PMID- 34557399
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220426
IS  - 2234-8646 (Print)
IS  - 2234-8840 (Electronic)
IS  - 2234-8840 (Linking)
VI  - 24
IP  - 5
DP  - 2021 Sep
TI  - Relationship between Quantitative Sonographic Measurements and Serum Biochemical 
      Parameters in Childhood Obesity.
PG  - 470-482
LID - 10.5223/pghn.2021.24.5.470 [doi]
AB  - PURPOSE: We investigated the relationship between sonographic measurements of 
      fatty liver and body mass index standard deviation score (BMI-Z score), abdominal 
      wall fat thickness (AWFT), and serum biochemical parameters in childhood obesity. 
      METHODS: Anthropometric, laboratory, and ultrasonography data were obtained from 
      174 children with BMI-Z score >1. After the qualitative grading of 
      hepatosteatosis (grades 0-3), the quantitative liver-kidney echogenicity ratio 
      (LKER) was calculated using a software tool. Groups according to sex, age (AG-I 
      to AG-III), BMI-Z score (BMG-I to BMG-III), and hepatosteatosis degree (HS-I and 
      HS-II) were formed. The differences and distributions of the variables were 
      statistically analyzed and compared among the groups. RESULTS: Serum transaminase 
      and glucose levels showed a positive correlation with LKER, whereas the HDL level 
      showed a negative correlation. BMI-Z score and AWFT showed a positive correlation 
      with fasting insulin level and HOMA-IR value. LKER was significantly higher in 
      girls than in boys (p=0.008). In the AG-I group (age 3-8.9 years), the BMI-Z 
      score was significantly higher, whereas AWFT was significantly lower than in the 
      other age groups (p<0.001). The cutoff point of LKER for predicting grade 2 or 
      higher steatosis (HS-II group) was determined to be 1.83. Cardiovascular disease 
      risk was significantly higher in the HS-II group (p=0.035). CONCLUSION: As a 
      valuable quantitative measurement tool, LKER can be used for the sonographic 
      screening of fatty liver. AWFT, on the basis of its correlation with fasting 
      insulin level and HOMA-IR value, may be a useful sonographic parameter in the 
      management of childhood obesity.
CI  - Copyright (c) 2021 by The Korean Society of Pediatric Gastroenterology, Hepatology 
      and Nutrition.
FAU - Damar, Cagri
AU  - Damar C
AUID- ORCID: 0000-0001-7208-1290
AD  - Department of Pediatric Radiology, Faculty of Medicine, Gaziantep University, 
      Gaziantep, Turkey.
FAU - Isik, Emregul
AU  - Isik E
AUID- ORCID: 0000-0003-0162-6745
AD  - Clinics of Pediatric Endocrinology, Department of Pediatrics, Gaziantep 
      Children's Hospital, Gaziantep, Turkey.
FAU - Gungor, Sukru
AU  - Gungor S
AUID- ORCID: 0000-0002-0433-5970
AD  - Clinics of Pediatric Gastroenterology, Hepatology and Nutrition, Department of 
      Pediatrics, Faculty of Medicine, Kahramanmaras Sutcu Imam University, 
      Kahramanmaras, Turkey.
LA  - eng
PT  - Journal Article
DEP - 20210908
PL  - Korea (South)
TA  - Pediatr Gastroenterol Hepatol Nutr
JT  - Pediatric gastroenterology, hepatology & nutrition
JID - 101590471
PMC - PMC8443855
OTO - NOTNLM
OT  - Anthropometry
OT  - Childhood obesity
OT  - Hepatic steatosis
OT  - Pediatrics
OT  - Ultrasonography
COIS- Conflict of Interest: The authors have no financial conflicts of interest.
EDAT- 2021/09/25 06:00
MHDA- 2021/09/25 06:01
PMCR- 2021/09/01
CRDT- 2021/09/24 07:09
PHST- 2020/11/23 00:00 [received]
PHST- 2021/03/12 00:00 [revised]
PHST- 2021/07/10 00:00 [accepted]
PHST- 2021/09/24 07:09 [entrez]
PHST- 2021/09/25 06:00 [pubmed]
PHST- 2021/09/25 06:01 [medline]
PHST- 2021/09/01 00:00 [pmc-release]
AID - 10.5223/pghn.2021.24.5.470 [doi]
PST - ppublish
SO  - Pediatr Gastroenterol Hepatol Nutr. 2021 Sep;24(5):470-482. doi: 
      10.5223/pghn.2021.24.5.470. Epub 2021 Sep 8.