PMID- 34569602
OWN - NLM
STAT- MEDLINE
DCOM- 20220415
LR  - 20220928
IS  - 1758-535X (Electronic)
IS  - 1079-5006 (Print)
IS  - 1079-5006 (Linking)
VI  - 77
IP  - 1
DP  - 2022 Jan 7
TI  - Intrinsic Capacity Predicts Negative Health Outcomes in Older Adults.
PG  - 101-105
LID - 10.1093/gerona/glab279 [doi]
AB  - BACKGROUND: Monitoring trajectories of intrinsic capacity (IC) in older adults 
      has been suggested by the World Health Organization as a means to inform 
      prevention to avoid or delay negative health outcomes. Due to a lack of 
      longitudinal studies, it is currently unclear how IC changes over time and 
      whether repeatedly measured IC predicts negative health outcomes. METHODS: Based 
      on 4 751 repeated observations of IC (range = 0-100) during 21 years of follow-up 
      among 754 older adults 70 and older, we assessed longitudinal trajectories of IC, 
      and whether time-varying IC predicted the risk of chronic activities of daily 
      living disability, long-term nursing home stay, and mortality using joint models. 
      RESULTS: Average IC declined progressively from 77 to 11 points during follow-up, 
      with substantial heterogeneity between older adults. Adjusted for 
      sociodemographics and chronic diseases, a 1-point lower IC value was associated 
      with a 7% increase in the risk of activities of daily living disability, a 6% 
      increase in the risk of a nursing home stay, and a 5% increase in mortality. 
      Accuracy for 5- and 10-year predictions based on up to 3 repeated measurements of 
      IC ranged between moderate and good (area under the receiver operating 
      characteristic curve = 0.76-0.82). CONCLUSIONS: Our study indicates that IC 
      declines progressively and that it predicts negative health outcomes among older 
      adults. Therefore, regular monitoring of IC could work as an early warning system 
      informing preventive efforts.
CI  - (c) The Author(s) 2021. Published by Oxford University Press on behalf of The 
      Gerontological Society of America. All rights reserved. For permissions, please 
      e-mail: journals.permissions@oup.com.
FAU - Stolz, Erwin
AU  - Stolz E
AUID- ORCID: 0000-0001-7393-1568
AD  - Institute of Social Medicine and Epidemiology, Medical University of Graz, 
      Austria.
FAU - Mayerl, Hannes
AU  - Mayerl H
AD  - Institute of Social Medicine and Epidemiology, Medical University of Graz, 
      Austria.
FAU - Freidl, Wolfgang
AU  - Freidl W
AD  - Institute of Social Medicine and Epidemiology, Medical University of Graz, 
      Austria.
FAU - Roller-Wirnsberger, Regina
AU  - Roller-Wirnsberger R
AD  - Department of Internal Medicine, Medical University of Graz, Austria.
FAU - Gill, Thomas M
AU  - Gill TM
AUID- ORCID: 0000-0002-6450-0368
AD  - Department of Internal Medicine, Yale School of Medicine, New Haven, Connecticut, 
      USA.
LA  - eng
GR  - P30AG021342/NH/NIH HHS/United States
GR  - UL1 TR001863/TR/NCATS NIH HHS/United States
GR  - P30 AG021342/AG/NIA NIH HHS/United States
GR  - R01 AG017560/AG/NIA NIH HHS/United States
GR  - R01AG17560/AG/NIA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PL  - United States
TA  - J Gerontol A Biol Sci Med Sci
JT  - The journals of gerontology. Series A, Biological sciences and medical sciences
JID - 9502837
SB  - IM
MH  - *Activities of Daily Living
MH  - Aged
MH  - *Disabled Persons
MH  - Humans
MH  - Longitudinal Studies
MH  - Outcome Assessment, Health Care
PMC - PMC8751795
OTO - NOTNLM
OT  - Epidemiology
OT  - Longitudinal
OT  - Normative aging
OT  - Successful aging
EDAT- 2021/09/28 06:00
MHDA- 2022/04/16 06:00
PMCR- 2022/09/27
CRDT- 2021/09/27 08:59
PHST- 2021/05/26 00:00 [received]
PHST- 2021/09/28 06:00 [pubmed]
PHST- 2022/04/16 06:00 [medline]
PHST- 2021/09/27 08:59 [entrez]
PHST- 2022/09/27 00:00 [pmc-release]
AID - 6375807 [pii]
AID - glab279 [pii]
AID - 10.1093/gerona/glab279 [doi]
PST - ppublish
SO  - J Gerontol A Biol Sci Med Sci. 2022 Jan 7;77(1):101-105. doi: 
      10.1093/gerona/glab279.