PMID- 34557401
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220426
IS  - 2234-8646 (Print)
IS  - 2234-8840 (Electronic)
IS  - 2234-8840 (Linking)
VI  - 24
IP  - 5
DP  - 2021 Sep
TI  - Immunogloboulin E-Mediated Food Sensitization in Children with Celiac Disease: A 
      Single-Center Experience.
PG  - 492-499
LID - 10.5223/pghn.2021.24.5.492 [doi]
AB  - PURPOSE: Celiac disease (CD) is an autoimmune disorder of the small intestine 
      caused by an abnormal immune response to gluten proteins and is often 
      characterized by gastrointestinal symptoms. Food allergy (FA) is an adverse 
      immune sensitivity to ingested food proteins leading to inflammation in various 
      organs including the gastrointestinal tract. The relationship between CD and FA 
      remains unclear. This study aimed to assess the prevalence and clinical relevance 
      of immunoglobulin E (IgE)-mediated food sensitization in children with CD. 
      METHODS: Fifty-nine children diagnosed with CD were reviewed for clinical 
      symptoms and evidence of IgE-sensitization to food and airborne allergens using 
      the PolyCheck method. RESULTS: IgE-mediated sensitization has been diagnosed in 
      20.3% of children with CD (CD/ A). In the CD/A group, 58.3% of children were 
      sensitized to food and 66.7% to airborne allergens. Further, 41.7% of patients 
      with CD and allergy reported gastrointestinal tract symptoms associated with the 
      ingestion of sensitizing foods. Analysis of the clinical status revealed that the 
      incidence of other allergic disorders in the CD/A group was as follows: atopic 
      dermatitis (33.3%), asthma (25.0%), and allergic rhinitis (16.7%). The percentage 
      of eosinophils was significantly higher in the CD/A group than in the CD group 
      (0.33+/-0.25 vs. 0.11+/-0.09; p=0.006). CONCLUSION: The diagnosis of CD does not 
      exclude FA. The gastrointestinal symptoms in children with CD may be the result 
      of both CD and FA; therefore, children with CD should be evaluated for the 
      presence of FA regardless of age.
CI  - Copyright (c) 2021 by The Korean Society of Pediatric Gastroenterology, Hepatology 
      and Nutrition.
FAU - Cudowska, Beata
AU  - Cudowska B
AUID- ORCID: 0000-0002-8062-5865
AD  - Department of Pediatrics, Gastroenterology, Hepatology, Nutrition and 
      Allergology, Medical University of Bialystok, Bialystok, Poland.
FAU - Lebensztejn, Dariusz M
AU  - Lebensztejn DM
AUID- ORCID: 0000-0003-0062-5257
AD  - Department of Pediatrics, Gastroenterology, Hepatology, Nutrition and 
      Allergology, Medical University of Bialystok, Bialystok, Poland.
LA  - eng
PT  - Journal Article
DEP - 20210908
PL  - Korea (South)
TA  - Pediatr Gastroenterol Hepatol Nutr
JT  - Pediatric gastroenterology, hepatology & nutrition
JID - 101590471
PMC - PMC8443858
OTO - NOTNLM
OT  - Celiac disease
OT  - Child
OT  - Food hypersensitivity
COIS- Conflict of Interest: The authors have no financial conflicts of interest.
EDAT- 2021/09/25 06:00
MHDA- 2021/09/25 06:01
PMCR- 2021/09/01
CRDT- 2021/09/24 07:09
PHST- 2021/04/09 00:00 [received]
PHST- 2021/07/26 00:00 [revised]
PHST- 2021/07/29 00:00 [accepted]
PHST- 2021/09/24 07:09 [entrez]
PHST- 2021/09/25 06:00 [pubmed]
PHST- 2021/09/25 06:01 [medline]
PHST- 2021/09/01 00:00 [pmc-release]
AID - 10.5223/pghn.2021.24.5.492 [doi]
PST - ppublish
SO  - Pediatr Gastroenterol Hepatol Nutr. 2021 Sep;24(5):492-499. doi: 
      10.5223/pghn.2021.24.5.492. Epub 2021 Sep 8.