PMID- 34561496
OWN - NLM
STAT- MEDLINE
DCOM- 20220106
LR  - 20220106
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 11
IP  - 1
DP  - 2021 Sep 24
TI  - Galectin-3 for prediction of cardiac function compared to NT-proBNP in 
      individuals with prediabetes and type 2 diabetes mellitus.
PG  - 19012
LID - 10.1038/s41598-021-98227-x [doi]
LID - 19012
AB  - Use of galectin-3 for assessing cardiac function in prediabetes and type 2 
      diabetes mellitus (T2DM) needs to be established. Within the Gutenberg Health 
      Study cohort (N = 15,010, 35-74 years) patient characteristics were investigated 
      regarding galectin-3 levels. Prognostic value of galectin-3 compared to NT-proBNP 
      concerning cardiac function and mortality was assessed in individuals with 
      euglycaemia, prediabetes and T2DM in 5 years follow-up. Higher galectin-3 levels 
      related to older age, female sex and higher prevalence for prediabetes, T2DM, 
      cardiovascular risk factors and comorbidities. Galectin-3 cross-sectionally was 
      related to impaired systolic (beta - 0.36, 95% CI - 0.63/- 0.09; P = 0.008) and 
      diastolic function (beta 0.014, 95% CI 0.001/0.03; P = 0.031) in T2DM and reduced 
      systolic function in prediabetes (beta - 0.34, 95% CI - 0.53/- 0.15; P = 0.00045). 
      Galectin-3 prospectively related to systolic (beta - 0.656, 95% CI - 1.07/- 0.24; 
      P = 0.0021) and diastolic dysfunction (beta 0.0179, 95% CI 0.0001/0.036; P = 0.049), 
      cardiovascular (hazard ratio per standard deviation of galectin-3 (HR(perSD)) 
      1.60, 95% CI 1.39-1.85; P < 0.0001) and all-cause mortality (HR(perSD) 1.36, 95% 
      CI 1.25-1.47; P < 0.0001) in T2DM. No relationship between galectin-3 and cardiac 
      function was found in euglycaemia, whereas NT-proBNP consistently related to 
      reduced cardiac function. Prospective value of NT-proBNP on cardiovascular and 
      all-cause mortality was higher. NT-proBNP was superior to galectin-3 to assess 
      reduced systolic and diastolic function.
CI  - (c) 2021. The Author(s).
FAU - Schmitt, Volker H
AU  - Schmitt VH
AD  - Department of Cardiology, Cardiology I, University Medical Center, Johannes 
      Gutenberg University Mainz, Langenbeckstr. 1, 55131, Mainz, Germany.
AD  - German Center for Cardiovascular Research (DZHK), Partner Site Rhine-Main, Mainz, 
      Germany.
FAU - Prochaska, Jurgen H
AU  - Prochaska JH
AD  - German Center for Cardiovascular Research (DZHK), Partner Site Rhine-Main, Mainz, 
      Germany.
AD  - Preventive Cardiology and Preventive Medicine, Department of Cardiology, 
      University Medical Center, Johannes Gutenberg University Mainz, Langenbeckstr. 1, 
      55131, Mainz, Germany.
AD  - Center for Thrombosis and Hemostasis (CTH), University Medical Center, Johannes 
      Gutenberg University Mainz, Langenbeckstr. 1, 55131, Mainz, Germany.
FAU - Foll, Annegret S
AU  - Foll AS
AD  - Preventive Cardiology and Preventive Medicine, Department of Cardiology, 
      University Medical Center, Johannes Gutenberg University Mainz, Langenbeckstr. 1, 
      55131, Mainz, Germany.
FAU - Schulz, Andreas
AU  - Schulz A
AD  - Preventive Cardiology and Preventive Medicine, Department of Cardiology, 
      University Medical Center, Johannes Gutenberg University Mainz, Langenbeckstr. 1, 
      55131, Mainz, Germany.
AD  - Center for Thrombosis and Hemostasis (CTH), University Medical Center, Johannes 
      Gutenberg University Mainz, Langenbeckstr. 1, 55131, Mainz, Germany.
FAU - Keller, Karsten
AU  - Keller K
AD  - Department of Cardiology, Cardiology I, University Medical Center, Johannes 
      Gutenberg University Mainz, Langenbeckstr. 1, 55131, Mainz, Germany.
AD  - Center for Thrombosis and Hemostasis (CTH), University Medical Center, Johannes 
      Gutenberg University Mainz, Langenbeckstr. 1, 55131, Mainz, Germany.
AD  - Medical Clinic VII, Department of Sports Medicine, University Hospital 
      Heidelberg, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany.
FAU - Hahad, Omar
AU  - Hahad O
AD  - Department of Cardiology, Cardiology I, University Medical Center, Johannes 
      Gutenberg University Mainz, Langenbeckstr. 1, 55131, Mainz, Germany.
AD  - German Center for Cardiovascular Research (DZHK), Partner Site Rhine-Main, Mainz, 
      Germany.
FAU - Koeck, Thomas
AU  - Koeck T
AD  - German Center for Cardiovascular Research (DZHK), Partner Site Rhine-Main, Mainz, 
      Germany.
AD  - Center for Thrombosis and Hemostasis (CTH), University Medical Center, Johannes 
      Gutenberg University Mainz, Langenbeckstr. 1, 55131, Mainz, Germany.
FAU - Trobs, Sven-Oliver
AU  - Trobs SO
AD  - Department of Cardiology, Cardiology I, University Medical Center, Johannes 
      Gutenberg University Mainz, Langenbeckstr. 1, 55131, Mainz, Germany.
AD  - German Center for Cardiovascular Research (DZHK), Partner Site Rhine-Main, Mainz, 
      Germany.
