PMID- 34564728
OWN - NLM
STAT- MEDLINE
DCOM- 20220602
LR  - 20220723
IS  - 1460-2199 (Electronic)
IS  - 1047-3211 (Print)
IS  - 1047-3211 (Linking)
VI  - 32
IP  - 11
DP  - 2022 May 30
TI  - Cellular Substrates of Functional Network Integration and Memory in Temporal Lobe 
      Epilepsy.
PG  - 2424-2436
LID - 10.1093/cercor/bhab349 [doi]
AB  - Temporal lobe epilepsy (TLE) patients are at risk of memory deficits, which have 
      been linked to functional network disturbances, particularly of integration of 
      the default mode network (DMN). However, the cellular substrates of functional 
      network integration are unknown. We leverage a unique cross-scale dataset of 
      drug-resistant TLE patients (n = 31), who underwent pseudo resting-state 
      functional magnetic resonance imaging (fMRI), resting-state 
      magnetoencephalography (MEG) and/or neuropsychological testing before 
      neurosurgery. fMRI and MEG underwent atlas-based connectivity analyses. 
      Functional network centrality of the lateral middle temporal gyrus, part of the 
      DMN, was used as a measure of local network integration. Subsequently, 
      non-pathological cortical tissue from this region was used for single cell 
      morphological and electrophysiological patch-clamp analysis, assessing 
      integration in terms of total dendritic length and action potential rise speed. 
      As could be hypothesized, greater network centrality related to better memory 
      performance. Moreover, greater network centrality correlated with more 
      integrative properties at the cellular level across patients. We conclude that 
      individual differences in cognitively relevant functional network integration of 
      a DMN region are mirrored by differences in cellular integrative properties of 
      this region in TLE patients. These findings connect previously separate scales of 
      investigation, increasing translational insight into focal pathology and 
      large-scale network disturbances in TLE.
CI  - (c) The Author(s) 2021. Published by Oxford University Press. All rights reserved. 
      For permissions, please e-mail: journals.permissions@oup.com.
FAU - Douw, Linda
AU  - Douw L
AUID- ORCID: 0000-0001-7058-4062
AD  - Department of Anatomy and Neurosciences, Amsterdam UMC, Vrije Universiteit 
      Amsterdam, Amsterdam Neuroscience, 1081 HV, Amsterdam, the Netherlands.
AD  - Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, 
      Massachusetts General Hospital, 02129 MA, Charlestown, USA.
FAU - Nissen, Ida A
AU  - Nissen IA
AD  - Department of Clinical Neurophysiology and MEG Center, Amsterdam UMC, Vrije 
      Universiteit Amsterdam, Amsterdam Neuroscience, 1081 HV, Amsterdam, the 
      Netherlands.
FAU - Fitzsimmons, Sophie M D D
AU  - Fitzsimmons SMDD
AD  - Department of Anatomy and Neurosciences, Amsterdam UMC, Vrije Universiteit 
      Amsterdam, Amsterdam Neuroscience, 1081 HV, Amsterdam, the Netherlands.
FAU - Santos, Fernando A N
AU  - Santos FAN
AD  - Department of Anatomy and Neurosciences, Amsterdam UMC, Vrije Universiteit 
      Amsterdam, Amsterdam Neuroscience, 1081 HV, Amsterdam, the Netherlands.
FAU - Hillebrand, Arjan
AU  - Hillebrand A
AD  - Department of Clinical Neurophysiology and MEG Center, Amsterdam UMC, Vrije 
      Universiteit Amsterdam, Amsterdam Neuroscience, 1081 HV, Amsterdam, the 
      Netherlands.
FAU - van Straaten, Elisabeth C W
AU  - van Straaten ECW
AD  - Department of Clinical Neurophysiology and MEG Center, Amsterdam UMC, Vrije 
      Universiteit Amsterdam, Amsterdam Neuroscience, 1081 HV, Amsterdam, the 
      Netherlands.
FAU - Stam, Cornelis J
AU  - Stam CJ
AD  - Department of Clinical Neurophysiology and MEG Center, Amsterdam UMC, Vrije 
      Universiteit Amsterdam, Amsterdam Neuroscience, 1081 HV, Amsterdam, the 
      Netherlands.
FAU - De Witt Hamer, Philip C
AU  - De Witt Hamer PC
AD  - Department of Neurosurgery, Amsterdam UMC, Vrije Universiteit Amsterdam, 
      Amsterdam Neuroscience, VUmc Cancer Center Amsterdam Brain Tumor Center 
      Amsterdam, 1081 HV, Amsterdam, the Netherlands.
FAU - Baayen, Johannes C
AU  - Baayen JC
AD  - Department of Neurosurgery, Amsterdam UMC, Vrije Universiteit Amsterdam, 
      Amsterdam Neuroscience, VUmc Cancer Center Amsterdam Brain Tumor Center 
      Amsterdam, 1081 HV, Amsterdam, the Netherlands.
