PMID- 34557454
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220426
IS  - 2253-2447 (Print)
IS  - 2253-2447 (Electronic)
IS  - 2253-2447 (Linking)
VI  - 13
DP  - 2021
TI  - A Randomized, Single-Blinded Clinical Trial Evaluating the Effect of 
      Extracorporeal Shockwave Treatment (ESWT) as Add-On Therapy to Vacuum Erectile 
      Device on Peyronie's Disease.
PG  - 715-722
LID - 10.2147/RRU.S325929 [doi]
AB  - PURPOSE: The aim of this study was to investigate whether ESWT with a higher 
      energy as an add-on therapy to vacuum-pump followed by manipulation exercises 
      could reduce the penile curvature, pain and improve IIEF-5 score. MATERIALS AND 
      METHODS: Men aged >18 and <80 years and diagnosed with PD in stable phase with no 
      history of penile surgery or previous ESWT treatment were eligible to 
      participate. They were randomised to either active ESWT (n = 16) or sham ESWT (n 
      = 16). Both groups were treated once a week for five weeks. Each treatment 
      session consisted of 2000 shockwaves at 0.5mJ/mm(2). All patients in both groups 
      used a vacuum pump followed by manipulation exercises. RESULTS: Thirty men 
      completed the study protocol. Mean age in the treatment group was 61.7 (SD 8.3) 
      and 63 (SD 7.35) in the control group. After six months, mean change in penile 
      curvature was -12.8 (SD 13) degrees in the treatment group and -6.6 (SD 8.9) in 
      the control group (p = 0.204). Mean IIEF-5 score decreased by 0.17 (SD 3) in the 
      treatment group and 3.06 (SD 5.5) in the control group (p = 0.086) at six-month 
      follow-up. Pain was assessed using both VAS and PDQ and demonstrated no 
      difference between the groups after six months (p = 0.648). CONCLUSION: In the 
      treatment group, we observed a greater but non-significant change in penile 
      curvature and no adverse effects.
CI  - (c) 2021 Mortensen et al.
FAU - Mortensen, Jonas
AU  - Mortensen J
AD  - Department of Urology, Odense University Hospital, Odense, Denmark.
FAU - Skov-Jeppesen, Sune Moller
AU  - Skov-Jeppesen SM
AD  - Department of Urology, Odense University Hospital, Odense, Denmark.
AD  - Institute of Clinical Research, University of Southern Denmark, Odense, Denmark.
FAU - Ladegaard, Peter Bill Juul
AU  - Ladegaard PBJ
AD  - Department of Urology, Odense University Hospital, Odense, Denmark.
FAU - Lund, Lars
AU  - Lund L
AD  - Department of Urology, Odense University Hospital, Odense, Denmark.
AD  - Institute of Clinical Research, University of Southern Denmark, Odense, Denmark.
LA  - eng
PT  - Case Reports
PT  - Clinical Trial
DEP - 20210916
PL  - England
TA  - Res Rep Urol
JT  - Research and reports in urology
JID - 101576971
PMC - PMC8453443
OTO - NOTNLM
OT  - ESWT
OT  - Peyronie's disease
OT  - erectile dysfunction
OT  - manipulation exercises
OT  - vacuum pump
COIS- The authors report no conflicts of interest in this work.
EDAT- 2021/09/25 06:00
MHDA- 2021/09/25 06:01
PMCR- 2021/09/16
CRDT- 2021/09/24 07:10
PHST- 2021/06/25 00:00 [received]
PHST- 2021/08/16 00:00 [accepted]
PHST- 2021/09/24 07:10 [entrez]
PHST- 2021/09/25 06:00 [pubmed]
PHST- 2021/09/25 06:01 [medline]
PHST- 2021/09/16 00:00 [pmc-release]
AID - 325929 [pii]
AID - 10.2147/RRU.S325929 [doi]
PST - epublish
SO  - Res Rep Urol. 2021 Sep 16;13:715-722. doi: 10.2147/RRU.S325929. eCollection 2021.