PMID- 34561238
OWN - NLM
STAT- MEDLINE
DCOM- 20211213
LR  - 20211214
IS  - 2373-2822 (Electronic)
IS  - 2373-2822 (Linking)
VI  - 8
IP  - 5
DP  - 2021 Sep-Oct
TI  - Test-Retest Reliability of Short-Interval Intracortical Inhibition Assessed by 
      Threshold-Tracking and Automated Conventional Techniques.
LID - ENEURO.0103-21.2021 [pii]
LID - 10.1523/ENEURO.0103-21.2021 [doi]
AB  - Two novel short-interval intracortical inhibition (SICI) protocols, assessing 
      SICI across a range of interstimulus intervals (ISIs) using either parallel 
      threshold-tracking transcranial magnetic stimulation (TT-TMS) or automated 
      conventional TMS (cTMS), were recently introduced. However, the test-retest 
      reliability of these protocols has not been investigated, which is important if 
      they are to be introduced in the clinic. SICI was recorded in 18 healthy subjects 
      using TT-TMS (T-SICI) and cTMS (A-SICI). All subjects were examined at four 
      identical sessions, i.e., morning and afternoon sessions on 2 d, 5-7 d apart. 
      Both SICI protocols were performed twice at each session by the same observer. In 
      one of the sessions, another observer performed additional examinations. Neither 
      intraobserver nor interobserver measures of SICI differed significantly between 
      examinations, except for T-SICI at ISI 3 ms (p = 0.00035) and A-SICI at ISI 
      2.5 ms (p = 0.0103). Intraday reliability was poor-to-good for A-SICI and 
      moderate-to-good for T-SICI. Interday and interobserver reliabilities of T-SICI 
      and A-SICI were moderate-to-good. Although between-subject variation constituted 
      most of the total variation, SICI repeatability in an individual subject was 
      poor. The two SICI protocols showed no considerable systematic bias across 
      sessions and had a comparable test-retest reliability profile. Findings from the 
      present study suggest that both SICI protocols may be reliably and reproducibly 
      employed in research studies, but should be used with caution for individual 
      decision-making in clinical settings. Studies exploring reliability in patient 
      cohorts are warranted to investigate the clinical utility of these two SICI 
      protocols.
CI  - Copyright (c) 2021 Nielsen et al.
FAU - Nielsen, Christina S-Z
AU  - Nielsen CS
AUID- ORCID: 0000-0002-1844-6292
AD  - Department of Clinical Neurophysiology, Aarhus University Hospital, Aarhus 8200, 
      Denmark.
AD  - Department of Clinical Medicine, Faculty of Health, Aarhus University, Aarhus 
      8200, Denmark.
FAU - Samusyte, Gintaute
AU  - Samusyte G
AD  - Department of Neurology, Medical Academy, Lithuanian University of Health 
      Sciences, Kaunas 44307, Lithuania.
FAU - Pugdahl, Kirsten
AU  - Pugdahl K
AD  - Department of Clinical Neurophysiology, Aarhus University Hospital, Aarhus 8200, 
      Denmark.
AD  - Department of Clinical Medicine, Faculty of Health, Aarhus University, Aarhus 
      8200, Denmark.
FAU - Blicher, Jakob U
AU  - Blicher JU
AUID- ORCID: 0000-0003-3443-4790
AD  - Center of Functionally Integrative Neuroscience, Department of Clinical Medicine, 
      Aarhus University, Aarhus 8200, Denmark.
FAU - Fuglsang-Frederiksen, Anders
AU  - Fuglsang-Frederiksen A
AD  - Department of Clinical Neurophysiology, Aarhus University Hospital, Aarhus 8200, 
      Denmark.
AD  - Department of Clinical Medicine, Faculty of Health, Aarhus University, Aarhus 
      8200, Denmark.
FAU - Cengiz, Bulent
AU  - Cengiz B
AD  - Department of Neurology, Gazi University, Faculty of Medicine, Ankara 06500, 
      Turkey.
FAU - Tankisi, Hatice
AU  - Tankisi H
AD  - Department of Clinical Neurophysiology, Aarhus University Hospital, Aarhus 8200, 
      Denmark hatitank@rm.dk.
AD  - Department of Clinical Medicine, Faculty of Health, Aarhus University, Aarhus 
      8200, Denmark.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20211019
PL  - United States
TA  - eNeuro
JT  - eNeuro
JID - 101647362
SB  - IM
MH  - Electromyography
MH  - *Evoked Potentials, Motor
MH  - Humans
MH  - *Motor Cortex
MH  - Neural Inhibition
MH  - Reproducibility of Results
PMC - PMC8528507
OTO - NOTNLM
OT  - automated conventional TMS
OT  - short-interval intracortical inhibition
OT  - test-retest reliability
OT  - threshold-tracking TMS
OT  - transcranial magnetic stimulation
EDAT- 2021/09/26 06:00
MHDA- 2021/12/15 06:00
PMCR- 2021/10/19
CRDT- 2021/09/25 05:35
PHST- 2021/03/08 00:00 [received]
PHST- 2021/08/09 00:00 [revised]
PHST- 2021/08/20 00:00 [accepted]
PHST- 2021/09/26 06:00 [pubmed]
PHST- 2021/12/15 06:00 [medline]
PHST- 2021/09/25 05:35 [entrez]
PHST- 2021/10/19 00:00 [pmc-release]
AID - ENEURO.0103-21.2021 [pii]
AID - eN-MNT-0103-21 [pii]
AID - 10.1523/ENEURO.0103-21.2021 [doi]
PST - epublish
SO  - eNeuro. 2021 Oct 19;8(5):ENEURO.0103-21.2021. doi: 10.1523/ENEURO.0103-21.2021. 
      Print 2021 Sep-Oct.