PMID- 34568932
OWN - NLM
STAT- MEDLINE
DCOM- 20211022
LR  - 20240426
IS  - 2160-1836 (Electronic)
IS  - 2160-1836 (Linking)
VI  - 11
IP  - 10
DP  - 2021 Sep 27
TI  - Involvement of RNA granule proteins in meiotic silencing by unpaired DNA.
LID - 10.1093/g3journal/jkab179 [doi]
LID - jkab179
AB  - In Neurospora crassa, expression from an unpaired gene is suppressed by a 
      mechanism known as meiotic silencing by unpaired DNA (MSUD). MSUD utilizes common 
      RNA interference (RNAi) factors to silence target mRNAs. Here, we report that 
      Neurospora CAR-1 and CGH-1, homologs of two Caenorhabditis elegans RNA granule 
      components, are involved in MSUD. These fungal proteins are found in the 
      perinuclear region and P-bodies, much like their worm counterparts. They interact 
      with components of the meiotic silencing complex (MSC), including the SMS-2 
      Argonaute. This is the first time MSUD has been linked to RNA granule proteins.
CI  - (c) The Author(s) 2021. Published by Oxford University Press on behalf of Genetics 
      Society of America.
FAU - Xiao, Hua
AU  - Xiao H
AD  - Division of Biological Sciences, University of Missouri, Columbia, MO 65211, USA.
FAU - Vierling, Michael M
AU  - Vierling MM
AD  - Division of Biological Sciences, University of Missouri, Columbia, MO 65211, USA.
FAU - Kennedy, Rana F
AU  - Kennedy RF
AD  - Division of Biological Sciences, University of Missouri, Columbia, MO 65211, USA.
FAU - Boone, Erin C
AU  - Boone EC
AD  - Division of Biological Sciences, University of Missouri, Columbia, MO 65211, USA.
FAU - Decker, Logan M
AU  - Decker LM
AD  - Division of Biological Sciences, University of Missouri, Columbia, MO 65211, USA.
FAU - Sy, Victor T
AU  - Sy VT
AD  - Division of Biological Sciences, University of Missouri, Columbia, MO 65211, USA.
FAU - Haynes, Jackson B
AU  - Haynes JB
AD  - Division of Biological Sciences, University of Missouri, Columbia, MO 65211, USA.
FAU - Williams, Michelle A
AU  - Williams MA
AD  - Division of Biological Sciences, University of Missouri, Columbia, MO 65211, USA.
FAU - Shiu, Patrick K T
AU  - Shiu PKT
AD  - Division of Biological Sciences, University of Missouri, Columbia, MO 65211, USA.
LA  - eng
GR  - P01 GM068087/GM/NIGMS NIH HHS/United States
GR  - T32 GM008396/GM/NIGMS NIH HHS/United States
PT  - Journal Article
PL  - England
TA  - G3 (Bethesda)
JT  - G3 (Bethesda, Md.)
JID - 101566598
RN  - 0 (DNA, Fungal)
RN  - 63231-63-0 (RNA)
SB  - IM
EIN - G3 (Bethesda). 2021 Dec 8;11(12):. PMID: 34849834
MH  - DNA, Fungal
MH  - *Gene Silencing
MH  - Meiosis
MH  - *Neurospora crassa/genetics
MH  - RNA
MH  - RNA Interference
PMC - PMC8482848
OTO - NOTNLM
OT  - Neurospora crassa
OT  - P-bodies
OT  - RNA granules
OT  - RNA interference (RNAi)
OT  - meiotic silencing by unpaired DNA (MSUD)
COIS- None declared.
EDAT- 2021/09/28 06:00
MHDA- 2021/12/02 06:00
PMCR- 2021/05/13
CRDT- 2021/09/27 06:26
PHST- 2021/05/13 00:00 [accepted]
PHST- 2021/02/08 00:00 [received]
PHST- 2021/09/27 06:26 [entrez]
PHST- 2021/09/28 06:00 [pubmed]
PHST- 2021/12/02 06:00 [medline]
PHST- 2021/05/13 00:00 [pmc-release]
AID - 6350059 [pii]
AID - jkab179 [pii]
AID - 10.1093/g3journal/jkab179 [doi]
PST - ppublish
SO  - G3 (Bethesda). 2021 Sep 27;11(10):jkab179. doi: 10.1093/g3journal/jkab179.