PMID- 34567891
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20210929
IS  - 2168-8184 (Print)
IS  - 2168-8184 (Electronic)
IS  - 2168-8184 (Linking)
VI  - 13
IP  - 8
DP  - 2021 Aug
TI  - Concurrent Urinary Bladder Paraganglioma and Adrenal Phaeochromocytoma With 
      Succinate Dehydrogenase-B Mutation.
PG  - e17350
LID - 10.7759/cureus.17350 [doi]
LID - e17350
AB  - Phaeochromocytoma (PHEO) is a neoplasm that arises from chromaffin cells present 
      in the adrenal medulla. The counterpart of the PHEO extra-adrenal is termed 
      paraganglioma (PGL). The urinary bladder PGL is a rare tumour, and it accounts 
      for less than 0.06% of all bladder tumours. In this report, we discuss a case of 
      a young female who presented with symptoms of headache, dizziness, palpitations, 
      and high blood pressure. After workup, she was diagnosed with concurrent urinary 
      bladder PGL and adrenal PHEO, and the genetic study of the whole exon sequence 
      indicated the presence of succinate dehydrogenase-B (SDHB) mutation. Both tumours 
      were treated surgically; however, the patient ultimately developed recurrence, 
      rapid progression, and metastasis. All secondary modalities were unsuccessful, 
      and the patient was referred for palliative treatment and eventually lost to 
      follow-up. PGL should be included in the differential diagnosis of bladder 
      tumours, and testing for SDHB gene mutations should be considered in all urinary 
      PGLs. Therefore, these patients need follow-up and genetic counselling.
CI  - Copyright (c) 2021, Hafiz et al.
FAU - Hafiz, Bayan
AU  - Hafiz B
AD  - Department of Anatomic Pathology, King Abdulaziz Medical City, Jeddah, SAU.
FAU - Buksh, Omar
AU  - Buksh O
AD  - Department of Urology, King Faisal Specialist Hospital and Research Centre, 
      Jeddah, SAU.
FAU - Alammari, Adel
AU  - Alammari A
AD  - Department of Urology, King Faisal Specialist Hospital and Research Centre, 
      Jeddah, SAU.
FAU - Khogeer, Ahmed
AU  - Khogeer A
AD  - Department of Urology, King Faisal Specialist Hospital and Research Centre, 
      Jeddah, SAU.
FAU - Alturkistani, Samirah
AU  - Alturkistani S
AD  - Department of Radiology, King Faisal Specialist Hospital and Research Centre, 
      Jeddah, SAU.
FAU - Gomaa, Wafaey
AU  - Gomaa W
AD  - Department of Pathology, Faculty of Medicine - King Abdulaziz University, Jeddah, 
      SAU.
AD  - Department of Pathology, Faculty of Medicine - Minia University, Al Minia, EGY.
FAU - Al-Maghrabi, Jaudah
AU  - Al-Maghrabi J
AD  - Department of Pathology, Faculty of Medicine - King Abdulaziz University, Jeddah, 
      SAU.
LA  - eng
PT  - Case Reports
DEP - 20210821
PL  - United States
TA  - Cureus
JT  - Cureus
JID - 101596737
PMC - PMC8451535
OTO - NOTNLM
OT  - adrenal
OT  - bladder
OT  - paraganglioma
OT  - phaeochromocytoma
OT  - sdhb deficiency
COIS- The authors have declared that no competing interests exist.
EDAT- 2021/09/28 06:00
MHDA- 2021/09/28 06:01
PMCR- 2021/08/21
CRDT- 2021/09/27 06:13
PHST- 2021/08/21 00:00 [accepted]
PHST- 2021/09/27 06:13 [entrez]
PHST- 2021/09/28 06:00 [pubmed]
PHST- 2021/09/28 06:01 [medline]
PHST- 2021/08/21 00:00 [pmc-release]
AID - 10.7759/cureus.17350 [doi]
PST - epublish
SO  - Cureus. 2021 Aug 21;13(8):e17350. doi: 10.7759/cureus.17350. eCollection 2021 
      Aug.