PMID- 34559319
OWN - NLM
STAT- MEDLINE
DCOM- 20220228
LR  - 20220228
IS  - 1435-1463 (Electronic)
IS  - 0300-9564 (Linking)
VI  - 128
IP  - 12
DP  - 2021 Dec
TI  - Association between heart rate variability and striatal dopamine depletion in 
      Parkinson's disease.
PG  - 1835-1840
LID - 10.1007/s00702-021-02418-9 [doi]
AB  - Striatal dopamine depletion is associated with not only motor symptom but also 
      non-motor symptoms in patients with Parkinson's disease (PD). The purpose is to 
      elucidate the relation between heart rate variability (HRV) and dopaminergic 
      depletion in specific striatal subregions. The subjects were 84 patients with 
      newly diagnosed untreated PD. All patients underwent striatal 
      (123)I-2beta-carbomethoxy-3beta-(4-iodophenyl)-N-(3-fluoropropyl) nortropane 
      ((123)I-FP-CIT) dopamine transporter single-photon emission computed tomography 
      (DAT-SPECT). DaTQUANT software (GE Healthcare) was used as a semi-quantitative 
      tool to analyze DAT-SPECT data. Association of HRV with dopaminergic depletion in 
      specific striatal subregions was examined. HRV was related to dopamine depletion 
      in the caudate and anterior putamen, especially the left side, after controlling 
      for age, hemoglobin A1c level, disease duration, motor severity and global 
      cognition on multiple regression analysis (left caudate p = 0.012). HRV was 
      closely related to striatal dopamine depletion, especially in the left 
      associative striatum, in patients with PD.
CI  - (c) 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Austria, 
      part of Springer Nature.
FAU - Kitagawa, Tomomichi
AU  - Kitagawa T
AD  - Departments of Neurology, The Jikei University School of Medicine, 3-25-8 
      Nishi-shimbashi, Minato-ku, Tokyo, 105-8461, Japan.
FAU - Umehara, Tadashi
AU  - Umehara T
AUID- ORCID: 0000-0003-4156-5617
AD  - Departments of Neurology, The Jikei University School of Medicine, 3-25-8 
      Nishi-shimbashi, Minato-ku, Tokyo, 105-8461, Japan. tumety@jikei.ac.jp.
FAU - Oka, Hisayoshi
AU  - Oka H
AD  - Department of Neurology, Daisan Hospital, The Jikei University School of 
      Medicine, 4-11-1 Izumihoncho, Komae-shi, Tokyo, 201-8601, Japan.
FAU - Shiraishi, Tomotaka
AU  - Shiraishi T
AD  - Departments of Neurology, The Jikei University School of Medicine, 3-25-8 
      Nishi-shimbashi, Minato-ku, Tokyo, 105-8461, Japan.
FAU - Sato, Takeo
AU  - Sato T
AD  - Departments of Neurology, The Jikei University School of Medicine, 3-25-8 
      Nishi-shimbashi, Minato-ku, Tokyo, 105-8461, Japan.
FAU - Takatsu, Hiroki
AU  - Takatsu H
AD  - Departments of Neurology, The Jikei University School of Medicine, 3-25-8 
      Nishi-shimbashi, Minato-ku, Tokyo, 105-8461, Japan.
FAU - Nakahara, Atsuo
AU  - Nakahara A
AD  - Department of Neurology, Daisan Hospital, The Jikei University School of 
      Medicine, 4-11-1 Izumihoncho, Komae-shi, Tokyo, 201-8601, Japan.
FAU - Matsuno, Hiromasa
AU  - Matsuno H
AD  - Departments of Neurology, The Jikei University School of Medicine, 3-25-8 
      Nishi-shimbashi, Minato-ku, Tokyo, 105-8461, Japan.
FAU - Bono, Keiko
AU  - Bono K
AD  - Departments of Neurology, The Jikei University School of Medicine, 3-25-8 
      Nishi-shimbashi, Minato-ku, Tokyo, 105-8461, Japan.
FAU - Omoto, Shusaku
AU  - Omoto S
AD  - Departments of Neurology, The Jikei University School of Medicine, 3-25-8 
      Nishi-shimbashi, Minato-ku, Tokyo, 105-8461, Japan.
FAU - Murakami, Hidetomo
AU  - Murakami H
AD  - Departments of Neurology, The Jikei University School of Medicine, 3-25-8 
      Nishi-shimbashi, Minato-ku, Tokyo, 105-8461, Japan.
FAU - Sengoku, Renpei
AU  - Sengoku R
AD  - Department of Neurology, Daisan Hospital, The Jikei University School of 
      Medicine, 4-11-1 Izumihoncho, Komae-shi, Tokyo, 201-8601, Japan.
FAU - Iguchi, Yasuyuki
AU  - Iguchi Y
AD  - Departments of Neurology, The Jikei University School of Medicine, 3-25-8 
      Nishi-shimbashi, Minato-ku, Tokyo, 105-8461, Japan.
LA  - eng
PT  - Journal Article
DEP - 20210924
PL  - Austria
TA  - J Neural Transm (Vienna)
JT  - Journal of neural transmission (Vienna, Austria : 1996)
JID - 9702341
RN  - 0 (Dopamine Plasma Membrane Transport Proteins)
RN  - 0 (Tropanes)
RN  - VTD58H1Z2X (Dopamine)
SB  - IM
EIN - J Neural Transm (Vienna). 2021 Oct 19;:. PMID: 34665310
MH  - Corpus Striatum/diagnostic imaging/metabolism
MH  - *Dopamine
MH  - Dopamine Plasma Membrane Transport Proteins/metabolism
MH  - Heart Rate
MH  - Humans
MH  - *Parkinson Disease/complications/diagnostic imaging
MH  - Tomography, Emission-Computed, Single-Photon/methods
MH  - Tropanes
OTO - NOTNLM
OT  - Associative striatum
OT  - DaTQUANT
OT  - Heart rate variability
OT  - Parkinson's disease
EDAT- 2021/09/25 06:00
MHDA- 2022/03/01 06:00
CRDT- 2021/09/24 12:24
PHST- 2021/07/19 00:00 [received]
PHST- 2021/09/10 00:00 [accepted]
PHST- 2021/09/25 06:00 [pubmed]
PHST- 2022/03/01 06:00 [medline]
PHST- 2021/09/24 12:24 [entrez]
AID - 10.1007/s00702-021-02418-9 [pii]
AID - 10.1007/s00702-021-02418-9 [doi]
PST - ppublish
SO  - J Neural Transm (Vienna). 2021 Dec;128(12):1835-1840. doi: 
      10.1007/s00702-021-02418-9. Epub 2021 Sep 24.