PMID- 34560415
OWN - NLM
STAT- MEDLINE
DCOM- 20211105
LR  - 20211105
IS  - 1872-9142 (Electronic)
IS  - 0161-5890 (Linking)
VI  - 139
DP  - 2021 Nov
TI  - Regulation of dendritic cell function by Fc-gamma-receptors and the neonatal Fc 
      receptor.
PG  - 193-201
LID - S0161-5890(21)00274-1 [pii]
LID - 10.1016/j.molimm.2021.07.024 [doi]
AB  - Dendritic cells (DCs) express receptors to sense pathogens and/or tissue damage 
      and to communicate with other immune cells. Among those receptors, Fc receptors 
      (FcRs) are triggered by the Fc region of antibodies produced during adaptive 
      immunity. In this review, the role of FcgammaR and neonatal Fc receptor (FcRn) in DC 
      immunity will be discussed. Their expression in DC subsets and impact on antigen 
      uptake and presentation, DC maturation and polarisation of T cell responses will 
      be described. Lastly, we will discuss the importance of FcR-mediated DC function 
      in the context of immunity during viral infection, inflammatory disease, cancer 
      and immunotherapy.
CI  - Copyright (c) 2021 Elsevier Ltd. All rights reserved.
FAU - Macri, Christophe
AU  - Macri C
AD  - Department of Biochemistry and Pharmacology, The University of Melbourne, Bio21 
      Molecular Science and Biotechnology Institute, 30 Flemington Rd, Parkville, 
      Victoria, 3010, Australia.
FAU - Morgan, Huw
AU  - Morgan H
AD  - ACRF Translational Research Laboratory, The Royal Melbourne Hospital, Parkville, 
      Melbourne, Victoria, 3050, Australia; Department of Medicine, University of 
      Melbourne, Parkville, Melbourne, Victoria, 3010, Australia.
FAU - Villadangos, Jose A
AU  - Villadangos JA
AD  - Department of Biochemistry and Pharmacology, The University of Melbourne, Bio21 
      Molecular Science and Biotechnology Institute, 30 Flemington Rd, Parkville, 
      Victoria, 3010, Australia; Department of Microbiology and Immunology, Peter 
      Doherty Institute for Infection and Immunity, The University of Melbourne, 
      Parkville, Victoria, 3010, Australia. Electronic address: 
      j.villadangos@unimelb.edu.au.
FAU - Mintern, Justine D
AU  - Mintern JD
AD  - Department of Biochemistry and Pharmacology, The University of Melbourne, Bio21 
      Molecular Science and Biotechnology Institute, 30 Flemington Rd, Parkville, 
      Victoria, 3010, Australia. Electronic address: jmintern@unimelb.edu.au.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20210923
PL  - England
TA  - Mol Immunol
JT  - Molecular immunology
JID - 7905289
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (Receptors, Fc)
RN  - 0 (Receptors, IgG)
RN  - TW3XAW0RCY (Fc receptor, neonatal)
SB  - IM
MH  - Animals
MH  - Antigen Presentation/*immunology
MH  - Dendritic Cells/*immunology
MH  - Histocompatibility Antigens Class I/*immunology
MH  - Humans
MH  - Lymphocyte Activation/immunology
MH  - Receptors, Fc/*immunology
MH  - Receptors, IgG/*immunology
OTO - NOTNLM
OT  - Dendritic cells
OT  - Fc receptors
OT  - FcRn
OT  - FcgammaR
OT  - Immune complexes
EDAT- 2021/09/25 06:00
MHDA- 2021/11/06 06:00
CRDT- 2021/09/24 20:24
PHST- 2020/09/11 00:00 [received]
PHST- 2021/06/28 00:00 [revised]
PHST- 2021/07/19 00:00 [accepted]
PHST- 2021/09/25 06:00 [pubmed]
PHST- 2021/11/06 06:00 [medline]
PHST- 2021/09/24 20:24 [entrez]
AID - S0161-5890(21)00274-1 [pii]
AID - 10.1016/j.molimm.2021.07.024 [doi]
PST - ppublish
SO  - Mol Immunol. 2021 Nov;139:193-201. doi: 10.1016/j.molimm.2021.07.024. Epub 2021 
      Sep 23.