PMID- 34567510
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210929
IS  - 2090-8067 (Print)
IS  - 2042-0072 (Electronic)
VI  - 2021
DP  - 2021
TI  - Association of Polygenetic Risk Scores Related to Immunity and Inflammation with 
      Hyperthyroidism Risk and Interactions between the Polygenetic Scores and Dietary 
      Factors in a Large Cohort.
PG  - 7664641
LID - 10.1155/2021/7664641 [doi]
LID - 7664641
AB  - Graves's disease and thyroiditis induce hyperthyroidism, the causes of which 
      remain unclear, although they are involved with genetic and environmental 
      factors. We aimed to evaluate polygenetic variants for hyperthyroidism risk and 
      their interaction with metabolic parameters and nutritional intakes in an urban 
      hospital-based cohort. A genome-wide association study (GWAS) of participants 
      with (cases; n = 842) and without (controls, n = 38,799) hyperthyroidism was used 
      to identify and select genetic variants. In clinical and lifestyle interaction 
      with PRS, 312 participants cured of hyperthyroidism were excluded. Single 
      nucleotide polymorphisms (SNPs) associated with gene-gene interactions were 
      selected by hyperthyroidism generalized multifactor dimensionality reduction. 
      Polygenic risk scores (PRSs) were generated by summing the numbers of selected 
      SNP risk alleles. The best gene-gene interaction model included tumor-necrosis 
      factor (TNF)_rs1800610, mucin 22 (MUC22)_rs1304322089, tribbles pseudokinase 2 
      (TRIB2)_rs1881145, cytotoxic T-lymphocyte-associated antigen 4 (CTLA4)_rs231775, 
      lipoma-preferred partner (LPP)_rs6780858, and human leukocyte antigen (HLA)-J_ 
      rs767861647. The PRS of the best model was positively associated with 
      hyperthyroidism risk by 1.939-fold (1.317-2.854) after adjusting for covariates. 
      PRSs interacted with age, metabolic syndrome, and dietary inflammatory index 
      (DII), while hyperthyroidism risk interacted with energy, calcium, seaweed, milk, 
      and coffee intake (P < 0.05). The PRS impact on hyperthyroidism risk was observed 
      in younger (<55 years) participants and adults without metabolic syndrome. PRSs 
      were positively associated with hyperthyroidism risk in participants with low 
      dietary intakes of energy (OR = 2.74), calcium (OR = 2.84), seaweed (OR = 3.43), 
      milk (OR = 2.91), coffee (OR = 2.44), and DII (OR = 3.45). In conclusion, adults 
      with high PRS involved in inflammation and immunity had a high hyperthyroidism 
      risk exacerbated under low intakes of energy, calcium, seaweed, milk, or coffee. 
      These results can be applied to personalized nutrition in a clinical setting.
CI  - Copyright (c) 2021 Mi Young Song and Sunmin Park.
FAU - Song, Mi Young
AU  - Song MY
AD  - School of Food Science and Nutrition, Woo Song University, Daejeon, Republic of 
      Korea.
FAU - Park, Sunmin
AU  - Park S
AUID- ORCID: 0000-0002-6092-8340
AD  - Department of Food and Nutrition, Obesity/Diabetes Research Center, Hoseo 
      University, Asan 31499, Republic of Korea.
AD  - Department of Bio-Convergence System, Hoseo University, Asan 31499, Republic of 
      Korea.
AD  - R&D, Yejun Bio, 165 Sechul-Ri, Baebang-Yup, Asan 31499, Republic of Korea.
LA  - eng
PT  - Journal Article
DEP - 20210914
PL  - United States
TA  - J Thyroid Res
JT  - Journal of thyroid research
JID - 101536655
PMC - PMC8457978
COIS- The authors declare no conflicts of interest.
EDAT- 2021/09/28 06:00
MHDA- 2021/09/28 06:01
PMCR- 2021/09/14
CRDT- 2021/09/27 06:09
PHST- 2021/06/08 00:00 [received]
PHST- 2021/08/14 00:00 [accepted]
PHST- 2021/09/27 06:09 [entrez]
PHST- 2021/09/28 06:00 [pubmed]
PHST- 2021/09/28 06:01 [medline]
PHST- 2021/09/14 00:00 [pmc-release]
AID - 10.1155/2021/7664641 [doi]
PST - epublish
SO  - J Thyroid Res. 2021 Sep 14;2021:7664641. doi: 10.1155/2021/7664641. eCollection 
      2021.