PMID- 34555503
OWN - NLM
STAT- MEDLINE
DCOM- 20220217
LR  - 20220217
IS  - 1878-5492 (Electronic)
IS  - 0966-3274 (Linking)
VI  - 69
DP  - 2021 Dec
TI  - Diversity of HLA class I and class II alleles in Iran populations: Systematic 
      review and Meta-Analaysis.
PG  - 101472
LID - S0966-3274(21)00112-X [pii]
LID - 10.1016/j.trim.2021.101472 [doi]
AB  - The human leukocyte antigen (HLA) system plays an essential role in the peptides 
      antigen presentation and more regulation of immune responses. Regarding all HLA 
      molecules' associations with various diseases and their clinical utilities in 
      understanding drug reactions or prediction of transplantation outcome, there is a 
      need for much more extensive HLA data generated from Asian countries. METHOD: A 
      comprehensive search was conducted in electronic databases between 1990 and 2021 
      to identify relevant articles to HLA frequency in the normal Iranian population. 
      Two independent reviewers screened and selected the eligible studies. After data 
      extraction, the meta-analysis was performed using STATA version 14. The overall 
      frequencies and their 95% confidence intervals (CIs) were obtained using the 
      random-effects model. RESULTS: Among 1141 studies 78 were eligible for this study 
      and the sample sizes varied from 14 to 15,600. The most frequent alleles of HLA 
      class I were HLA-A*02 (22%; 95%CI: 20-24%; I(2) = 88.63%), -B*35 (18%; 95%CI: 
      16-21%; I(2) = 90.95%), -C*12 (18%; 95%CI: 13-22%; I(2) = 89.51%). HLA-DQA1*01 
      (42%; 95%CI: 40-44%; I(2) = 56.80%), -DQB1*03 (38%; 95%CI: 35-42%; 
      I(2) = 92.38%), and -DRB1*11 (24%; 95%CI: 22-26%; I(2) = 90.72%) were the most 
      frequent alleles of HLA class II in Iran. DISCUSSION: Our meta-analysis results 
      point out that the comprehensive report of HLA allele frequency in the Iranian 
      population could be helpful as reference data for planning and managing 
      transplantation and immune disease treatment in Iran.
CI  - Copyright (c) 2021 Elsevier B.V. All rights reserved.
FAU - Abedini, Fateme
AU  - Abedini F
AD  - Cancer Prevention Research Center, Isfahan University of Medical Sciences, 
      Isfahan, Iran.
FAU - Rahmanian, Narges
AU  - Rahmanian N
AD  - Cancer Prevention Research Center, Isfahan University of Medical Sciences, 
      Isfahan, Iran; Applied Physiology Research Center, Cardiovascular Research 
      Institute, Isfahan University of Medical Sciences, Isfahan, Iran.
FAU - Heidari, Zahra
AU  - Heidari Z
AD  - Department of Biostatistics and Epidemiology, School of Health, Isfahan 
      University of Medical sciences, Isfahan, Iran.
FAU - Feizi, Awat
AU  - Feizi A
AD  - Department of Biostatistics and Epidemiology, School of Health, Isfahan 
      University of Medical sciences, Isfahan, Iran.
FAU - Sherkat, Roya
AU  - Sherkat R
AD  - Acquired Immunodeficiency Research Center, Isfahan University of Medical 
      Sciences, Isfahan, Iran.
FAU - Rezaei, Marzieh
AU  - Rezaei M
AD  - Department of Immunology, School of Medicine, Isfahan University of Medical 
      Sciences, Isfahan, Iran. Electronic address: ma.rezaei@med.mui.ac.ir.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Systematic Review
DEP - 20210920
PL  - Netherlands
TA  - Transpl Immunol
JT  - Transplant immunology
JID - 9309923
RN  - 0 (HLA-DRB1 Chains)
RN  - 0 (Histocompatibility Antigens Class I)
SB  - IM
MH  - Alleles
MH  - Gene Frequency
MH  - HLA-DRB1 Chains/genetics
MH  - Haplotypes
MH  - *Histocompatibility Antigens Class I/genetics
MH  - Humans
MH  - Iran
OTO - NOTNLM
OT  - Frequency
OT  - Human leukocyte antigen
OT  - Iran
OT  - meta-analysis
EDAT- 2021/09/24 06:00
MHDA- 2022/02/19 06:00
CRDT- 2021/09/23 20:14
PHST- 2021/08/21 00:00 [received]
PHST- 2021/09/16 00:00 [revised]
PHST- 2021/09/16 00:00 [accepted]
PHST- 2021/09/24 06:00 [pubmed]
PHST- 2022/02/19 06:00 [medline]
PHST- 2021/09/23 20:14 [entrez]
AID - S0966-3274(21)00112-X [pii]
AID - 10.1016/j.trim.2021.101472 [doi]
PST - ppublish
SO  - Transpl Immunol. 2021 Dec;69:101472. doi: 10.1016/j.trim.2021.101472. Epub 2021 
      Sep 20.