PMID- 34567172
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210929
IS  - 1735-0328 (Print)
IS  - 1726-6890 (Electronic)
IS  - 1726-6882 (Linking)
VI  - 20
IP  - 2
DP  - 2021 Spring
TI  - Simultaneous Analysis of 10 Priority PAHs in Iranian Sangak Bread Samples by 
      Developing a GC-MS Method.
PG  - 433-440
LID - 10.22037/ijpr.2020.113074.14097 [doi]
AB  - Human exposure to polycyclic aromatic hydrocarbons (PAHs) is known as a 
      carcinogen risk factor. In this study, a gas chromatography-mass spectrometry 
      (GC-MS) technique combined with the QuEChERS extraction method was developed for 
      concurrent analysis of 10 polycyclic aromatic hydrocarbons (PAHs) in Iranian 
      traditional Sangak bread samples. The method was validated by determining 
      different parameters, including; linearity, accuracy, precision, limit of 
      detection (LOD) and limit of quantitation (LOQ). Calibration curves showed a 
      linear relationship in the concentration range of 10-500 ng/g with a coefficient 
      of determination (R(2)) ranged between 0.994 and 0.999. The obtained mean 
      recoveries were 92-106% with the relative standard deviations (RSDs) in the range 
      of 3-7% with an acceptable precision (RSD < 20%). The Limit of detections (LODs) 
      for different PAHs were between 0.14-0.78 ng/g, while the limit of quantitation 
      (LOQ) was 0.46-2.60 ng/g. Matrix effect studies showed that the analytes 
      concluded signal suppressions or enhancements. Therefore, spiked calibration 
      curves were used for overcoming this issue. The result of Sangak bread samples 
      analysis using the validated method showed that 9 (19.4%) out of 47 Sangak bread 
      samples were contaminated with phenanthrene (PHE) and anthracene (ANT) at the 
      mean level of 10.08 +/- 6.38 ng/g which were higher than the permissible limit of 
      European Commission regulatory control value for BaP (1 mug/kg of wet weight) in 
      processed cereal-based foods and baby foods for infants and young children.
FAU - Peiravian, Farzad
AU  - Peiravian F
AD  - Department of Pharmacoeconomics and Pharma Management, School of Pharmacy, Shahid 
      Beheshti University of Medical Sciences, Tehran, Iran.
FAU - Shakoori, Attaollah
AU  - Shakoori A
AD  - Vice-Chancellor for Food and Drugs Affairs, Shahid Beheshti University of Medical 
      Sciences, Tehran, Iran.
FAU - Moradi, Vahideh
AU  - Moradi V
AD  - Vice-Chancellor for Food and Drugs Affairs, Shahid Beheshti University of Medical 
      Sciences, Tehran, Iran.
FAU - Salamzadeh, Jamshid
AU  - Salamzadeh J
AD  - Food Safety Research Center, Shahid Beheshti University of Medical Sciences, 
      Tehran, Iran.
FAU - Mahboubi, Arash
AU  - Mahboubi A
AD  - Department of Pharmaceutics, School of Pharmacy, Shahid Beheshti University of 
      Medical Sciences, Tehran, Iran.
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Iran J Pharm Res
JT  - Iranian journal of pharmaceutical research : IJPR
JID - 101208407
PMC - PMC8457723
OTO - NOTNLM
OT  - GC-MS
OT  - Iran
OT  - Poly Aromatic Hydrocarbons (PAHs)
OT  - Sangak bread
EDAT- 2021/09/28 06:00
MHDA- 2021/09/28 06:01
PMCR- 2021/03/01
CRDT- 2021/09/27 06:05
PHST- 2021/09/27 06:05 [entrez]
PHST- 2021/09/28 06:00 [pubmed]
PHST- 2021/09/28 06:01 [medline]
PHST- 2021/03/01 00:00 [pmc-release]
AID - 10.22037/ijpr.2020.113074.14097 [doi]
PST - ppublish
SO  - Iran J Pharm Res. 2021 Spring;20(2):433-440. doi: 
      10.22037/ijpr.2020.113074.14097.