PMID- 34573894
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230921
IS  - 2075-4418 (Print)
IS  - 2075-4418 (Electronic)
IS  - 2075-4418 (Linking)
VI  - 11
IP  - 9
DP  - 2021 Aug 27
TI  - Atopic Dermatitis-Beyond the Skin.
LID - 10.3390/diagnostics11091553 [doi]
LID - 1553
AB  - Atopic dermatitis is a chronic inflammatory disease that can arise during the 
      first months of life or at maturity and have a significant negative impact on the 
      quality of life. The main pathogenic mechanism is the breakdown of cutaneous 
      barrier integrity, which is associated with systemic inflammatory immunologic 
      disorders. Atopic dermatitis involves numerous immunologic, allergic, 
      respiratory, and ophthalmologic comorbidities that develop through similar 
      intricate pathogenic phenomena. The atopic march represents the evolution in time 
      of various allergic diseases, of which food allergies often cause the first 
      manifestations of atopy, even from a very young age. Chronic inflammation 
      translated through specific markers, next to increased immunoglobulin E (IgE) 
      serum levels and heterogenous clinical manifestations, argue for the inclusion of 
      atopic dermatitis in the systemic disease category.
FAU - Mocanu, Madalina
AU  - Mocanu M
AD  - Department of Oral Dermatology, "Grigore T. Popa" University of Medicine and 
      Pharmacy, 700115 Iasi, Romania.
FAU - Vata, Dan
AU  - Vata D
AD  - Department of Dermatology, "Grigore T. Popa" University of Medicine and Pharmacy, 
      700115 Iasi, Romania.
FAU - Alexa, Anisia-Iuliana
AU  - Alexa AI
AD  - Department of Ophthalmology, "Grigore T. Popa" University of Medicine and 
      Pharmacy, 700115 Iasi, Romania.
FAU - Trandafir, Laura
AU  - Trandafir L
AD  - Department of Mother and Child Medicine-Pediatrics, "Grigore T. Popa" University 
      of Medicine and Pharmacy, 700115 Iasi, Romania.
FAU - Patrascu, Adriana-Ionela
AU  - Patrascu AI
AD  - Dermatology Clinic, "St. Spiridon" County Emergency Clinical Hospital, 700111 
      Iasi, Romania.
FAU - Hancu, Madalina Florina
AU  - Hancu MF
AD  - Dermatology Clinic, "St. Spiridon" County Emergency Clinical Hospital, 700111 
      Iasi, Romania.
FAU - Gheuca-Solovastru, Laura
AU  - Gheuca-Solovastru L
AD  - Department of Dermatology, "Grigore T. Popa" University of Medicine and Pharmacy, 
      700115 Iasi, Romania.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20210827
PL  - Switzerland
TA  - Diagnostics (Basel)
JT  - Diagnostics (Basel, Switzerland)
JID - 101658402
PMC - PMC8464732
OTO - NOTNLM
OT  - atopic dermatitis
OT  - chronic inflammation
OT  - comorbidities
OT  - extra-cutaneous manifestations
COIS- The authors declare no conflict of interest.
EDAT- 2021/09/29 06:00
MHDA- 2021/09/29 06:01
PMCR- 2021/08/27
CRDT- 2021/09/28 01:10
PHST- 2021/05/30 00:00 [received]
PHST- 2021/08/24 00:00 [revised]
PHST- 2021/08/25 00:00 [accepted]
PHST- 2021/09/28 01:10 [entrez]
PHST- 2021/09/29 06:00 [pubmed]
PHST- 2021/09/29 06:01 [medline]
PHST- 2021/08/27 00:00 [pmc-release]
AID - diagnostics11091553 [pii]
AID - diagnostics-11-01553 [pii]
AID - 10.3390/diagnostics11091553 [doi]
PST - epublish
SO  - Diagnostics (Basel). 2021 Aug 27;11(9):1553. doi: 10.3390/diagnostics11091553.