PMID- 34574977 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20211001 IS - 2227-9032 (Print) IS - 2227-9032 (Electronic) IS - 2227-9032 (Linking) VI - 9 IP - 9 DP - 2021 Sep 13 TI - Retrospective Analysis of Clinicopathological Features and Familial Cancer History of Synchronous Bilateral Breast Cancer. LID - 10.3390/healthcare9091203 [doi] LID - 1203 AB - Bilateral breast cancer is a strong predictor of BRCA 1/2 mutation and hence one criterion indicated for hereditary genetic testing. The purpose of this study is to assess the characteristics of synchronous bilateral breast cancer (SBBC) and its association with personal and familial cancer traits. Patients diagnosed with SBBC in our institute between 1992 and 2018 were retrospectively reviewed, and the information of clinicopathological features, personal and family cancer history were analyzed. Of the 307 SBBCs enrolled, the growing case number generally aligned with the regional breast cancer incidence after the era of population-based mammography screening. SBBC patients had similar cancer stages but worse survival outcomes than those in the standard scenario. A total of 42.0% had mixed pathological diagnoses, and 22.8% had discordant immunohistochemistry (IHC) subtypes from both sides, which contributed to treatment challenges. The correlation of SBBC with hereditary breast and ovarian cancer (HBOC) syndrome was strongly implied, as 20.7% of our SBBC patients with known familial cancer histories had HOBC-related familial cancers (breast, ovarian, or prostate cancers). These findings highlight the need for genetic counseling and germline mutation testing in patients with SBBC. Early PARP inhibitor treatment should also be considered in high-risk cases for outcome improvement. FAU - Huang, Kai-Ling AU - Huang KL AUID- ORCID: 0000-0001-8719-2495 AD - Department of Medical Education, Chang Gung Memorial Hospital, Linkou and Taipei Medical Center, Chang Gung Medical Foundation, Taoyuan 33305, Taiwan. AD - Department of Orthopedics, Kaohsiung Veterans General Hospital, Kaohsiung 81362, Taiwan. FAU - Liu, Yu-Ling AU - Liu YL AUID- ORCID: 0000-0002-4877-6479 AD - Breast Surgery Division, General Surgery, Department of Surgery, Chang Gung Memorial Hospital, Linkou and Taipei Medical Center, Chang Gung Medical Foundation, Taipei 33305, Taiwan. FAU - Hsu, Ya-Ying AU - Hsu YY AD - Chang Gung University, Taoyuan 33302, Taiwan. FAU - Kuo, Wen-Ling AU - Kuo WL AUID- ORCID: 0000-0002-1145-8514 AD - Breast Surgery Division, General Surgery, Department of Surgery, Chang Gung Memorial Hospital, Linkou and Taipei Medical Center, Chang Gung Medical Foundation, Taipei 33305, Taiwan. AD - Chang Gung University, Taoyuan 33302, Taiwan. LA - eng GR - CORPG1H0061/Chang Gung Memorial Hospital/ PT - Journal Article DEP - 20210913 PL - Switzerland TA - Healthcare (Basel) JT - Healthcare (Basel, Switzerland) JID - 101666525 PMC - PMC8470905 OTO - NOTNLM OT - bilateral OT - breast cancer OT - cancer gene predisposition OT - genetic counseling OT - germline mutation OT - hereditary breast and ovarian cancer syndrome OT - synchronous COIS- The authors declare no conflict of interest. EDAT- 2021/09/29 06:00 MHDA- 2021/09/29 06:01 PMCR- 2021/09/13 CRDT- 2021/09/28 01:14 PHST- 2021/07/26 00:00 [received] PHST- 2021/08/20 00:00 [revised] PHST- 2021/09/01 00:00 [accepted] PHST- 2021/09/28 01:14 [entrez] PHST- 2021/09/29 06:00 [pubmed] PHST- 2021/09/29 06:01 [medline] PHST- 2021/09/13 00:00 [pmc-release] AID - healthcare9091203 [pii] AID - healthcare-09-01203 [pii] AID - 10.3390/healthcare9091203 [doi] PST - epublish SO - Healthcare (Basel). 2021 Sep 13;9(9):1203. doi: 10.3390/healthcare9091203.