PMID- 34571181
OWN - NLM
STAT- MEDLINE
DCOM- 20220310
LR  - 20230807
IS  - 1526-3231 (Electronic)
IS  - 0749-8063 (Linking)
VI  - 38
IP  - 2
DP  - 2022 Feb
TI  - Intra-articular Pure Platelet-Rich Plasma Combined With Open-Wedge High Tibial 
      Osteotomy Improves Clinical Outcomes and Minimal Joint Space Width Compared With 
      High Tibial Osteotomy Alone in Knee Osteoarthritis: A Prospective Study.
PG  - 476-485
LID - S0749-8063(21)00845-8 [pii]
LID - 10.1016/j.arthro.2021.09.013 [doi]
AB  - PURPOSE: To compare the clinical efficacy of the patients with medial compartment 
      knee osteoarthritis who underwent either opening-wedge high tibial osteotomy 
      alone (HTO) or simultaneous HTO and pure platelet-rich plasma therapy 
      (HTO+P-PRP). METHODS: Eighty patients were divided into 2 groups randomly, the 
      HTO-alone group (n = 41) and the HTO+P-PRP group (n = 39). Patients were matched 
      for preoperative age, sex, and body mass index. The outcomes studied included 
      visual analogue scale (VAS) score, Western Ontario and McMaster Universities 
      Osteoarthritis Index (WOMAC), and Lysholm score. The minimum width of medial knee 
      joint (MJSW), medial proximal tibial angle (MPTA), femoral tibial angle (FTA), 
      and weightbearing line (WBL) were measured preoperatively, immediately 
      postoperatively, and 1, 6, 12, and 24 months postoperatively. Paired t test and 
      chi-squared test were used for statistical analysis. RESULTS: All patients were 
      followed up at 1, 6, 12, and 24 months postoperatively. At 1, 6, and 12 months, 
      pain and function scores in the HTO+P-PRP group were better than those in the 
      HTO-alone group, especially at 6 months in Lysholm score (HTO alone, 72.5 +/- 10.6; 
      HTO+P-PRP, 83.1 +/- 14.7; P = .003, 95% CI -14.13 to -10.42) and WOMAC (HTO alone, 
      90.3 +/- 11.9; HTO+P-PRP, 75.6 +/- 15.4; P < .001, 95% CI 13.36 to 20.11). For both 
      groups, no difference was found preoperatively (HTO alone, varus 3.5 +/- 3.9; 
      HTO+P-PRP, varus 4.1 +/- 4.0; P = .898) or postoperatively (HTO alone, valgus 6.7 +/- 
      4.5; HTO+P-PRP, valgus 7.7 +/- 2.3; P = .768) in FTA or WBL. The increase of the 
      MJSW in the HTO+P-PRP group was significantly greater than that in the HTO-alone 
      group during the first year, especially at 6 months (HTO alone, 3.8 +/- 1.2 mm; 
      HTO+P-PRP, 4.6 +/- 1.1 mm; P = .001, 95% CI -1.27 to -0.35). CONCLUSIONS: Compared 
      with HTO alone, HTO combined with intra-articular P-PRP improved the minimum 
      medial knee joint space width during the first year postoperatively. Clinically, 
      a higher proportion of patients in the HTO+P-PRP group exceeded the minimal 
      clinically important difference (MCID) in the first year, especially at 6 months 
      in Lysholm score (HTO alone, 65.9%; HTO+P-PRP, 97.4%) and WOMAC (HTO alone, 
      82.9%; HTO+P-PRP, 100.0%). LEVEL OF EVIDENCE: 2, prospective comparative study.
CI  - Copyright (c) 2021 Arthroscopy Association of North America. Published by Elsevier 
      Inc. All rights reserved.
FAU - Zhang, Qian
AU  - Zhang Q
AD  - Department of Orthopedics, The First Affiliated Hospital of Soochow University, 
      Suzhou, Jiangsu, PR China.
FAU - Xu, Wu
AU  - Xu W
AD  - Department of Orthopedics, The First Affiliated Hospital of Soochow University, 
      Suzhou, Jiangsu, PR China.
FAU - Wu, Kailun
AU  - Wu K
AD  - Department of Orthopedics, Dushu Lake Hospital Affiliated to Soochow University, 
      Suzhou, Jiangsu, PR China.
FAU - Fu, Weili
AU  - Fu W
AD  - Department of Orthopedics, West China Hospital, Sichuan University, Chengdu, PR 
      China.
FAU - Yang, Huilin
AU  - Yang H
AD  - Department of Orthopedics, The First Affiliated Hospital of Soochow University, 
      Suzhou, Jiangsu, PR China.
FAU - Guo, Jiong Jiong
AU  - Guo JJ
AD  - Department of Orthopedics, The First Affiliated Hospital of Soochow University, 
      Suzhou, Jiangsu, PR China. Electronic address: guojiongjiong@suda.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20210925
PL  - United States
TA  - Arthroscopy
JT  - Arthroscopy : the journal of arthroscopic & related surgery : official 
      publication of the Arthroscopy Association of North America and the International 
      Arthroscopy Association
JID - 8506498
SB  - IM
CIN - Arthroscopy. 2022 Feb;38(2):486-488. PMID: 35123720
CIN - Arthroscopy. 2023 Sep;39(9):1959-1960. PMID: 37543379
MH  - Humans
MH  - Knee Joint/surgery
MH  - *Osteoarthritis, Knee/surgery
MH  - Osteotomy
MH  - *Platelet-Rich Plasma
MH  - Prospective Studies
MH  - Tibia/surgery
MH  - Treatment Outcome
EDAT- 2021/09/28 06:00
MHDA- 2022/03/11 06:00
CRDT- 2021/09/27 20:14
PHST- 2021/04/28 00:00 [received]
PHST- 2021/09/04 00:00 [revised]
PHST- 2021/09/07 00:00 [accepted]
PHST- 2021/09/28 06:00 [pubmed]
PHST- 2022/03/11 06:00 [medline]
PHST- 2021/09/27 20:14 [entrez]
AID - S0749-8063(21)00845-8 [pii]
AID - 10.1016/j.arthro.2021.09.013 [doi]
PST - ppublish
SO  - Arthroscopy. 2022 Feb;38(2):476-485. doi: 10.1016/j.arthro.2021.09.013. Epub 2021 
      Sep 25.