PMID- 34561419
OWN - NLM
STAT- MEDLINE
DCOM- 20220204
LR  - 20220204
IS  - 2044-5385 (Electronic)
IS  - 2044-5385 (Linking)
VI  - 11
IP  - 9
DP  - 2021 Sep 24
TI  - Syngeneic hematopoietic stem cell transplantation for acute myeloid leukemia: a 
      propensity score-matched analysis.
PG  - 159
LID - 10.1038/s41408-021-00553-w [doi]
LID - 159
AB  - The present study evaluated outcomes and prognostic factors in adult patients 
      with acute myeloid leukemia (AML) after syngeneic hematopoietic stem cell 
      transplantation (HSCT). Among patients in first complete remission (CR1), 
      outcomes of syngeneic HSCT (Syn) were compared with those of autologous HSCT 
      (Auto), allogeneic HSCT from human leukocyte antigen (HLA)-matched sibling donor 
      (MSD), or allogeneic HSCT from HLA-matched unrelated donor (MUD). Among 11,866 
      patients receiving first HSCT, 26 in the Syn group were analyzed. The 5-year 
      overall survival (OS) rate, the cumulative incidence of relapse, and the 
      cumulative incidence of non-relapse mortality (NRM) were 47.8%, 59.6%, and 4.6%, 
      respectively. The OS was significantly better in patients in CR1 (n = 13) than in 
      patients in non-CR1 (P = 0.012). Furthermore, 39 patients in CR1 each were 
      assigned to the Auto, MSD, and MUD groups using propensity score matching. The 
      5-year OS in the Syn (68.4%) was not significantly different from those in the 
      Auto (55.9%, P = 0.265), MSD (62.4%, P = 0.419), or MUD (63.7%, P = 0.409) 
      groups. A higher relapse in the Syn than in the MSD and MUD groups was offset by 
      lower NRM. In summary, syngeneic HSCT might be an alternative option for AML 
      patients in CR1.
CI  - (c) 2021. The Author(s).
FAU - Kurosawa, Shuhei
AU  - Kurosawa S
AUID- ORCID: 0000-0001-6426-6770
AD  - Division of Stem Cell and Molecular Medicine, The Institute of Medical Science, 
      The University of Tokyo, Tokyo, Japan. shuhei-kurosawa@g.ecc.u-tokyo.ac.jp.
FAU - Mizuno, Shohei
AU  - Mizuno S
AUID- ORCID: 0000-0002-4405-8808
AD  - Division of Hematology, Department of Internal Medicine, Aichi Medical 
      University, Nagakute, Japan.
FAU - Arai, Yasuyuki
AU  - Arai Y
AUID- ORCID: 0000-0002-9662-5093
AD  - Department of Hematology, Kyoto University Hospital, Kyoto, Japan.
FAU - Masuko, Masayoshi
AU  - Masuko M
AD  - Division of Stem Cell Transplantation, Niigata University Medical and Dental 
      Hospital, Niigata, Japan.
FAU - Kanda, Junya
AU  - Kanda J
AUID- ORCID: 0000-0002-6704-3633
AD  - Department of Hematology and Oncology, Graduate School of Medicine, Kyoto 
      University, Kyoto, Japan.
FAU - Kohno, Kentaro
AU  - Kohno K
AD  - Department of Hematology and Oncology, Japan Community Health Care Organization 
      (JCHO) Kyushu Hospital, Kitakyushu, Japan.
FAU - Onai, Daishi
AU  - Onai D
AD  - Hematology Division, Tokyo Metropolitan Cancer and Infectious Diseases Center, 
      Komagome Hospital, Tokyo, Japan.
FAU - Fukuda, Takahiro
AU  - Fukuda T
AD  - Department of Hematopoietic Stem Cell Transplantation, National Cancer Center 
      Hospital, Tokyo, Japan.
