PMID- 34569950
OWN - NLM
STAT- MEDLINE
DCOM- 20220104
LR  - 20240404
IS  - 1875-8908 (Electronic)
IS  - 1387-2877 (Print)
IS  - 1387-2877 (Linking)
VI  - 84
IP  - 1
DP  - 2021
TI  - Investigating Auditory Electrophysiological Measures of Participants with Mild 
      Cognitive Impairment and Alzheimer's Disease: A Systematic Review and 
      Meta-Analysis of Event-Related Potential Studies.
PG  - 419-448
LID - 10.3233/JAD-210556 [doi]
AB  - BACKGROUND: Objectively measuring auditory functions has been proposed as an 
      avenue in differentiating normal age-related cognitive dysfunction from 
      Alzheimer's disease (AD) and its prodromal states. Previous research has 
      suggested auditory event-related potentials (AERPs) to be non-invasive, 
      cost-effective, and efficient biomarkers for the diagnosis of AD. OBJECTIVE: The 
      objective of this paper is to review the published literature on AERPs measures 
      in older adults diagnosed with AD and those at higher risk of developing AD, 
      i.e., mild cognitive impairment (MCI) and subjective cognitive decline. METHODS: 
      The search was performed on six major electronic databases (Ovid MEDLINE, OVID 
      EMBASE, PsycINFO, PubMed, Scopus, and CINAHL Plus). Articles identified prior to 
      7 May 2019 were considered for this review. A random effects meta-analysis and 
      analysis of between study heterogeneity was conducted using the Comprehensive 
      Meta-Analysis software. RESULTS: The search identified 1,076 articles; 74 
      articles met the full inclusion criteria and were included in the systematic 
      review, and 47 articles were included into the analyses. Pooled analysis suggests 
      that AD participants can be differentiated from controls due to significant 
      delays in ABR, N100, P200, N200, and P300 latencies. P300 amplitude was 
      significantly smaller in AD participants compared to controls. P300 latencies 
      differed significantly between MCI participants and controls based on the pooled 
      analysis. CONCLUSION: The findings of this review indicate that some AERPs may be 
      valuable biomarkers of AD. In conjunction with currently available clinical and 
      neuropsychological assessments, AERPs can aid in screening and diagnosis of 
      prodromal AD.
FAU - Tarawneh, Hadeel Y
AU  - Tarawneh HY
AD  - School of Human Sciences, The University of Western Australia, Crawley, WA, 
      Australia.
AD  - Ear Science Institute Australia, Subiaco, WA, Australia.
FAU - Mulders, Wilhelmina H A M
AU  - Mulders WHAM
AD  - School of Human Sciences, The University of Western Australia, Crawley, WA, 
      Australia.
FAU - Sohrabi, Hamid R
AU  - Sohrabi HR
AD  - Centre for Healthy Ageing, College of Science, Health, Engineering and Education, 
      Murdoch University, WA, Australia.
AD  - School of Medical and Health Sciences, Edith Cowan University, Joondalup, WA, 
      Australia.
AD  - Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, 
      Macquarie University, Sydney, NSW, Australia.
FAU - Martins, Ralph N
AU  - Martins RN
AD  - School of Medical and Health Sciences, Edith Cowan University, Joondalup, WA, 
      Australia.
AD  - Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, 
      Macquarie University, Sydney, NSW, Australia.
FAU - Jayakody, Dona M P
AU  - Jayakody DMP
AD  - Ear Science Institute Australia, Subiaco, WA, Australia.
AD  - Ear Science Centre, School of Surgery, The University of Western Australia, 
      Crawley, WA, Australia.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Systematic Review
PL  - Netherlands
TA  - J Alzheimers Dis
JT  - Journal of Alzheimer's disease : JAD
JID - 9814863
SB  - IM
MH  - Alzheimer Disease/*diagnosis/physiopathology
MH  - Brain/physiopathology
MH  - Cognitive Dysfunction/*diagnosis
MH  - *Electroencephalography
MH  - Event-Related Potentials, P300
MH  - *Evoked Potentials, Auditory
MH  - Humans
MH  - Infant
MH  - *Prodromal Symptoms
PMC - PMC8609695
OTO - NOTNLM
OT  - Alzheimer's disease
OT  - cognitive function
OT  - event-related potentials
OT  - meta-analysis
OT  - mild cognitive impairment
COIS- Authors' disclosures available online 
      (https://www.j-alz.com/manuscript-disclosures/21-0556r1).
EDAT- 2021/09/28 06:00
MHDA- 2022/01/05 06:00
PMCR- 2021/11/23
CRDT- 2021/09/27 12:20
PHST- 2021/09/28 06:00 [pubmed]
PHST- 2022/01/05 06:00 [medline]
PHST- 2021/09/27 12:20 [entrez]
PHST- 2021/11/23 00:00 [pmc-release]
AID - JAD210556 [pii]
AID - 10.3233/JAD-210556 [doi]
PST - ppublish
SO  - J Alzheimers Dis. 2021;84(1):419-448. doi: 10.3233/JAD-210556.