PMID- 34564818
OWN - NLM
STAT- MEDLINE
DCOM- 20220830
LR  - 20220928
IS  - 1522-1709 (Electronic)
IS  - 1520-9512 (Linking)
VI  - 26
IP  - 3
DP  - 2022 Sep
TI  - Insomnia symptoms are associated with an increased risk of type 2 diabetes 
      mellitus among adults aged 50 and older.
PG  - 1409-1416
LID - 10.1007/s11325-021-02497-8 [doi]
AB  - PURPOSE: To evaluate the association of the different degrees of insomnia 
      symptoms with subsequent incidence of type 2 diabetes mellitus (T2DM). METHODS: 
      The data were extracted from Health and Retirement Study 2006-2014 waves. The 
      association of insomnia symptoms with T2DM incidence was evaluated by the 
      competing risk model with cumulative incidence function (death was considered a 
      competing event) and Cox proportional hazard model with the Kaplan-Meier method. 
      Population attributable fraction (PAF) was calculated. All analyses related to 
      our study were conducted between November 2020 and January 2021. RESULTS: A total 
      of 14,112 patients were included in this study, with an average follow-up of 
      6.4 years, and the incidence density was 17.9 per 1000 person-years. Insomnia 
      symptoms were positively associated with T2DM incidence compared with those with 
      no insomnia symptoms, regardless of competing risk model (>/= 1 symptoms: 
      sub-distribution hazard ratio (SHR) 1.13; 95% confidence interval (CI) 1.02-1.26; 
      P-trend = 0.012) and Cox proportional hazard model (>/= 1 symptoms: hazard ratio 
      (HR) 1.13; 95% CI 1.02-1.26; P-trend = 0.013). The cumulative incidence function 
      (Gray's test, p < 0.001) and Kaplan-Meier estimate (log-rank test, p < 0.001) 
      also presented this positive relationship. This positive association was more 
      apparent in women and participants with ages from 50 to 65 years. The PAF was 
      4.1% with 95% CI (0.7-7.9%). CONCLUSIONS: Insomnia symptoms may be an important 
      risk factor for the development of T2DM, which is unbiased by the death competing 
      risk. These findings suggest that management of sleep problems may be an 
      important part of strategies to prevent T2DM.
CI  - (c) 2021. The Author(s), under exclusive licence to Springer Nature Switzerland AG.
FAU - Yao, Wenqin
AU  - Yao W
AD  - Department of Epidemiology and Health Statistics, The School of Public Health of 
      Qingdao University, No. 308 Ningxia Road, Qingdao, 266071, Shandong, China.
FAU - Luo, Jia
AU  - Luo J
AD  - Department of Epidemiology and Health Statistics, The School of Public Health of 
      Qingdao University, No. 308 Ningxia Road, Qingdao, 266071, Shandong, China.
FAU - Yu, Xiaohui
AU  - Yu X
AD  - Department of Epidemiology and Health Statistics, The School of Public Health of 
      Qingdao University, No. 308 Ningxia Road, Qingdao, 266071, Shandong, China.
FAU - Jiang, Wenjie
AU  - Jiang W
AD  - Department of Epidemiology and Health Statistics, The School of Public Health of 
      Qingdao University, No. 308 Ningxia Road, Qingdao, 266071, Shandong, China.
FAU - Zhang, Dongfeng
AU  - Zhang D
AUID- ORCID: 0000-0001-9308-9371
AD  - Department of Epidemiology and Health Statistics, The School of Public Health of 
      Qingdao University, No. 308 Ningxia Road, Qingdao, 266071, Shandong, China. 
      zhangdf1961@126.com.
LA  - eng
PT  - Journal Article
DEP - 20210926
PL  - Germany
TA  - Sleep Breath
JT  - Sleep & breathing = Schlaf & Atmung
JID - 9804161
SB  - IM
MH  - Adult
MH  - Aged
MH  - *Diabetes Mellitus, Type 2
MH  - Female
MH  - Humans
MH  - Incidence
MH  - Kaplan-Meier Estimate
MH  - Middle Aged
MH  - Proportional Hazards Models
MH  - Risk Factors
MH  - *Sleep Initiation and Maintenance Disorders
OTO - NOTNLM
OT  - Competing risk model
OT  - Cox proportional hazard model
OT  - Health and Retirement Study
OT  - Insomnia symptoms
OT  - Type 2 diabetes mellitus
EDAT- 2021/09/27 06:00
MHDA- 2022/08/31 06:00
CRDT- 2021/09/26 21:11
PHST- 2021/07/17 00:00 [received]
PHST- 2021/09/21 00:00 [accepted]
PHST- 2021/09/09 00:00 [revised]
PHST- 2021/09/27 06:00 [pubmed]
PHST- 2022/08/31 06:00 [medline]
PHST- 2021/09/26 21:11 [entrez]
AID - 10.1007/s11325-021-02497-8 [pii]
AID - 10.1007/s11325-021-02497-8 [doi]
PST - ppublish
SO  - Sleep Breath. 2022 Sep;26(3):1409-1416. doi: 10.1007/s11325-021-02497-8. Epub 
      2021 Sep 26.