PMID- 34557035
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220426
IS  - 1178-7090 (Print)
IS  - 1178-7090 (Electronic)
IS  - 1178-7090 (Linking)
VI  - 14
DP  - 2021
TI  - Common and Contrasting Characteristics of the Chronic Soft-Tissue Pain Conditions 
      Fibromyalgia and Lipedema.
PG  - 2931-2941
LID - 10.2147/JPR.S315736 [doi]
AB  - OBJECTIVE: To examine the common and specific characteristics of fibromyalgia and 
      lipedema, two chronic soft-tissue pain syndromes without curative therapy 
      options. METHODS: Diseases' characteristics were compared using the findings of 
      extensive literature and the empiric data from two cohorts, both fulfilling 
      standardized diagnostic criteria. Outcome was measured by various 
      socio-demographics, the generic Short Form 36 (SF-36), the Fibromyalgia Severity 
      Questionnaire (FSQ), and the 6-minute walk distance (6MWD). Empiric SF-36 data 
      were compared to specific population-based norms and between the diagnostic 
      groups, using standardized mean differences (SMD). RESULTS: Female participants 
      with fibromyalgia (n = 77) and lipedema (n = 112) showed comparable education 
      levels and living situations. Lipedema cases were, on average, 3.9 years younger 
      and BMI 6.3kg/m(2) more obese. Women with fibromyalgia smoked more, did less 
      sport, had more comorbidities, and worked less. Compared to the norms, health in 
      fibromyalgia was worse than expected by SMD = -1.60 to -2.35 and in lipedema by 
      -0.44 to -0.82 on the SF-36. The score differences between the two conditions 
      ranged from SMD = -0.96 to -1.34 (all p < 0.001) on the SF-36 and the FSQ. For 
      the inpatients (n = 77 fibromyalgia, n = 38 lipedema), the 6MWD was comparable 
      (SMD = -0.09, p = 0.640). These findings were consistent with detailed data from 
      the literature reviewed. DISCUSSION: Fibromyalgia and lipedema share 
      characteristics of clinical phenomenology and comorbid conditions. Disease 
      perception is more pronounced in fibromyalgia than in lipedema, especially in 
      social and role dysfunction, whereas the walking distance was similar for both 
      syndromes. This difference may be explicable by limited coping skills in 
      fibromyalgia.
CI  - (c) 2021 Angst et al.
FAU - Angst, Felix
AU  - Angst F
AD  - Research Department, Rehaklinik Bad Zurzach, Bad Zurzach, Switzerland.
FAU - Benz, Thomas
AU  - Benz T
AUID- ORCID: 0000-0001-6538-0022
AD  - Research Department, Rehaklinik Bad Zurzach, Bad Zurzach, Switzerland.
AD  - ZHAW Zurich University of Applied Sciences, School of Health Professions, 
      Institute of Physiotherapy, Winterthur, Switzerland.
FAU - Lehmann, Susanne
AU  - Lehmann S
AD  - Research Department, Rehaklinik Bad Zurzach, Bad Zurzach, Switzerland.
FAU - Sandor, Peter
AU  - Sandor P
AD  - Research Department, Rehaklinik Bad Zurzach, Bad Zurzach, Switzerland.
FAU - Wagner, Stephan
AU  - Wagner S
AD  - Department of Angiology, Rehaklinik Bad Zurzach, Bad Zurzach, Switzerland.
LA  - eng
PT  - Journal Article
DEP - 20210917
PL  - New Zealand
TA  - J Pain Res
JT  - Journal of pain research
JID - 101540514
PMC - PMC8455517
OTO - NOTNLM
OT  - SF-36
OT  - diagnosis
OT  - fibromyalgia
OT  - lipedema
OT  - outcome measures
COIS- Dr Stephan Wagner reports personal fees from Essity Switzerland, personal fees 
      from Sigvaris Switzerland, personal fees from Berro Switzerland/Juzo Germany, 
      outside the submitted work. There are no conflicts of interests or competing 
      interests to declare.
EDAT- 2021/09/25 06:00
MHDA- 2021/09/25 06:01
PMCR- 2021/09/17
CRDT- 2021/09/24 07:04
PHST- 2021/04/14 00:00 [received]
PHST- 2021/08/04 00:00 [accepted]
PHST- 2021/09/24 07:04 [entrez]
PHST- 2021/09/25 06:00 [pubmed]
PHST- 2021/09/25 06:01 [medline]
PHST- 2021/09/17 00:00 [pmc-release]
AID - 315736 [pii]
AID - 10.2147/JPR.S315736 [doi]
PST - epublish
SO  - J Pain Res. 2021 Sep 17;14:2931-2941. doi: 10.2147/JPR.S315736. eCollection 2021.