PMID- 34568958
OWN - NLM
STAT- MEDLINE
DCOM- 20220215
LR  - 20230502
IS  - 1432-5233 (Electronic)
IS  - 0940-5429 (Print)
IS  - 0940-5429 (Linking)
VI  - 59
IP  - 2
DP  - 2022 Feb
TI  - Contribution of peripheral neuropathy to poor bone health in the feet of people 
      with type 2 diabetes mellitus.
PG  - 217-224
LID - 10.1007/s00592-021-01803-w [doi]
AB  - AIMS: To evaluate the impact of peripheral neuropathy on bone health in people 
      with type 2 diabetes mellitus (T2DM). METHODS: Participants with T2DM were 
      grouped according to the presence of peripheral neuropathy as assessed by 
      vibration perception threshold (VPT). Recruitment ensured groups were balanced 
      for age, sex and body mass index (BMI). Bone health was measured by calcaneal 
      quantitative ultrasound (QUS) and compared between groups. Calcaneal QUS 
      parameters were correlated across the cohort with VPT and other prespecified 
      variables. RESULTS: Thirty-four participants (17 per group) were included with 
      mean age 68 +/- 12 years, 47% male, with median BMI 29.9 (IQR 26.9-32.7) kg/m(2). 
      The peripheral neuropathy group had significantly lower mean Stiffness Index 
      (87 +/- 12 versus 101 +/- 16, p = 0.01), Speed of Sound (1542 +/- 28 versus 
      1574 +/- 34 m/s, p < 0.01), and a trend towards lower Broadband Ultrasound 
      Attenuation (113 +/- 10 versus 120 +/- 12 dB/MHz, p = 0.07). Pedal bone health 
      asymmetry was not a significant feature in those with peripheral neuropathy. All 
      calcaneal QUS parameters correlated negatively with VPT, although significance of 
      the relationship with Broadband Ultrasound Attenuation was nullified if 
      controlled for diabetes duration or time on insulin. Broadband Ultrasound 
      Attenuation showed independent negative correlation with diabetes duration. 
      CONCLUSIONS: People with T2DM and peripheral neuropathy have poorer bone health 
      as measured by calcaneal QUS than those without peripheral neuropathy, 
      independent of age, sex and BMI.
CI  - (c) 2021. Springer-Verlag Italia S.r.l., part of Springer Nature.
FAU - Lasschuit, Joel Willem Johan
AU  - Lasschuit JWJ
AUID- ORCID: 0000-0002-8954-1086
AD  - Department of Endocrinology and Diabetes, St Vincent's Hospital, Sydney, NSW, 
      Australia. j.lasschuit@garvan.org.au.
AD  - Healthy Ageing, Garvan Institute of Medical Research, Sydney, NSW, Australia. 
      j.lasschuit@garvan.org.au.
AD  - Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia. 
      j.lasschuit@garvan.org.au.
FAU - Greenfield, Jerry Richard
AU  - Greenfield JR
AD  - Department of Endocrinology and Diabetes, St Vincent's Hospital, Sydney, NSW, 
      Australia.
AD  - Healthy Ageing, Garvan Institute of Medical Research, Sydney, NSW, Australia.
AD  - Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia.
FAU - Tonks, Katherine Thuy Trang
AU  - Tonks KTT
AD  - Department of Endocrinology and Diabetes, St Vincent's Hospital, Sydney, NSW, 
      Australia.
AD  - Healthy Ageing, Garvan Institute of Medical Research, Sydney, NSW, Australia.
AD  - Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia.
AD  - School of Medicine, University of Notre Dame, Sydney, NSW, Australia.
LA  - eng
PT  - Journal Article
DEP - 20210926
PL  - Germany
TA  - Acta Diabetol
JT  - Acta diabetologica
JID - 9200299
SB  - IM
CIN - Acta Diabetol. 2023 May;60(5):711-712. PMID: 36740652
CIN - Acta Diabetol. 2023 Jul;60(7):999-1000. PMID: 37119304
MH  - Aged
MH  - Aged, 80 and over
MH  - Bone Density
MH  - *Calcaneus/diagnostic imaging
MH  - *Diabetes Mellitus, Type 2/complications
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - *Peripheral Nervous System Diseases/epidemiology/etiology
MH  - Ultrasonography
PMC - PMC8475816
OTO - NOTNLM
OT  - Bone density
OT  - Bone health
OT  - Calcaneal quantitative ultrasound
OT  - Fracture
OT  - Peripheral neuropathy
OT  - Type 2 diabetes mellitus
COIS- The authors declare that they have no conflict of interest.
EDAT- 2021/09/28 06:00
MHDA- 2022/02/16 06:00
PMCR- 2021/09/27
CRDT- 2021/09/27 06:28
PHST- 2021/06/22 00:00 [received]
PHST- 2021/09/13 00:00 [accepted]
PHST- 2021/09/28 06:00 [pubmed]
PHST- 2022/02/16 06:00 [medline]
PHST- 2021/09/27 06:28 [entrez]
PHST- 2021/09/27 00:00 [pmc-release]
AID - 10.1007/s00592-021-01803-w [pii]
AID - 1803 [pii]
AID - 10.1007/s00592-021-01803-w [doi]
PST - ppublish
SO  - Acta Diabetol. 2022 Feb;59(2):217-224. doi: 10.1007/s00592-021-01803-w. Epub 2021 
      Sep 26.