PMID- 34574542
OWN - NLM
STAT- MEDLINE
DCOM- 20211101
LR  - 20211101
IS  - 1660-4601 (Electronic)
IS  - 1661-7827 (Print)
IS  - 1660-4601 (Linking)
VI  - 18
IP  - 18
DP  - 2021 Sep 12
TI  - Association between Hypertriglyceridemic-Waist Phenotype and Risk of Type 2 
      Diabetes Mellitus in Middle-Aged and Older Chinese Population: A Longitudinal 
      Cohort Study.
LID - 10.3390/ijerph18189618 [doi]
LID - 9618
AB  - Current evidence remains inconsistent with regard to the association between 
      different triglyceridemic-waist phenotypes and the risks for type 2 diabetes 
      mellitus (T2DM). We aimed to investigate this association among a retrospective 
      cohort analysis of 6918 participants aged >/= 45 years in the China Health and 
      Retirement Longitudinal Study (CHARLS). Participants were categorized into four 
      triglyceridemic-waist phenotypes consisting of NWNT (normal waist circumference 
      and normal triglycerides), NWHT (normal waist circumference and high 
      triglycerides), EWNT (enlarged waist circumference and normal triglycerides), and 
      EWHT (enlarged waist circumference and high triglycerides) based on participants' 
      baseline information. Multivariate log-binomial regression was used to assess the 
      T2DM risk in different phenotypes. Subgroup analysis was conducted to test the 
      robustness of the findings. After 4-years of follow-up, participants with EWHT 
      (Relative Risk [RR]: 1.909, 95% Confidence Interval [CI]: 1.499 to 2.447) or EWNT 
      (RR: 1.580, 95%CI: 1.265 to 1.972) phenotypes had significantly higher likelihood 
      of incident T2DM compared to the NWNT phenotype, whereas the association was not 
      significant for the NWHT phenotype (RR: 1.063, 95%CI: 0.793 to 1.425). The 
      subgroup analyses generally revealed similar associations across all subgroups. 
      Among middle-aged and older adults, we suggested a combined use of waist 
      circumference and triglycerides measures in identifying participants who are at 
      high risk of developing T2DM.
FAU - Chen, Dezhong
AU  - Chen D
AUID- ORCID: 0000-0002-2280-817X
AD  - School of Public Health, Sun Yat-Sen University, 74 Zhongshan Second Road, 
      Guangzhou 510080, China.
FAU - Liang, Ziyun
AU  - Liang Z
AD  - School of Public Health, Sun Yat-Sen University, 74 Zhongshan Second Road, 
      Guangzhou 510080, China.
FAU - Sun, Huimin
AU  - Sun H
AUID- ORCID: 0000-0002-5624-857X
AD  - School of Public Health, Sun Yat-Sen University, 74 Zhongshan Second Road, 
      Guangzhou 510080, China.
FAU - Lu, Ciyong
AU  - Lu C
AD  - School of Public Health, Sun Yat-Sen University, 74 Zhongshan Second Road, 
      Guangzhou 510080, China.
FAU - Chen, Weiqing
AU  - Chen W
AD  - School of Public Health, Sun Yat-Sen University, 74 Zhongshan Second Road, 
      Guangzhou 510080, China.
FAU - Wang, Harry H X
AU  - Wang HHX
AUID- ORCID: 0000-0002-0361-6527
AD  - School of Public Health, Sun Yat-Sen University, 74 Zhongshan Second Road, 
      Guangzhou 510080, China.
FAU - Guo, Vivian Yawei
AU  - Guo VY
AD  - School of Public Health, Sun Yat-Sen University, 74 Zhongshan Second Road, 
      Guangzhou 510080, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20210912
PL  - Switzerland
TA  - Int J Environ Res Public Health
JT  - International journal of environmental research and public health
JID - 101238455
SB  - IM
MH  - Aged
MH  - Body Mass Index
MH  - China/epidemiology
MH  - Cohort Studies
MH  - *Diabetes Mellitus, Type 2/epidemiology
MH  - Humans
MH  - Longitudinal Studies
MH  - Middle Aged
MH  - Phenotype
MH  - Retrospective Studies
MH  - Risk Factors
MH  - Waist Circumference
PMC - PMC8466002
OTO - NOTNLM
OT  - Chinese adults
OT  - central obesity
OT  - hypertriglyceridemia
OT  - type 2 diabetes mellitus
COIS- The authors declared no conflict of interest.
EDAT- 2021/09/29 06:00
MHDA- 2021/11/03 06:00
PMCR- 2021/09/12
CRDT- 2021/09/28 01:12
PHST- 2021/06/22 00:00 [received]
PHST- 2021/08/27 00:00 [revised]
PHST- 2021/09/07 00:00 [accepted]
PHST- 2021/09/28 01:12 [entrez]
PHST- 2021/09/29 06:00 [pubmed]
PHST- 2021/11/03 06:00 [medline]
PHST- 2021/09/12 00:00 [pmc-release]
AID - ijerph18189618 [pii]
AID - ijerph-18-09618 [pii]
AID - 10.3390/ijerph18189618 [doi]
PST - epublish
SO  - Int J Environ Res Public Health. 2021 Sep 12;18(18):9618. doi: 
      10.3390/ijerph18189618.