PMID- 34573117
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20211001
IS  - 2076-3921 (Print)
IS  - 2076-3921 (Electronic)
IS  - 2076-3921 (Linking)
VI  - 10
IP  - 9
DP  - 2021 Sep 17
TI  - Glyoxal-Lysine Dimer, an Advanced Glycation End Product, Induces Oxidative Damage 
      and Inflammatory Response by Interacting with RAGE.
LID - 10.3390/antiox10091486 [doi]
LID - 1486
AB  - The glyoxal-lysine dimer (GOLD), which is a glyoxal (GO)-derived advanced 
      glycation end product (AGE), is produced by the glycation reaction. In this 
      study, we evaluated the effect of GOLD on the oxidative damage and inflammatory 
      response in SV40 MES 13 mesangial cells. GOLD significantly increased the linkage 
      with the V-type immunoglobulin domain of RAGE, a specific receptor of AGE. We 
      found that GOLD treatment increased RAGE expression and reactive oxygen species 
      (ROS) production in mesangial cells. GOLD remarkably regulated the protein and 
      mRNA expression of nuclear factor erythroid 2-related factor 2 (NRF2) and 
      glyoxalase 1 (GLO1). In addition, mitochondrial deterioration and inflammation 
      occurred via GOLD-induced oxidative stress in mesangial cells. GOLD regulated the 
      mitogen-activated protein kinase (MAPK) and the release of proinflammatory 
      cytokines associated with the inflammatory mechanism of mesangial cells. 
      Furthermore, oxidative stress and inflammatory responses triggered by GOLD were 
      suppressed through RAGE inhibition using RAGE siRNA. These results demonstrate 
      that the interaction of GOLD and RAGE plays an important role in the function of 
      mesangial cells.
FAU - Lee, Hee-Weon
AU  - Lee HW
AD  - Korea Food Research Institute, 245, Nongsaengmyeong-ro, Iseo-myeon, Wanju-gun 
      55365, Jeollabuk-do, Korea.
FAU - Gu, Min Ji
AU  - Gu MJ
AD  - Korea Food Research Institute, 245, Nongsaengmyeong-ro, Iseo-myeon, Wanju-gun 
      55365, Jeollabuk-do, Korea.
FAU - Kim, Yoonsook
AU  - Kim Y
AD  - Korea Food Research Institute, 245, Nongsaengmyeong-ro, Iseo-myeon, Wanju-gun 
      55365, Jeollabuk-do, Korea.
FAU - Lee, Jee-Young
AU  - Lee JY
AUID- ORCID: 0000-0003-2418-7220
AD  - Molecular Design Team, New Drug Development Center, Daegu Gyeongbuk Medical 
      Innovation Foundation (DGMIF), Daegu 41061, Korea.
FAU - Lee, Seungju
AU  - Lee S
AUID- ORCID: 0000-0002-6329-9869
AD  - Molecular Design Team, New Drug Development Center, Daegu Gyeongbuk Medical 
      Innovation Foundation (DGMIF), Daegu 41061, Korea.
FAU - Choi, In-Wook
AU  - Choi IW
AD  - Korea Food Research Institute, 245, Nongsaengmyeong-ro, Iseo-myeon, Wanju-gun 
      55365, Jeollabuk-do, Korea.
FAU - Ha, Sang Keun
AU  - Ha SK
AUID- ORCID: 0000-0002-3329-2279
AD  - Korea Food Research Institute, 245, Nongsaengmyeong-ro, Iseo-myeon, Wanju-gun 
      55365, Jeollabuk-do, Korea.
AD  - Division of Food Biotechnology, University of Science and Technology, Daejeon 
      34113, Korea.
LA  - eng
GR  - E 0210203/Korea Food Research Institute/
GR  - NRF-2020R1A2C2012608/National Research Foundation of Korea/
PT  - Journal Article
DEP - 20210917
PL  - Switzerland
TA  - Antioxidants (Basel)
JT  - Antioxidants (Basel, Switzerland)
JID - 101668981
PMC - PMC8470194
OTO - NOTNLM
OT  - NRF2/GLO-1
OT  - advanced glycation end product
OT  - glyoxal-lysine dimer
OT  - mitochondrial function
OT  - oxidative stress
OT  - receptor of advanced glycation end product
COIS- The authors have no conflict of interest to disclose.
EDAT- 2021/09/29 06:00
MHDA- 2021/09/29 06:01
PMCR- 2021/09/17
CRDT- 2021/09/28 01:08
PHST- 2021/08/09 00:00 [received]
PHST- 2021/09/13 00:00 [revised]
PHST- 2021/09/14 00:00 [accepted]
PHST- 2021/09/28 01:08 [entrez]
PHST- 2021/09/29 06:00 [pubmed]
PHST- 2021/09/29 06:01 [medline]
PHST- 2021/09/17 00:00 [pmc-release]
AID - antiox10091486 [pii]
AID - antioxidants-10-01486 [pii]
AID - 10.3390/antiox10091486 [doi]
PST - epublish
SO  - Antioxidants (Basel). 2021 Sep 17;10(9):1486. doi: 10.3390/antiox10091486.