PMID- 34562655
OWN - NLM
STAT- MEDLINE
DCOM- 20220128
LR  - 20220128
IS  - 1090-2104 (Electronic)
IS  - 0006-291X (Linking)
VI  - 578
DP  - 2021 Nov 12
TI  - WJCPR11 reverses the TNF-alpha-induced inhibition of adipocyte differentiation and 
      glucose uptake.
PG  - 150-156
LID - S0006-291X(21)01328-0 [pii]
LID - 10.1016/j.bbrc.2021.09.034 [doi]
AB  - Berberine is a natural isoquinoline alkaloid present in various herbs and is 
      effective against metabolic syndrome in the pre-diabetic stage and high insulin 
      resistance. The present study aimed to determine the effectiveness of WJCPR11, a 
      berberine derivative that is commonly used for diabetes treatment, in 
      ameliorating insulin resistance and diabetes treatment. WJCPR11 promoted 
      adipocyte differentiation to a higher extent than other berberine derivatives and 
      showed no noticeable toxicity in its effective concentration range. It increased 
      the mRNA expression levels and protein abundance of adipogenic markers, including 
      peroxisome proliferator-activated receptor gamma (PPARgamma), glucose transporter type 4 
      (GluT4), and fatty acid synthase (FAS), and markedly enhanced the level of 
      adiponectin, a distinct marker of insulin sensitivity. Meanwhile, the mRNA levels 
      of inflammatory markers such as plasminogen activator inhibitor-1 (PAI-1), 
      monocyte chemoattractant protein-1 (MCP-1), and interleukin 6 (IL-6) were reduced 
      after WJCPR11 treatment. Furthermore, the tumor necrosis factor-alpha (TNF-alpha)-induced 
      inhibition of adipocyte differentiation and downregulation of glucose uptake were 
      markedly reversed by WJCPR11 treatment. Collectively, the findings of this study 
      indicate that WJCPR11 has great potential for diabetes treatment.
CI  - Copyright (c) 2021 Elsevier Inc. All rights reserved.
FAU - Nam, Seo Woo
AU  - Nam SW
AD  - Department of Engineering, College of Carbon Convergence Engineering, Wonkwang 
      University, Iksan, 54538, Republic of Korea. Electronic address: 
      namseo214@gmail.com.
FAU - Kim, Min Seuk
AU  - Kim MS
AD  - Department of Oral Physiology, Institute of Biomaterial-Implant, School of 
      Dentistry, Wonkwang University, Iksan, 54538, Republic of Korea.
FAU - Han, Younho
AU  - Han Y
AD  - Department of Oral Pharmacology, Institute of Biomaterial-Implant, School of 
      Dentistry, Wonkwang University, Iksan, 54538, Republic of Korea. Electronic 
      address: daks262@wku.ac.kr.
FAU - Lee, Kwang Youl
AU  - Lee KY
AD  - College of Pharmacy & Research Institute of Pharmaceutical Sciences, Chonnam 
      National University, Gwangju, 61186, Republic of Korea. Electronic address: 
      kwanglee@jnu.ac.kr.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210920
PL  - United States
TA  - Biochem Biophys Res Commun
JT  - Biochemical and biophysical research communications
JID - 0372516
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 0I8Y3P32UF (Berberine)
RN  - IY9XDZ35W2 (Glucose)
SB  - IM
MH  - Adipocytes/*cytology/drug effects/metabolism
MH  - Animals
MH  - Berberine/*analogs & derivatives/pharmacology
MH  - Cell Differentiation/physiology
MH  - Cells, Cultured
MH  - Glucose/*metabolism
MH  - Insulin Resistance
MH  - Mice
MH  - Prediabetic State/*drug therapy/metabolism/pathology
MH  - Tumor Necrosis Factor-alpha/*metabolism
OTO - NOTNLM
OT  - Adipocyte differentiation
OT  - Berberine
OT  - Glucose uptake
OT  - TNF-alpha
OT  - WJCPR11
COIS- Declaration of competing interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2021/09/26 06:00
MHDA- 2022/01/29 06:00
CRDT- 2021/09/25 20:14
PHST- 2021/08/23 00:00 [received]
PHST- 2021/09/15 00:00 [revised]
PHST- 2021/09/16 00:00 [accepted]
PHST- 2021/09/26 06:00 [pubmed]
PHST- 2022/01/29 06:00 [medline]
PHST- 2021/09/25 20:14 [entrez]
AID - S0006-291X(21)01328-0 [pii]
AID - 10.1016/j.bbrc.2021.09.034 [doi]
PST - ppublish
SO  - Biochem Biophys Res Commun. 2021 Nov 12;578:150-156. doi: 
      10.1016/j.bbrc.2021.09.034. Epub 2021 Sep 20.