PMID- 34571848
OWN - NLM
STAT- MEDLINE
DCOM- 20211119
LR  - 20211119
IS  - 2073-4409 (Electronic)
IS  - 2073-4409 (Linking)
VI  - 10
IP  - 9
DP  - 2021 Aug 26
TI  - Extracellular Vehicles of Oxygen-Depleted Mesenchymal Stromal Cells: Route to 
      Off-Shelf Cellular Therapeutics?
LID - 10.3390/cells10092199 [doi]
LID - 2199
AB  - Cellular therapy is a promising tool of human medicine to successfully treat 
      complex and challenging pathologies such as cardiovascular diseases or chronic 
      inflammatory conditions. Bone marrow-derived mesenchymal stromal cells (BMSCs) 
      are in the limelight of these efforts, initially, trying to exploit their natural 
      properties by direct transplantation. Extensive research on the therapeutic use 
      of BMSCs shed light on a number of key aspects of BMSC physiology including the 
      importance of oxygen in the control of BMSC phenotype. These efforts also led to 
      a growing number of evidence indicating that the beneficial therapeutic effects 
      of BMSCs can be mediated by BMSC-secreted agents. Further investigations revealed 
      that BMSC-excreted extracellular vesicles could mediate the potentially 
      therapeutic effects of BMSCs. Here, we review our current understanding of the 
      relationship between low oxygen conditions and the effects of BMSC-secreted 
      extracellular vesicles focusing on the possible medical relevance of this 
      interplay.
FAU - Gala, Dhir
AU  - Gala D
AD  - Department of Molecular Cell Biology, School of Medicine, Faculty of Clinical and 
      Biomedical Sciences, University of Central Lancashire, Preston PR1 1JQ, UK.
FAU - Mohak, Sidhesh
AU  - Mohak S
AD  - Department of Molecular Cell Biology, School of Medicine, Faculty of Clinical and 
      Biomedical Sciences, University of Central Lancashire, Preston PR1 1JQ, UK.
FAU - Fabian, Zsolt
AU  - Fabian Z
AD  - Department of Molecular Cell Biology, School of Medicine, Faculty of Clinical and 
      Biomedical Sciences, University of Central Lancashire, Preston PR1 1JQ, UK.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20210826
PL  - Switzerland
TA  - Cells
JT  - Cells
JID - 101600052
RN  - S88TT14065 (Oxygen)
SB  - IM
MH  - Animals
MH  - Bone Marrow Cells/cytology
MH  - Cell Differentiation/physiology
MH  - Cell Hypoxia/physiology
MH  - Cell- and Tissue-Based Therapy/methods
MH  - Extracellular Vesicles/*metabolism/transplantation
MH  - Humans
MH  - Mesenchymal Stem Cell Transplantation/*methods
MH  - Mesenchymal Stem Cells/*metabolism/physiology
MH  - Oxygen/metabolism
PMC - PMC8465344
OTO - NOTNLM
OT  - bone marrow-derived stromal cells
OT  - extracellular vesicles
OT  - hypoxia
COIS- Authors declare no conflicts of interest.
EDAT- 2021/09/29 06:00
MHDA- 2021/11/20 06:00
PMCR- 2021/08/26
CRDT- 2021/09/28 01:03
PHST- 2021/08/08 00:00 [received]
PHST- 2021/08/23 00:00 [revised]
PHST- 2021/08/24 00:00 [accepted]
PHST- 2021/09/28 01:03 [entrez]
PHST- 2021/09/29 06:00 [pubmed]
PHST- 2021/11/20 06:00 [medline]
PHST- 2021/08/26 00:00 [pmc-release]
AID - cells10092199 [pii]
AID - cells-10-02199 [pii]
AID - 10.3390/cells10092199 [doi]
PST - epublish
SO  - Cells. 2021 Aug 26;10(9):2199. doi: 10.3390/cells10092199.