PMID- 34558866
OWN - NLM
STAT- MEDLINE
DCOM- 20210927
LR  - 20220531
IS  - 1976-2437 (Electronic)
IS  - 0513-5796 (Print)
IS  - 0513-5796 (Linking)
VI  - 62
IP  - 10
DP  - 2021 Oct
TI  - Clinical Implication of Hypoxic Liver Injury for Predicting Hypoxic Hepatitis and 
      In-Hospital Mortality in ST Elevation Myocardial Infarction Patients.
PG  - 877-884
LID - 10.3349/ymj.2021.62.10.877 [doi]
AB  - PURPOSE: In this study, we aimed to determine the value of hypoxic liver injury 
      (HLI) in the emergency room (ER) for predicting hypoxic hepatitis (HH) and 
      in-hospital mortality in ST elevation myocardial infarction (STEMI) patients. 
      MATERIALS AND METHODS: 1537 consecutive STEMI patients were enrolled. HLI in the 
      ER was defined as a >/=2-fold increase in serum aspartate transaminase (AST). HH 
      was defined as a >/=20-fold increase in peak serum transaminase. Patients were 
      divided into four groups according to HLI and HH status (group 1, no HLI or HH; 
      group 2, HLI, but no HH; group 3, no HLI, but HH; group 4, both HLI and HH). 
      RESULTS: The incidences of HLI and HH in the ER were 22% and 2%, respectively. 
      In-hospital mortality rates were 3.1%, 11.8%, 28.6%, and 47.1% for groups 1, 2, 
      3, and 4, respectively. Patients with HLI and/or HH had worse Killip class, 
      higher cardiac biomarker elevations, and lower left ventricular ejection 
      fraction. Multivariate logistic regression analysis showed that HLI in the ER was 
      an independent predictor of HH [odds ratio 2.572, 95% confidence interval (CI) 
      1.166-5.675, p=0.019]. The predictive value of HLI in the ER for the development 
      of HH during hospitalization was favorable [area under the curve (AUC) 0.737, 95% 
      CI 0.643-0.830, sensitivity 0.548, specificity 0.805, for cut-off value AST >80]. 
      Furthermore, in terms of in-hospital mortality, predictive values of HLI in the 
      ER and HH during hospitalization were comparable (AUC 0.701 for HLI at ER and AUC 
      0.674 for HH). CONCLUSION: Among STEMI patients, HLI in the ER is a significant 
      predictor for the development of HH and mortality during hospitalization 
      (INTERSTELLAR ClinicalTrials.gov number, NCT02800421).
CI  - (c) Copyright: Yonsei University College of Medicine 2021.
FAU - Choi, Seong Huan
AU  - Choi SH
AUID- ORCID: 0000-0001-8253-9242
AD  - Department of Cardiology, Inha University Hospital, Incheon, Korea.
FAU - Jang, Ho-Jun
AU  - Jang HJ
AUID- ORCID: 0000-0001-9891-2603
AD  - Department of Cardiology, Sejong General Hospital, Bucheon, Korea.
FAU - Suh, Young Ju
AU  - Suh YJ
AUID- ORCID: 0000-0002-6816-8067
AD  - Department of Biomedical Sciences, College of Medicine, Inha University, Incheon, 
      Korea.
FAU - Park, Sang-Don
AU  - Park SD
AUID- ORCID: 0000-0003-0128-9988
AD  - Department of Cardiology, Inha University Hospital, Incheon, Korea.
FAU - Oh, Pyung Chun
AU  - Oh PC
AUID- ORCID: 0000-0002-9955-223X
AD  - Department of Cardiology, Gil Medical Center, Gachon University, Incheon, Korea.
FAU - Moon, Jeonggeun
AU  - Moon J
AUID- ORCID: 0000-0001-6431-2802
AD  - Department of Cardiology, Gil Medical Center, Gachon University, Incheon, Korea.
FAU - Lee, Kyounghoon
AU  - Lee K
AUID- ORCID: 0000-0001-8313-9806
AD  - Department of Cardiology, Gil Medical Center, Gachon University, Incheon, Korea.
FAU - Suh, Jon
AU  - Suh J
AUID- ORCID: 0000-0001-9593-8453
AD  - Department of Cardiology, Soon Chun Hyang University Bucheon Hospital, Bucheon, 
      Korea.
FAU - Kang, WoongChol
AU  - Kang W
AUID- ORCID: 0000-0003-4590-7178
AD  - Department of Cardiology, Gil Medical Center, Gachon University, Incheon, Korea.
FAU - Kim, Tae-Hoon
AU  - Kim TH
AUID- ORCID: 0000-0002-4032-1285
AD  - Division of Cardiology, CHA Medical Center, Ilsan Hospital, Goyang, Korea. 
      sch.kimtaehoon@gmail.com.
FAU - Kwon, Sung Woo
AU  - Kwon SW
AUID- ORCID: 0000-0002-0679-1523
AD  - Department of Cardiology, Inha University Hospital, Incheon, Korea. 
      kwonswdr@gmail.com.
LA  - eng
SI  - ClinicalTrials.gov/NCT02800421
GR  - Inha University Hospital/Korea
PT  - Journal Article
PT  - Observational Study
PL  - Korea (South)
TA  - Yonsei Med J
JT  - Yonsei medical journal
JID - 0414003
SB  - IM
MH  - *Hepatitis
MH  - Hospital Mortality
MH  - Humans
MH  - *Percutaneous Coronary Intervention
MH  - Prognosis
MH  - *ST Elevation Myocardial Infarction
MH  - Stroke Volume
MH  - Ventricular Function, Left
PMC - PMC8470566
OTO - NOTNLM
OT  - STEMI
OT  - hypoxic hepatitis
OT  - hypoxic liver injury
OT  - in-hospital mortality
COIS- The authors have no potential conflicts of interest to disclose.
EDAT- 2021/09/25 06:00
MHDA- 2021/09/28 06:00
PMCR- 2021/10/01
CRDT- 2021/09/24 09:01
PHST- 2020/11/19 00:00 [received]
PHST- 2021/06/11 00:00 [revised]
PHST- 2021/07/13 00:00 [accepted]
PHST- 2021/09/24 09:01 [entrez]
PHST- 2021/09/25 06:00 [pubmed]
PHST- 2021/09/28 06:00 [medline]
PHST- 2021/10/01 00:00 [pmc-release]
AID - 62.877 [pii]
AID - 10.3349/ymj.2021.62.10.877 [doi]
PST - ppublish
SO  - Yonsei Med J. 2021 Oct;62(10):877-884. doi: 10.3349/ymj.2021.62.10.877.