PMID- 34555793 OWN - NLM STAT- MEDLINE DCOM- 20211105 LR - 20211105 IS - 1873-6424 (Electronic) IS - 0269-7491 (Linking) VI - 291 DP - 2021 Dec 15 TI - Biomonitoring of 89 POPs in blood serum samples of Czech city policemen. PG - 118140 LID - S0269-7491(21)01722-X [pii] LID - 10.1016/j.envpol.2021.118140 [doi] AB - In this biomonitoring study, we evaluated the concentrations of 8 polychlorinated biphenyls (PCBs), 11 organochlorinated pesticides (OCPs), 33 brominated flame retardants (BFRs), 7 novel brominated and chlorinated flame retardants (novel FRs) and 30 per- and polyfluoroalkylated substances (PFAS) in human serum samples (n = 274). A total of 89 persistent organic pollutants (POPs) were measured in blood serum samples of city policemen living in three large cities and their adjacent areas (Ostrava, Prague, and Ceske Budejovice) in the Czech Republic. All samples were collected during the year 2019 in two sampling periods (spring and autumn). The identification/quantification of PCBs, OCPs, BFRs, novel FRs and PFAS was performed by means of gas chromatography coupled to (tandem) mass spectrometry (GC-MS/(MS)) and ultra-high performance liquid chromatography coupled to triple quadrupole tandem mass spectrometry (UHPLC-MS/MS). The most frequently detected pollutants were perfluorooctanoic acid (PFOA), perfluorononanoic acid (PFNA), perfluorodecanoic acid (PFDA), perfluorooctanesulfonate (PFOS), perfluorohexanesulfonate (PFHxS), 2,2',3,4,4',5'-hexachlorobiphenyl (CB 138), 2,2',4,4',5,5'-hexachlorobiphenyl (CB 153), 2,2',3,3',4,4',5-heptachlorobiphenyl (CB 170), 2,2',3,4,4',5,5'-heptachlorobiphenyl (CB 180), hexachlorobenzene (HCB), and p,p'-dichlorodiphenyldichloroethylene (p,p'-DDE) quantified in 100% of serum samples. In the serum samples, the concentrations of determined POPs were in the range of 0.108-900 ng g(-1) lipid weight (lw) for PCBs, 0.106-1016 ng g(-1) lw for OCPs, <0.1-618 ng g(-1) lw for FRs and <0.01-18.3 ng mL(-1) for PFAS, respectively. Locality, sampling season, and age were significantly associated with several POP concentrations. One of the important conclusions was that within the spring sampling period, statistically significant higher concentrations of CB 170 and CB 180 were observed in the samples from Ostrava (industrial area) compared to Prague and Ceske Budejovice. Older policemen had higher concentrations of five PCBs and two OCPs in blood serum. CI - Copyright (c) 2021 The Authors. Published by Elsevier Ltd.. All rights reserved. FAU - Polachova, Andrea AU - Polachova A AD - University of Chemistry and Technology, Prague, Faculty of Food and Biochemical Technology, Department of Food Analysis and Nutrition, Technicka 3, 166 28, Prague 6, Czech Republic. FAU - Gramblicka, Tomas AU - Gramblicka T AD - University of Chemistry and Technology, Prague, Faculty of Food and Biochemical Technology, Department of Food Analysis and Nutrition, Technicka 3, 166 28, Prague 6, Czech Republic. FAU - Bechynska, Kamila AU - Bechynska K AD - University of Chemistry and Technology, Prague, Faculty of Food and Biochemical Technology, Department of Food Analysis and Nutrition, Technicka 3, 166 28, Prague 6, Czech Republic. FAU - Parizek, Ondrej AU - Parizek O AD - University of Chemistry and Technology, Prague, Faculty of Food and Biochemical Technology, Department of Food Analysis and Nutrition, Technicka 3, 166 28, Prague 6, Czech Republic. FAU - Parizkova, Denisa AU - Parizkova D AD - University of Chemistry and Technology, Prague, Faculty of Food and Biochemical Technology, Department of Food Analysis and Nutrition, Technicka 3, 166 28, Prague 6, Czech Republic. FAU - Dvorakova, Darina AU - Dvorakova D AD - University of Chemistry and Technology, Prague, Faculty of Food and Biochemical Technology, Department of Food Analysis and Nutrition, Technicka 3, 166 28, Prague 6, Czech Republic. FAU - Honkova, Katerina AU - Honkova K AD - Institute of Experimental Medicine of the Czech Academy of Sciences, Department of Genetic Toxicology and Epigenetics, Videnska 1083, 142 20, Prague 4, Czech Republic. FAU - Rossnerova, Andrea AU - Rossnerova A AD - Institute of Experimental Medicine of the Czech Academy of Sciences, Department of Genetic Toxicology and Epigenetics, Videnska 1083, 142 20, Prague 4, Czech Republic. FAU - Rossner, Pavel AU - Rossner P AD - Institute of Experimental Medicine of the Czech Academy of Sciences, Department of Nanotoxicology and Molecular Epidemiology Videnska 1083, 142 20, Prague 4, Czech Republic. FAU - Sram, Radim J AU - Sram RJ AD - Institute of Experimental Medicine of the Czech Academy of Sciences, Department of Genetic Toxicology and Epigenetics, Videnska 1083, 142 20, Prague 4, Czech Republic. FAU - Topinka, Jan AU - Topinka J AD - Institute of Experimental Medicine of the Czech Academy of Sciences, Department of Genetic Toxicology and Epigenetics, Videnska 1083, 142 20, Prague 4, Czech Republic. FAU - Pulkrabova, Jana AU - Pulkrabova J AD - University of Chemistry and Technology, Prague, Faculty of Food and Biochemical Technology, Department of Food Analysis and Nutrition, Technicka 3, 166 28, Prague 6, Czech Republic. Electronic address: jana.pulkrabova@vscht.cz. LA - eng PT - Journal Article DEP - 20210910 PL - England TA - Environ Pollut JT - Environmental pollution (Barking, Essex : 1987) JID - 8804476 RN - 0 (Environmental Pollutants) RN - 0 (Hydrocarbons, Chlorinated) RN - 0 (Pesticides) RN - DFC2HB4I0K (Polychlorinated Biphenyls) SB - IM MH - Biological Monitoring MH - Cities MH - Czech Republic MH - Environmental Monitoring MH - *Environmental Pollutants/analysis MH - Gas Chromatography-Mass Spectrometry MH - Humans MH - *Hydrocarbons, Chlorinated/analysis MH - *Pesticides/analysis MH - *Polychlorinated Biphenyls/analysis MH - Serum/chemistry MH - Tandem Mass Spectrometry OTO - NOTNLM OT - City policemen OT - Czech Republic OT - Human biomonitoring OT - POPs OT - Serum EDAT- 2021/09/24 06:00 MHDA- 2021/11/06 06:00 CRDT- 2021/09/23 20:30 PHST- 2021/05/21 00:00 [received] PHST- 2021/08/20 00:00 [revised] PHST- 2021/09/06 00:00 [accepted] PHST- 2021/09/24 06:00 [pubmed] PHST- 2021/11/06 06:00 [medline] PHST- 2021/09/23 20:30 [entrez] AID - S0269-7491(21)01722-X [pii] AID - 10.1016/j.envpol.2021.118140 [doi] PST - ppublish SO - Environ Pollut. 2021 Dec 15;291:118140. doi: 10.1016/j.envpol.2021.118140. Epub 2021 Sep 10.