FAU - Ozawa, Yukiyasu
AU  - Ozawa Y
AD  - Department of Hematology, Japanese Red Cross Nagoya First Hospital, Nagoya, 
      Japan.
FAU - Katayama, Yuta
AU  - Katayama Y
AUID- ORCID: 0000-0001-5054-9104
AD  - Department of Hematology, Hiroshima Red Cross Hospital & Atomic-bomb Survivors 
      Hospital, Hiroshima, Japan.
FAU - Tanaka, Masatsugu
AU  - Tanaka M
AD  - Department of Hematology, Kanagawa Cancer Center, Yokohama, Japan.
FAU - Ikegame, Kazuhiro
AU  - Ikegame K
AUID- ORCID: 0000-0002-5421-7470
AD  - Department of Hematology, Hyogo College of Medicine Hospital, Nishinomiya, Japan.
FAU - Uchida, Naoyuki
AU  - Uchida N
AUID- ORCID: 0000-0001-5952-5926
AD  - Department of Hematology, Federation of National Public Service Personnel Mutual 
      Aid Associations Toranomon Hospital, Tokyo, Japan.
FAU - Eto, Tetsuya
AU  - Eto T
AD  - Department of Hematology, Hamanomachi Hospital, Fukuoka, Japan.
FAU - Ota, Shuichi
AU  - Ota S
AUID- ORCID: 0000-0002-3631-244X
AD  - Department of Hematology, Sapporo Hokuyu Hospital, Sapporo, Japan.
FAU - Tanaka, Junji
AU  - Tanaka J
AD  - Department of Hematology, Tokyo Women's Medical University, Tokyo, Japan.
FAU - Ichinohe, Tatsuo
AU  - Ichinohe T
AUID- ORCID: 0000-0002-0393-4066
AD  - Department of Hematology and Oncology, Research Institute for Radiation Biology 
      and Medicine, Hiroshima University, Higashi-Hiroshima, Japan.
FAU - Atsuta, Yoshiko
AU  - Atsuta Y
AUID- ORCID: 0000-0003-4404-2870
AD  - Japanese Data Center for Hematopoietic Cell Transplantation, Nagoya, Japan.
AD  - Department of Healthcare Administration, Nagoya University Graduate School of 
      Medicine, Nagoya, Japan.
FAU - Yanada, Masamitsu
AU  - Yanada M
AUID- ORCID: 0000-0003-1602-9775
AD  - Department of Hematology and Cell Therapy, Aichi Cancer Center, Nagoya, Japan.
LA  - eng
PT  - Journal Article
DEP - 20210924
PL  - United States
TA  - Blood Cancer J
JT  - Blood cancer journal
JID - 101568469
SB  - IM
MH  - Adult
MH  - Female
MH  - *Hematopoietic Stem Cell Transplantation
MH  - Humans
MH  - Leukemia, Myeloid, Acute/epidemiology/*therapy
MH  - Male
MH  - Middle Aged
MH  - Propensity Score
MH  - Transplantation, Autologous
MH  - Transplantation, Isogeneic
MH  - Treatment Outcome
MH  - Young Adult
PMC - PMC8463668
COIS- The authors declare no competing interests.
EDAT- 2021/09/26 06:00
MHDA- 2022/02/05 06:00
PMCR- 2021/09/24
CRDT- 2021/09/25 05:39
PHST- 2021/08/05 00:00 [received]
PHST- 2021/09/09 00:00 [accepted]
PHST- 2021/09/07 00:00 [revised]
PHST- 2021/09/25 05:39 [entrez]
PHST- 2021/09/26 06:00 [pubmed]
PHST- 2022/02/05 06:00 [medline]
PHST- 2021/09/24 00:00 [pmc-release]
AID - 10.1038/s41408-021-00553-w [pii]
AID - 553 [pii]
AID - 10.1038/s41408-021-00553-w [doi]
PST - epublish
SO  - Blood Cancer J. 2021 Sep 24;11(9):159. doi: 10.1038/s41408-021-00553-w.