PMID- 34571043
OWN - NLM
STAT- MEDLINE
DCOM- 20220503
LR  - 20220613
IS  - 1538-9375 (Electronic)
IS  - 1525-8610 (Linking)
VI  - 23
IP  - 5
DP  - 2022 May
TI  - Associations Between Intrinsic Capacity and Adverse Events Among Nursing Home 
      Residents: The INCUR Study.
PG  - 872-876.e4
LID - S1525-8610(21)00775-1 [pii]
LID - 10.1016/j.jamda.2021.08.035 [doi]
AB  - OBJECTIVES: The predictive ability of the novel intrinsic capacity (IC) construct 
      has been scarcely investigated in the nursing home setting. The objective of this 
      study was to investigate the associations of IC and its individual domains with 
      mortality, hospitalization, pneumonia onset, and functional status decline in a 
      population of nursing home residents (NHRs). DESIGN: We undertook an analysis 
      using data from the INCUR study, a prospective observational study. Data were 
      collected at baseline, at 6 and 12 months by trained staff. SETTING AND 
      PARTICIPANTS: A total of 371 NHRs (mean age 85.91 +/- 7.34) dwelling in Southern 
      France. METHODS: A baseline IC composite score was constructed from scores in the 
      Short Physical Performance Battery, Abbreviated Mental Test, 10-item Geriatric 
      Depression Scale, The Short Form of the Mini-Nutritional Assessment, and 
      self-reported hearing and vision impairments. Adverse outcomes were registered by 
      medical records checking. Functional status evolution was evaluated through 
      changes in the Katz Index. Cox regression was used for associations between IC 
      and its domains and adverse outcomes. Linear mixed models were used in the case 
      of functional status evolution. RESULTS: Our analysis revealed associations 
      between a composite score of IC and death [hazard ratio 0.33; 95% confidence 
      interval (CI) 0.15-0.73] and functional status evolution (beta = 0.14; 95% CI 
      0.018-0.29) in our population. Although greater values in IC vitality/nutrition 
      domain were associated with survival (HR 0.84; 95% CI 0.70-0.99), IC cognitive 
      domain was associated with decreased odds of hospitalization (HR 0.91; 95% CI 
      0.84-0.99) and lower declines in functional status (beta = 0.04; 95% CI 0.01-0.07), 
      whereas the IC locomotion domain was inversely associated with pneumonia 
      incidence (HR 0.84; 95% CI 0.72-0.98). CONCLUSIONS AND IMPLICATIONS: Our results 
      contribute to preliminary evidence linking greater IC levels and lower risk of 
      late-life adverse outcomes.
CI  - Copyright (c) 2021 AMDA - The Society for Post-Acute and Long-Term Care Medicine. 
      Published by Elsevier Inc. All rights reserved.
FAU - Sanchez-Sanchez, Juan Luis
AU  - Sanchez-Sanchez JL
AD  - Gerontopole of Toulouse, Institute of Ageing, Toulouse University Hospital (CHU 
      Toulouse), Toulouse, France. Electronic address: jl.sanchezs@hotmail.com.
FAU - Rolland, Yves
AU  - Rolland Y
AD  - Gerontopole of Toulouse, Institute of Ageing, Toulouse University Hospital (CHU 
      Toulouse), Toulouse, France; CERPOP UMR1295, Universite de Toulouse, Inserm, UPS, 
      Toulouse, France.
FAU - Cesari, Matteo
AU  - Cesari M
AD  - IRCCS Istituti Clinici Scientifici Maugeri, University of Milan, Milan, Italy.
FAU - de Souto Barreto, Philipe
AU  - de Souto Barreto P
AD  - Gerontopole of Toulouse, Institute of Ageing, Toulouse University Hospital (CHU 
      Toulouse), Toulouse, France; CERPOP UMR1295, Universite de Toulouse, Inserm, UPS, 
      Toulouse, France.
LA  - eng
PT  - Journal Article
PT  - Observational Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20210925
PL  - United States
TA  - J Am Med Dir Assoc
JT  - Journal of the American Medical Directors Association
JID - 100893243
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - France/epidemiology
MH  - *Geriatric Assessment/methods
MH  - Humans
MH  - Nursing Homes
MH  - Nutrition Assessment
MH  - *Pneumonia/epidemiology
OTO - NOTNLM
OT  - Intrinsic capacity
OT  - adverse outcomes
OT  - long-term care
OT  - nursing home
OT  - pneumonia
EDAT- 2021/09/28 06:00
MHDA- 2022/05/04 06:00
CRDT- 2021/09/27 20:12
PHST- 2021/04/05 00:00 [received]
PHST- 2021/08/09 00:00 [revised]
PHST- 2021/08/23 00:00 [accepted]
PHST- 2021/09/28 06:00 [pubmed]
PHST- 2022/05/04 06:00 [medline]
PHST- 2021/09/27 20:12 [entrez]
AID - S1525-8610(21)00775-1 [pii]
AID - 10.1016/j.jamda.2021.08.035 [doi]
PST - ppublish
SO  - J Am Med Dir Assoc. 2022 May;23(5):872-876.e4. doi: 10.1016/j.jamda.2021.08.035. 
      Epub 2021 Sep 25.