PMID- 34554156
OWN - NLM
STAT- MEDLINE
DCOM- 20211013
LR  - 20211013
IS  - 1364-5528 (Electronic)
IS  - 0003-2654 (Linking)
VI  - 146
IP  - 20
DP  - 2021 Oct 11
TI  - A high sensitivity electrochemical sensor based on a dual-template molecularly 
      imprinted polymer for simultaneous determination of clenbuterol hydrochloride and 
      ractopamine.
PG  - 6323-6332
LID - 10.1039/d1an01413g [doi]
AB  - A nitrogen-doped Fe-MOF shows a high specific surface area and excellent 
      electrical conductivity after high temperature carbonization. A novel 
      electrochemical sensor based on a N@Fe-MOF@C loaded dual-template molecularly 
      imprinted polymer (DTMIP) modified glassy carbon electrode (GCE) was proposed for 
      the rapid and ultra-sensitive simultaneous detection of clenbuterol hydrochloride 
      (CLB) and ractopamine (RAC). N@Fe-MOF@C combined with a MIP significantly 
      enhanced the electrical signal. Cyclic voltammetry (CV) was used to detect CLB 
      and RAC. The electrochemical polymerization was conducted with O-phenylenediamine 
      as the functional monomer and CLB and RAC as template molecules. The factors 
      affecting the sensor response were optimized. Under the optimal experimental 
      conditions, the CV current response showed a linear range of 10(-12)-8 x 10(-9) M 
      for both CLB and RAC, and the detection limit (LOD) for both CLB and RAC was 3.03 
      x 10(-13) M (S/N = 3). This electrochemical sensing system has high sensitivity, 
      selectivity, excellent reproducibility, repeatability and stability. The 
      recoveries of the actual samples (97.4%-101.2%) and reasonable relative standard 
      deviations (RSDs) (1.06%-3.17%) indicate the practicability of the sensor system. 
      The system has high application value in the rapid detection of CLB and RAC in 
      clenbuterol hydrochloride tablets, human urine and raw pork.
FAU - Li, Xiang
AU  - Li X
AD  - Key Laboratory for Green Processing of Chemical Engineering of Xinjiang Bingtuan, 
      School of Chemistry and Chemical Engineering, Shihezi University, Shihezi, China. 
      bcye@ecust.edu.cn.
FAU - Li, Yangguang
AU  - Li Y
AD  - Key Laboratory for Green Processing of Chemical Engineering of Xinjiang Bingtuan, 
      School of Chemistry and Chemical Engineering, Shihezi University, Shihezi, China. 
      bcye@ecust.edu.cn.
FAU - Yu, Pai
AU  - Yu P
AD  - Key Laboratory for Green Processing of Chemical Engineering of Xinjiang Bingtuan, 
      School of Chemistry and Chemical Engineering, Shihezi University, Shihezi, China. 
      bcye@ecust.edu.cn.
FAU - Tong, Yanbin
AU  - Tong Y
AD  - Key Laboratory for Green Processing of Chemical Engineering of Xinjiang Bingtuan, 
      School of Chemistry and Chemical Engineering, Shihezi University, Shihezi, China. 
      bcye@ecust.edu.cn.
FAU - Ye, Bang-Ce
AU  - Ye BC
AUID- ORCID: 0000-0002-5555-5359
AD  - Key Laboratory for Green Processing of Chemical Engineering of Xinjiang Bingtuan, 
      School of Chemistry and Chemical Engineering, Shihezi University, Shihezi, China. 
      bcye@ecust.edu.cn.
AD  - Institute of Engineering Biology and Health, Collaborative Innovation Center of 
      Yangtze River Delta Region Green Pharmaceuticals, College of Pharmaceutical 
      Sciences, Zhejiang University of Technology, Hangzhou 310014, Zhejiang, China.
LA  - eng
PT  - Journal Article
DEP - 20211011
PL  - England
TA  - Analyst
JT  - The Analyst
JID - 0372652
RN  - 0 (Molecularly Imprinted Polymers)
RN  - 0 (Phenethylamines)
RN  - 57370OZ3P1 (ractopamine)
RN  - XTZ6AXU7KN (Clenbuterol)
SB  - IM
MH  - *Clenbuterol
MH  - Electrochemical Techniques
MH  - Electrodes
MH  - Humans
MH  - Limit of Detection
MH  - *Molecular Imprinting
MH  - Molecularly Imprinted Polymers
MH  - Phenethylamines
MH  - Reproducibility of Results
EDAT- 2021/09/24 06:00
MHDA- 2021/10/14 06:00
CRDT- 2021/09/23 12:20
PHST- 2021/09/24 06:00 [pubmed]
PHST- 2021/10/14 06:00 [medline]
PHST- 2021/09/23 12:20 [entrez]
AID - 10.1039/d1an01413g [doi]
PST - epublish
SO  - Analyst. 2021 Oct 11;146(20):6323-6332. doi: 10.1039/d1an01413g.