PMID- 34560231
OWN - NLM
STAT- MEDLINE
DCOM- 20220318
LR  - 20220318
IS  - 1873-5894 (Electronic)
IS  - 0730-725X (Linking)
VI  - 84
DP  - 2021 Dec
TI  - Preliminary quantitative analysis of vertebral microenvironment changes in type 2 
      diabetes mellitus using FOCUS IVIM-DWI and IDEAL-IQ sequences.
PG  - 84-91
LID - S0730-725X(21)00162-4 [pii]
LID - 10.1016/j.mri.2021.09.008 [doi]
AB  - PURPOSE: To explore the application of intravoxel incoherent motion 
      diffusion-weighted imaging(IVIM-DWI) on account of field-of-view optimized and 
      constrained undistorted single shot (FOCUS) and iteraterative decomposition of 
      water and fat with echo asymmetry and least-squares estimation 
      quantitation(IDEAL-IQ) sequences in evaluating the vertebral microenvironment 
      changes of type 2 diabetes mellitus(T2DM) patients and the correlation with bone 
      mineral density(BMD). METHOD: 128 T2DM patients (mean age 63.4 +/- 5.28 years) 
      underwent both dual-energy X-ray absorptiometry (DEXA) and spine MRI. The FOCUS 
      IVIM-DWI and IDEAL-IQ derived parameters of the vertebral body(L1, L2, L3, 
      L4)were measured on corresponding maps of the lumbar spine. The subjects were 
      divided into 3 groups according to T-scores as follows: normal (n = 37), 
      osteopenia (n = 43), and osteoporosis(n = 48) group.One-way analysis of variance 
      (ANOVA) were used to compare the vertebral parameters(ADC(slow), ADC(fast), f, 
      FF, R2*) among three BMD cohorts.Receiver operating characteristic (ROC) analyses 
      and Spearman's rank correlation were performed to test the diagnostic performance 
      and the correlation between them respectively. RESULTS: There were significant 
      differences in vertebral ADC(slow), ADC(fast), FF and R2* between the three 
      groups (P < 0.05).Statistically, BMD was moderately negatively correlated with FF 
      (r = -0.584, P < 0.001) and weakly positively with ADC(slow) (r = 0.334, 
      P < 0.001), meanwhile moderately positively correlated with R2*(r = 0.509, 
      P < 0.001) and ADC(fast)(0.545, P < 0.001).ADC(fast) was moderately negatively 
      correlated with FF (r = -0.417, P < 0.001), weakly positively correlated with 
      R2*(0.359, P < 0.001).Compared with the area under the curve (AUC) of ADC(slow), 
      ADC(fast), FF and R2*, the AUC of ADC(fast) was higher in identifying between 
      normal and abnormal(osteopenia and osteoporosis), normal from osteopenia, while 
      the AUC of FF was higher in identifying osteopenia from osteoporosis. 
      CONCLUSIONS: FOCUS IVIM-DWI and IDEAL-IQ of lumbar spine might be useful to 
      evaluate the vertebral microenvironment changes of T2DM patients.
CI  - Copyright (c) 2021 The Authors. Published by Elsevier Inc. All rights reserved.
FAU - Yang, Hui
AU  - Yang H
AD  - Department of Radiology, The Second Affiliated Hospital of Shandong First Medical 
      University, Tai'an 271000, Shandong, China.
FAU - Cui, Xiaojie
AU  - Cui X
AD  - Department of Radiology, The Second Affiliated Hospital of Shandong First Medical 
      University, Tai'an 271000, Shandong, China.
FAU - Zheng, Xiuzhu
AU  - Zheng X
AD  - Department of Radiology, The Second Affiliated Hospital of Shandong First Medical 
      University, Tai'an 271000, Shandong, China.
FAU - Li, Jiang
AU  - Li J
AD  - Department of Radiology, The Second Affiliated Hospital of Shandong First Medical 
      University, Tai'an 271000, Shandong, China.
FAU - Yao, Qianqian
AU  - Yao Q
AD  - Department of Radiology, The Second Affiliated Hospital of Shandong First Medical 
      University, Tai'an 271000, Shandong, China.
FAU - Li, Xiaoqian
AU  - Li X
AD  - Department of Radiology, The Second Affiliated Hospital of Shandong First Medical 
      University, Tai'an 271000, Shandong, China.
FAU - Qin, Jian
AU  - Qin J
AD  - Department of Radiology, The Second Affiliated Hospital of Shandong First Medical 
      University, Tai'an 271000, Shandong, China. Electronic address: 
      sdqinjian@126.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210921
PL  - Netherlands
TA  - Magn Reson Imaging
JT  - Magnetic resonance imaging
JID - 8214883
SB  - IM
MH  - Aged
MH  - *Diabetes Mellitus, Type 2/diagnostic imaging
MH  - Diffusion Magnetic Resonance Imaging
MH  - Humans
MH  - Lumbar Vertebrae/diagnostic imaging
MH  - Magnetic Resonance Imaging
MH  - Middle Aged
MH  - *Osteoporosis/diagnostic imaging
OTO - NOTNLM
OT  - Intravoxel incoherent motion;diffusion magnetic resonance imaging;fat fraction
OT  - Lumbar spine
OT  - Osteoporosis
EDAT- 2021/09/25 06:00
MHDA- 2022/03/19 06:00
CRDT- 2021/09/24 20:15
PHST- 2021/07/10 00:00 [received]
PHST- 2021/09/10 00:00 [revised]
PHST- 2021/09/16 00:00 [accepted]
PHST- 2021/09/25 06:00 [pubmed]
PHST- 2022/03/19 06:00 [medline]
PHST- 2021/09/24 20:15 [entrez]
AID - S0730-725X(21)00162-4 [pii]
AID - 10.1016/j.mri.2021.09.008 [doi]
PST - ppublish
SO  - Magn Reson Imaging. 2021 Dec;84:84-91. doi: 10.1016/j.mri.2021.09.008. Epub 2021 
      Sep 21.