PMID- 34554032
OWN - NLM
STAT- MEDLINE
DCOM- 20220428
LR  - 20220607
IS  - 1362-3095 (Electronic)
IS  - 0955-3002 (Linking)
VI  - 98
IP  - 5
DP  - 2022
TI  - A novel oral formulation of BIO 300 confers prophylactic radioprotection from 
      acute radiation syndrome in mice.
PG  - 958-967
LID - 10.1080/09553002.2021.1981556 [doi]
AB  - PURPOSE: Exposure to high doses of ionizing radiation can result in hematopoietic 
      acute radiation syndrome (H-ARS) and delayed effects of acute radiation exposure 
      (DEARE). There is no radiation medical countermeasure (MCM) approved by the U.S. 
      Food and Drug Administration which can be used prior to radiation exposure to 
      protect exposed individuals. Different formulations containing synthetic 
      genistein (BIO 300) are being developed to counter the harmful effects of 
      radiation exposure. MATERIALS AND METHODS: We investigated the efficacy of a BIO 
      300 oral powder (OP) formulation as a prophylactic radiation MCM against a lethal 
      dose of cobalt-60 gamma-radiation in CD2F1 male mice while comparing to other 
      formulations of BIO 300 and Neulasta (PEGylated filgrastim), a standard of care 
      drug for H-ARS. RESULTS: BIO 300 OP provided significant radioprotection against 
      ionizing radiation in mice when administered twice per day for six days prior to 
      total-body radiation exposure. Its radioprotective efficacy in the murine model 
      was comparable to the efficacy of a single subcutaneous (sc) injection of 
      Neulasta administered after total-body radiation exposure. CONCLUSIONS: Our 
      results demonstrate that BIO 300 OP, which can be administered orally, is a 
      promising prophylactic radiation countermeasure for H-ARS.
FAU - Singh, Vijay K
AU  - Singh VK
AUID- ORCID: 0000-0002-6631-3849
AD  - Department of Pharmacology and Molecular Therapeutics, Division of 
      Radioprotectants, F. Edward Hebert School of Medicine, Uniformed Services 
      University of the Health Sciences, Bethesda, MD, USA.
AD  - Armed Forces Radiobiology Research Institute, Uniformed Services University of 
      the Health Sciences, Bethesda, MD, USA.
FAU - Fatanmi, Oluseyi O
AU  - Fatanmi OO
AD  - Department of Pharmacology and Molecular Therapeutics, Division of 
      Radioprotectants, F. Edward Hebert School of Medicine, Uniformed Services 
      University of the Health Sciences, Bethesda, MD, USA.
AD  - Armed Forces Radiobiology Research Institute, Uniformed Services University of 
      the Health Sciences, Bethesda, MD, USA.
FAU - Wise, Stephen Y
AU  - Wise SY
AD  - Department of Pharmacology and Molecular Therapeutics, Division of 
      Radioprotectants, F. Edward Hebert School of Medicine, Uniformed Services 
      University of the Health Sciences, Bethesda, MD, USA.
AD  - Armed Forces Radiobiology Research Institute, Uniformed Services University of 
      the Health Sciences, Bethesda, MD, USA.
FAU - Carpenter, Alana
AU  - Carpenter A
AD  - Department of Pharmacology and Molecular Therapeutics, Division of 
      Radioprotectants, F. Edward Hebert School of Medicine, Uniformed Services 
      University of the Health Sciences, Bethesda, MD, USA.
AD  - Armed Forces Radiobiology Research Institute, Uniformed Services University of 
      the Health Sciences, Bethesda, MD, USA.
FAU - Nakamura-Peek, Sara
AU  - Nakamura-Peek S
AD  - Department of Pharmacology and Molecular Therapeutics, Division of 
      Radioprotectants, F. Edward Hebert School of Medicine, Uniformed Services 
      University of the Health Sciences, Bethesda, MD, USA.
AD  - Armed Forces Radiobiology Research Institute, Uniformed Services University of 
      the Health Sciences, Bethesda, MD, USA.
FAU - Serebrenik, Artur A
AU  - Serebrenik AA
AD  - Humanetics Corporation, Edina, MN, USA.
FAU - Kaytor, Michael D
AU  - Kaytor MD
AD  - Humanetics Corporation, Edina, MN, USA.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210928
PL  - England
TA  - Int J Radiat Biol
JT  - International journal of radiation biology
JID - 8809243
RN  - 0 (Radiation-Protective Agents)
SB  - IM
MH  - *Acute Radiation Syndrome/prevention & control
MH  - Animals
MH  - Dose-Response Relationship, Radiation
MH  - Female
MH  - *Hematopoietic System
MH  - Male
MH  - Mice
MH  - Radiation, Ionizing
MH  - *Radiation-Protective Agents/pharmacology
MH  - Whole-Body Irradiation
OTO - NOTNLM
OT  - Animal model
OT  - BIO 300
OT  - mice
OT  - prophylactic
OT  - radiation
OT  - radioprotection
EDAT- 2021/09/24 06:00
MHDA- 2022/04/29 06:00
CRDT- 2021/09/23 12:16
PHST- 2021/09/24 06:00 [pubmed]
PHST- 2022/04/29 06:00 [medline]
PHST- 2021/09/23 12:16 [entrez]
AID - 10.1080/09553002.2021.1981556 [doi]
PST - ppublish
SO  - Int J Radiat Biol. 2022;98(5):958-967. doi: 10.1080/09553002.2021.1981556. Epub 
      2021 Sep 28.