FAU - Klein, Martin
AU  - Klein M
AD  - Department of Medical Psychology, Amsterdam UMC, Vrije Universiteit Amsterdam, 
      Amsterdam Neuroscience, VUmc Cancer Center Amsterdam Brain Tumor Center 
      Amsterdam, 1081 HV, Amsterdam, the Netherlands.
FAU - Reijneveld, Jaap C
AU  - Reijneveld JC
AD  - Department of Neurology, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam 
      Neuroscience, VUmc Cancer Center Amsterdam Brain Tumor Center Amsterdam, 1081 HV, 
      Amsterdam, the Netherlands.
AD  - Stichting Epilepsie Instellingen Nederland (SEIN), Heemstede 2103 SW, Heemstede, 
      the Netherlands.
FAU - Heyer, Djai B
AU  - Heyer DB
AUID- ORCID: 0000-0002-8118-1450
AD  - Department of Integrative Neurophysiology, Center for Neurogenomics and Cognitive 
      Research (CNCR), Vrije Universiteit Amsterdam, Amsterdam Neuroscience, 1081 HV, 
      Amsterdam, the Netherlands.
FAU - Verhoog, Matthijs B
AU  - Verhoog MB
AD  - Department of Integrative Neurophysiology, Center for Neurogenomics and Cognitive 
      Research (CNCR), Vrije Universiteit Amsterdam, Amsterdam Neuroscience, 1081 HV, 
      Amsterdam, the Netherlands.
AD  - Department of Human Biology, Division of Cell Biology, Neuroscience Institute, 
      University of Cape Town, 7935, Cape Town, South Africa.
FAU - Wilbers, Rene
AU  - Wilbers R
AD  - Department of Integrative Neurophysiology, Center for Neurogenomics and Cognitive 
      Research (CNCR), Vrije Universiteit Amsterdam, Amsterdam Neuroscience, 1081 HV, 
      Amsterdam, the Netherlands.
FAU - Hunt, Sarah
AU  - Hunt S
AD  - Department of Integrative Neurophysiology, Center for Neurogenomics and Cognitive 
      Research (CNCR), Vrije Universiteit Amsterdam, Amsterdam Neuroscience, 1081 HV, 
      Amsterdam, the Netherlands.
FAU - Mansvelder, Huibert D
AU  - Mansvelder HD
AD  - Department of Integrative Neurophysiology, Center for Neurogenomics and Cognitive 
      Research (CNCR), Vrije Universiteit Amsterdam, Amsterdam Neuroscience, 1081 HV, 
      Amsterdam, the Netherlands.
FAU - Geurts, Jeroen J G
AU  - Geurts JJG
AD  - Department of Anatomy and Neurosciences, Amsterdam UMC, Vrije Universiteit 
      Amsterdam, Amsterdam Neuroscience, 1081 HV, Amsterdam, the Netherlands.
FAU - de Kock, Christiaan P J
AU  - de Kock CPJ
AD  - Department of Integrative Neurophysiology, Center for Neurogenomics and Cognitive 
      Research (CNCR), Vrije Universiteit Amsterdam, Amsterdam Neuroscience, 1081 HV, 
      Amsterdam, the Netherlands.
FAU - Goriounova, Natalia A
AU  - Goriounova NA
AD  - Department of Integrative Neurophysiology, Center for Neurogenomics and Cognitive 
      Research (CNCR), Vrije Universiteit Amsterdam, Amsterdam Neuroscience, 1081 HV, 
      Amsterdam, the Netherlands.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Cereb Cortex
JT  - Cerebral cortex (New York, N.Y. : 1991)
JID - 9110718
SB  - IM
MH  - *Drug Resistant Epilepsy
MH  - *Epilepsy, Temporal Lobe/diagnostic imaging
MH  - Humans
MH  - Magnetic Resonance Imaging/methods
MH  - Magnetoencephalography
MH  - Temporal Lobe
PMC - PMC9157285
OTO - NOTNLM
OT  - action potential kinetics
OT  - cellular morphology
OT  - connectome
OT  - graph theory
OT  - resting-state fMRI
EDAT- 2021/09/27 06:00
MHDA- 2022/06/03 06:00
PMCR- 2021/09/25
CRDT- 2021/09/26 21:07
PHST- 2021/05/18 00:00 [received]
PHST- 2021/08/19 00:00 [revised]
PHST- 2021/08/22 00:00 [accepted]
PHST- 2021/09/27 06:00 [pubmed]
PHST- 2022/06/03 06:00 [medline]
PHST- 2021/09/26 21:07 [entrez]
PHST- 2021/09/25 00:00 [pmc-release]
AID - 6375261 [pii]
AID - bhab349 [pii]
AID - 10.1093/cercor/bhab349 [doi]
PST - ppublish
SO  - Cereb Cortex. 2022 May 30;32(11):2424-2436. doi: 10.1093/cercor/bhab349.