AD  - Preventive Cardiology and Preventive Medicine, Department of Cardiology, 
      University Medical Center, Johannes Gutenberg University Mainz, Langenbeckstr. 1, 
      55131, Mainz, Germany.
FAU - Rapp, Steffen
AU  - Rapp S
AD  - Preventive Cardiology and Preventive Medicine, Department of Cardiology, 
      University Medical Center, Johannes Gutenberg University Mainz, Langenbeckstr. 1, 
      55131, Mainz, Germany.
AD  - Center for Thrombosis and Hemostasis (CTH), University Medical Center, Johannes 
      Gutenberg University Mainz, Langenbeckstr. 1, 55131, Mainz, Germany.
FAU - Beutel, Manfred
AU  - Beutel M
AD  - Department of Psychosomatic Medicine and Psychotherapy, University Medical 
      Center, Johannes Gutenberg University Mainz, Langenbeckstr. 1, 55131, Mainz, 
      Germany.
FAU - Pfeiffer, Norbert
AU  - Pfeiffer N
AD  - Department of Ophthalmology, University Medical Center, Johannes Gutenberg 
      University Mainz, Langenbeckstr. 1, 55131, Mainz, Germany.
FAU - Strauch, Konstantin
AU  - Strauch K
AD  - Institute of Medical Biostatistics, Epidemiology and Informatics (IMBEI), 
      University Medical Center, Johannes Gutenberg University Mainz, Obere Zahlbacher 
      Str. 69, 55131, Mainz, Germany.
FAU - Lackner, Karl J
AU  - Lackner KJ
AD  - German Center for Cardiovascular Research (DZHK), Partner Site Rhine-Main, Mainz, 
      Germany.
AD  - Institute of Clinical Chemistry and Laboratory Medicine, University Medical 
      Center, Johannes Gutenberg University Mainz, Langenbeckstr. 1, 55131, Mainz, 
      Germany.
FAU - Munzel, Thomas
AU  - Munzel T
AD  - Department of Cardiology, Cardiology I, University Medical Center, Johannes 
      Gutenberg University Mainz, Langenbeckstr. 1, 55131, Mainz, Germany. 
      tmuenzel@uni-mainz.de.
AD  - German Center for Cardiovascular Research (DZHK), Partner Site Rhine-Main, Mainz, 
      Germany. tmuenzel@uni-mainz.de.
AD  - Center for Thrombosis and Hemostasis (CTH), University Medical Center, Johannes 
      Gutenberg University Mainz, Langenbeckstr. 1, 55131, Mainz, Germany. 
      tmuenzel@uni-mainz.de.
FAU - Wild, Philipp S
AU  - Wild PS
AD  - German Center for Cardiovascular Research (DZHK), Partner Site Rhine-Main, Mainz, 
      Germany.
AD  - Preventive Cardiology and Preventive Medicine, Department of Cardiology, 
      University Medical Center, Johannes Gutenberg University Mainz, Langenbeckstr. 1, 
      55131, Mainz, Germany.
AD  - Center for Thrombosis and Hemostasis (CTH), University Medical Center, Johannes 
      Gutenberg University Mainz, Langenbeckstr. 1, 55131, Mainz, Germany.
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210924
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
RN  - 0 (Biomarkers)
RN  - 0 (Galectin 3)
RN  - 0 (Peptide Fragments)
RN  - 0 (pro-brain natriuretic peptide (1-76))
RN  - 114471-18-0 (Natriuretic Peptide, Brain)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Biomarkers/blood
MH  - Cardiovascular Diseases/*diagnosis/etiology/physiopathology
MH  - Diabetes Mellitus, Type 2/complications/*physiopathology
MH  - Diastole
MH  - Female
MH  - Follow-Up Studies
MH  - Galectin 3/*blood
MH  - Heart/*physiopathology
MH  - Heart Disease Risk Factors
MH  - Heart Function Tests/*methods
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Natriuretic Peptide, Brain/*blood
MH  - Peptide Fragments/*blood
MH  - Prediabetic State/complications/*physiopathology
MH  - Systole
PMC - PMC8463561
COIS- J.H.P. received funding for lecturing by Bayer AG and Boehringer Ingelheim 
      outside the topic of this work. P.S.W. reports the submitted work Grants from 
      Bayer AG, non-financial grants from Philips Medical Systems, grants and 
      consulting fees from Boehringer Ingelheim, Grants and consulting fees from 
      Novartis Pharma, Grants and consulting fees from Sanofi-Aventis, Grants, 
      consulting and lecturing fees from Bayer Health Care, Grants from Daiichi Sankyo 
      Europe, consulting fees from Astra Zeneca, consulting fees and non-financial 
      support from Diasorin and non-financial support from I.E.M., outside the 
      submitted work. S.O.T has received lecture fees for Philips AG outside the 
      submitted work. All other authors declare no disclosures that could be perceived 
      as conflict of interest in the context of the present work.
EDAT- 2021/09/26 06:00
MHDA- 2022/01/07 06:00
PMCR- 2021/09/24
CRDT- 2021/09/25 06:01
PHST- 2021/05/14 00:00 [received]
PHST- 2021/09/02 00:00 [accepted]
PHST- 2021/09/25 06:01 [entrez]
PHST- 2021/09/26 06:00 [pubmed]
PHST- 2022/01/07 06:00 [medline]
PHST- 2021/09/24 00:00 [pmc-release]
AID - 10.1038/s41598-021-98227-x [pii]
AID - 98227 [pii]
AID - 10.1038/s41598-021-98227-x [doi]
PST - epublish
SO  - Sci Rep. 2021 Sep 24;11(1):19012. doi: 10.1038/s41598-021-98227-x.