of Geriatrics The Second Xiang-Ya Hospital Institute of Aging and 
      Geriatric Research Central South University Changsha China.
LA  - eng
PT  - Journal Article
DEP - 20191030
PL  - Australia
TA  - Aging Med (Milton)
JT  - Aging medicine (Milton (N.S.W))
JID - 101741954
PMC - PMC8445043
OTO - NOTNLM
OT  - adiponectin
OT  - brachia-ankle pulse wave velocity
OT  - chemerin
OT  - type 2 diabetes mellitus
OT  - vascular stiffness
COIS- Nothing to disclose.
EDAT- 2019/10/30 00:00
MHDA- 2019/10/30 00:01
PMCR- 2019/10/30
CRDT- 2021/09/23 06:56
PHST- 2019/07/31 00:00 [received]
PHST- 2019/09/17 00:00 [revised]
PHST- 2019/09/26 00:00 [accepted]
PHST- 2021/09/23 06:56 [entrez]
PHST- 2019/10/30 00:00 [pubmed]
PHST- 2019/10/30 00:01 [medline]
PHST- 2019/10/30 00:00 [pmc-release]
AID - AGM212087 [pii]
AID - 10.1002/agm2.12087 [doi]
PST - epublish
SO  - Aging Med (Milton). 2019 Oct 30;2(4):198-206. doi: 10.1002/agm2.12087. 
      eCollection 2019 Dec.