PMID- 34563210 OWN - NLM STAT- MEDLINE DCOM- 20220210 LR - 20220210 IS - 1546-0096 (Electronic) IS - 1546-0096 (Linking) VI - 19 IP - 1 DP - 2021 Sep 25 TI - Predictive value of Albumin-Bilirubin grade for intravenous immunoglobulin resistance in a large cohort of patients with Kawasaki disease: a prospective study. PG - 147 LID - 10.1186/s12969-021-00638-7 [doi] LID - 147 AB - BACKGROUND: Intravenous immunoglobulin (IVIG) resistance prediction is one of the primary clinical issues and study hotspots in KD. This study aimed to prospectively investigate the value of albumin-bilirubin grade (ALBI) in predicting IVIG resistance in KD and to assess whether ALBI has more predictive value or accuracy than either ALB or TBil alone in predicting IVIG resistance. METHODS: A total of 823 patients with KD were prospectively enrolled. The clinical and laboratory data were compared between the IVIG-response group (n = 708) and the IVIG-resistance group (n = 115). Multivariate logistic regression analysis was performed to identify the independent risk factors for IVIG resistance. Receiver operating characteristic (ROC) curves analysis was applied to assess the validity of ALBI, ALB, and TBil in predicting IVIG resistance. RESULTS: ALBI was significantly higher in patients with IVIG resistance and was identified as an independent risk factor for IVIG resistance in KD. The parameter of ALBI >/= - 2.57 (AUC: 0.705, 95 %CI: 0.672-0.736), ALB /= 16.0micromol/L (AUC: 0.626, 95 %CI: 0.592-0.659), produced a sensitivity, specificity, PPV, and NPV of 0.617, 0.657, 0.226 and 0.914; 0.374, 0.850, 0.289 and 0.893; 0.269, 0.941, 0.425 and 0.888, respectively. CONCLUSIONS: A higher ALBI was an independent risk factor for IVIG resistance in KD. It yielded better predictive ability than ALB and TBil alone for initial IVIG resistance. CI - (c) 2021. The Author(s). FAU - Yan, Yu AU - Yan Y AD - Department of Pediatric Cardiology, West China Second University Hospital, Sichuan University, 610041, Chengdu, Sichuan, China. AD - West China Medical School of Sichuan University, 610041, Chengdu, Sichuan, China. FAU - Qiao, Lina AU - Qiao L AD - Department of Pediatric Cardiology, West China Second University Hospital, Sichuan University, 610041, Chengdu, Sichuan, China. AD - Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Sichuan, 610041, Chengdu, China. AD - Key Laboratory of Development and Diseases of Women and Children of Sichuan Province, West China Second University Hospital, Sichuan University, 610041, Chengdu, Sichuan, China. FAU - Hua, Yimin AU - Hua Y AD - Department of Pediatric Cardiology, West China Second University Hospital, Sichuan University, 610041, Chengdu, Sichuan, China. AD - Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Sichuan, 610041, Chengdu, China. AD - Key Laboratory of Development and Diseases of Women and Children of Sichuan Province, West China Second University Hospital, Sichuan University, 610041, Chengdu, Sichuan, China. AD - The Cardiac development and early intervention unit, West China Second University Hospital, West China Institute of Women and Children's Health, Sichuan University, 610041, Chengdu, Sichuan, China. FAU - Shao, Shuran AU - Shao S AD - Department of Pediatric Cardiology, West China Second University Hospital, Sichuan University, 610041, Chengdu, Sichuan, China. AD - West China Medical School of Sichuan University, 610041, Chengdu, Sichuan, China. FAU - Zhang, Nanjun AU - Zhang N AD - Department of Pediatric Cardiology, West China Second University Hospital, Sichuan University, 610041, Chengdu, Sichuan, China. AD - West China Medical School of Sichuan University, 610041, Chengdu, Sichuan, China. FAU - Wu, Mei AU - Wu M AD - Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Sichuan, 610041, Chengdu, China. AD - Department of Pediatrics, West China Second University Hospital, Sichuan University, 610041, Chengdu, Sichuan, China. FAU - Liu, Lei AU - Liu L AD - Department of Pediatric Cardiology, West China Second University Hospital, Sichuan University, 