PMID- 34565726 OWN - NLM STAT- MEDLINE DCOM- 20210928 LR - 20240321 IS - 1672-7347 (Print) IS - 1672-7347 (Linking) VI - 46 IP - 8 DP - 2021 Aug 28 TI - Olfactory dysfunction is a risk factor for the comorbidity of mild cognitive impairment and Type 2 diabetes mellitus. PG - 831-837 LID - 1672-7347(2021)08-0831-07 [pii] LID - 10.11817/j.issn.1672-7347.2021.200046 [doi] AB - OBJECTIVES: Diabetes can accelerate cognitive decline and hence affect the prognosis of patients with Type 2 diabetes mellitus (T2DM). Olfactory assessment can facilitate the early identification of cognitive impairment among T2DM patients. This study aims to evaluate the effects of olfactory function on mild cognitive impairment (MCI) in patients with T2DM. METHODS: A total of 472 T2DM patients who were hospitalized in a first-class hospital in Changsha City from June 2018 to June 2019 were enrolled for this study. Olfactory function and cognitive function were assessed by the alcohol sniff test and the Montreal Cognitive Assessment (MoCA) scale, respectively. Participants were categorized into a comorbidity of MCI and T2DM group and a T2DM group. General information was collected and some biochemical indices were tested. Difference in the alcohol sniff test score between the 2 groups was assessed by 2-sample t-test. Difference in the presence of olfactory dysfunction between the 2 groups was assessed by chi(2) test, and multivariable logistic regression was used to determine the relevant factors contributing to the comorbidity of MCI and T2DM. RESULTS: Of the 472 participants, 162 were identified with MCI, making the comorbidity rate at 34.3%. Values of isopropyl alcohol sniff test were significantly different between the 2 groups [(9.15+/-3.22) cm vs (21.03+/-4.36) cm, P<0.05]. The number of patients with olfactory dysfunction also differed significantly between the 2 groups (120 vs 50). After adjustment for age, educational level, T2DM duration, fasting insulin, and glycosylated hemoglobin (HbA1c), multivariate logistic regression analysis showed older age (OR=1.14, 95% CI 1.09 to 1.20), longer course of diabetes (OR=1.21, 95% CI 1.12 to 1.31), and olfactory-impaired (OR=4.61, 95% CI 3.04 to 6.18) were independent risk factors for T2DM combined with MCI, and the high education level (OR=0.26, 95% CI 0.15 to 0.38) was an independent protective factor for T2DM combined with MCI. CONCLUSIONS: Olfactory dysfunction is an independent risk factor for the comorbidity of MCI and T2DM. Special attention should be paid to those with olfactory dysfunction when carrying out cognitive interventions in T2DM patients. FAU - Gong, Lina AU - Gong L AD - Intensive Care Unit, Department of Neurology, Third Xiangya Hospital, Central South University, Changsha 410013. 188120407@qq.com. FAU - Xie, Jianfei AU - Xie J AD - Department of Nursing, Third Xiangya Hospital, Central South University, Changsha 410013. FAU - Liu, Jia AU - Liu J AD - Department of Transplantation, Third Xiangya Hospital, Central South University, Changsha 410013. FAU - Tang, Guanxiu AU - Tang G AD - Department of Gerontology, Third Xiangya Hospital, Central South University, Changsha 410013, China. FAU - Lin, Wanli AU - Lin W AD - Intensive Care Unit, Department of Neurology, Third Xiangya Hospital, Central South University, Changsha 410013. 3443114@qq.com. FAU - Zhang, Zhen AU - Zhang Z AD - Intensive Care Unit, Department of Neurology, Third Xiangya Hospital, Central South University, Changsha 410013. LA - eng LA - chi GR - 2019JJ50929/the Natural Science Foundation of Hunan Province, China/ PT - Journal Article TT - 嗅觉障碍是2型糖尿病合并轻度认知功能障碍的危险因素. PL - China TA - Zhong Nan Da Xue Xue Bao Yi Xue Ban JT - Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences JID - 101230586 SB - IM MH - Aged MH - *Cognitive Dysfunction/epidemiology/etiology MH - Comorbidity MH - *Diabetes Mellitus, Type 2/complications/epidemiology MH - Humans MH - *Olfaction Disorders/epidemiology/etiology MH - Risk Factors PMC - PMC10929969 OAB - OBJECTIVE: Diabetes can accelerate cognitive decline and hence affect the prognosis of patients with Type 2 diabetes mellitus (T2DM). Olfactory assessment can facilitate the early identification of cognitive impairment among T2DM patients. This study aims to evaluate the effects of olfactory function on mild cognitive impairment (MCI) in patients with T2DM. METHODS: A total of 472 T2DM patients who were hospitalized in a first-class hospital in Changsha City from June 2018 to June 2019 were enrolled for this study. Olfactory function and cognitive function were assessed by the alcohol sniff test and the Montreal Cognitive Assessment (MoCA) scale, respectively. Participants were categorized into a comorbidity of MCI and T2DM group and a T2DM group. General information was collected and some biochemical indices were tested. Difference in the alcohol sniff test score between the 2 groups was assessed by 2-sample t-test. Difference in the presence of olfactory dysfunction between the 2 groups was assessed by chi (2) test, and multivariable logistic regression was used to determine the relevant factors contributing to the comorbidity of MCI and T2DM. RESULTS: Of the 472 participants, 162 were identified with MCI, making the comorbidity rate at 34.3%. Values of isopropyl alcohol sniff test were significantly different between the 2 groups [(9.15+/-3.22) cm vs (21.03+/-4.36) cm, P<0.05]. The number of patients with olfactory dysfunction also differed significantly between the 2 groups (120 vs 50). After adjustment for age, educational level, T2DM duration, fasting insulin, and glycosylated hemoglobin (HbA1c), multivariate logistic regression analysis showed older age (OR=1.14, 95% CI 1.09 to 1.20), longer course of diabetes (OR=1.21, 95% CI 1.12 to 1.31), and olfactory-impaired (OR=4.61, 95% CI 3.04 to 6.18) were independent risk factors for T2DM combined with MCI, and the high education level (OR=0.26, 95% CI 0.15 to 0.38) was an independent protective factor for T2DM combined with MCI. CONCLUSION: Olfactory dysfunction is an independent risk factor for the comorbidity of MCI and T2DM. Special attention should be paid to those with olfactory dysfunction when carrying out cognitive interventions in T2DM patients. OABL- eng OTO - NOTNLM OT - Type 2 diabetes mellitus OT - mild cognitive impairment OT - olfactory dysfunction COIS- 作者声称无任何利益冲突。 EDAT- 2021/09/28 06:00 MHDA- 2021/09/29 06:00 PMCR- 2021/08/28 CRDT- 2021/09/27 05:48 PHST- 2021/09/27 05:48 [entrez] PHST- 2021/09/28 06:00 [pubmed] PHST- 2021/09/29 06:00 [medline] PHST- 2021/08/28 00:00 [pmc-release] AID - 1672-7347(2021)08-0831-07 [pii] AID - 10.11817/j.issn.1672-7347.2021.200046 [doi] PST - ppublish SO - Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2021 Aug 28;46(8):831-837. doi: 10.11817/j.issn.1672-7347.2021.200046.