610041, Chengdu, Sichuan, China. AD - West China Medical School of Sichuan University, 610041, Chengdu, Sichuan, China. FAU - Zhou, Kaiyu AU - Zhou K AD - Department of Pediatric Cardiology, West China Second University Hospital, Sichuan University, 610041, Chengdu, Sichuan, China. AD - Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Sichuan, 610041, Chengdu, China. AD - Key Laboratory of Development and Diseases of Women and Children of Sichuan Province, West China Second University Hospital, Sichuan University, 610041, Chengdu, Sichuan, China. AD - The Cardiac development and early intervention unit, West China Second University Hospital, West China Institute of Women and Children's Health, Sichuan University, 610041, Chengdu, Sichuan, China. FAU - Liu, Xiaoliang AU - Liu X AD - Department of Pediatric Cardiology, West China Second University Hospital, Sichuan University, 610041, Chengdu, Sichuan, China. sdigjoy@qq.com. AD - Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Sichuan, 610041, Chengdu, China. sdigjoy@qq.com. AD - Key Laboratory of Development and Diseases of Women and Children of Sichuan Province, West China Second University Hospital, Sichuan University, 610041, Chengdu, Sichuan, China. sdigjoy@qq.com. AD - Dept. of Pediatrics, West China Second University Hospital, Sichuan University, No. 20, 3rd section, South Renmin Road, 610041, Chengdu, China. sdigjoy@qq.com. FAU - Wang, Chuan AU - Wang C AD - Department of Pediatric Cardiology, West China Second University Hospital, Sichuan University, 610041, Chengdu, Sichuan, China. 805101396@qq.com. AD - Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Sichuan, 610041, Chengdu, China. 805101396@qq.com. AD - Key Laboratory of Development and Diseases of Women and Children of Sichuan Province, West China Second University Hospital, Sichuan University, 610041, Chengdu, Sichuan, China. 805101396@qq.com. AD - The Cardiac development and early intervention unit, West China Second University Hospital, West China Institute of Women and Children's Health, Sichuan University, 610041, Chengdu, Sichuan, China. 805101396@qq.com. AD - Dept. of Pediatrics, West China Second University Hospital, Sichuan University, No. 20, 3rd section, South Renmin Road, 610041, Chengdu, China. 805101396@qq.com. LA - eng GR - 2018YFC1002301/National Key R&D Program of China/ GR - 81800288/National Natural Science Foundation of China/ GR - 82070324/National Natural Science Foundation of China/ GR - 81971457/National Natural Science Foundation of China/ GR - 2017SZ0117/Science-technology Support Plan Projects in Sichuan province/ GR - 2019YFS0243/Science-technology Support Plan Projects in Sichuan province/ GR - 2020YFS0101/Science-technology Support Plan Projects in Sichuan province/ GR - 2020YJ0234/Science-technology Support Plan Projects in Sichuan province/ PT - Journal Article DEP - 20210925 PL - England TA - Pediatr Rheumatol Online J JT - Pediatric rheumatology online journal JID - 101248897 RN - 0 (Immunoglobulins, Intravenous) RN - 0 (Serum Albumin) RN - RFM9X3LJ49 (Bilirubin) SB - IM MH - Bilirubin/*blood MH - Child, Preschool MH - Cohort Studies MH - Drug Resistance MH - Female MH - Humans MH - Immunoglobulins, Intravenous/*therapeutic use MH - Infant MH - Male MH - Mucocutaneous Lymph Node Syndrome/*blood/*drug therapy MH - Predictive Value of Tests MH - Prospective Studies MH - Serum Albumin/*analysis PMC - PMC8467146 OTO - NOTNLM OT - Kawasaki disease OT - albumin-bilirubin grade OT - intravenous immunoglobulin resistance COIS- None of authors declared any conflict of interests. EDAT- 2021/09/27 06:00 MHDA- 2022/02/11 06:00 PMCR- 2021/09/25 CRDT- 2021/09/26 20:27 PHST- 2021/04/28 00:00 [received] PHST- 2021/09/06 00:00 [accepted] PHST- 2021/09/26 20:27 [entrez] PHST- 2021/09/27 06:00 [pubmed] PHST- 2022/02/11 06:00 [medline] PHST- 2021/09/25 00:00 [pmc-release] AID - 10.1186/s12969-021-00638-7 [pii] AID - 638 [pii] AID - 10.1186/s12969-021-00638-7 [doi] PST - epublish SO - Pediatr Rheumatol Online J. 2021 Sep 25;19(1):147. doi: 10.1186/s12969-021-00638-7.