PMID- 34578570
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240403
IS  - 2079-4991 (Print)
IS  - 2079-4991 (Electronic)
IS  - 2079-4991 (Linking)
VI  - 11
IP  - 9
DP  - 2021 Aug 31
TI  - Non-Heating Alternating Magnetic Field Nanomechanical Stimulation of Biomolecule 
      Structures via Magnetic Nanoparticles as the Basis for Future Low-Toxic 
      Biomedical Applications.
LID - 10.3390/nano11092255 [doi]
LID - 2255
AB  - The review discusses the theoretical, experimental and toxicological aspects of 
      the prospective biomedical application of functionalized magnetic nanoparticles 
      (MNPs) activated by a low frequency non-heating alternating magnetic field (AMF). 
      In this approach, known as nano-magnetomechanical activation (NMMA), the MNPs are 
      used as mediators that localize and apply force to such target biomolecular 
      structures as enzyme molecules, transport vesicles, cell organelles, etc., 
      without significant heating. It is shown that NMMA can become a biophysical 
      platform for a family of therapy methods including the addressed delivery and 
      controlled release of therapeutic agents from transport nanomodules, as well as 
      selective molecular nanoscale localized drugless nanomechanical impacts. It is 
      characterized by low system biochemical and electromagnetic toxicity. A technique 
      of 3D scanning of the NMMA region with the size of several mm to several cm over 
      object internals has been described.
FAU - Golovin, Yuri I
AU  - Golovin YI
AD  - Institute "Nanotechnology and Nanomaterials", G.R. Derzhavin Tambov State 
      University, 392000 Tambov, Russia.
AD  - Department of Chemical Enzymology, School of Chemistry, Lomonosov Moscow State 
      University, 119991 Moscow, Russia.
FAU - Golovin, Dmitry Yu
AU  - Golovin DY
AD  - Institute "Nanotechnology and Nanomaterials", G.R. Derzhavin Tambov State 
      University, 392000 Tambov, Russia.
FAU - Vlasova, Ksenia Yu
AU  - Vlasova KY
AD  - Department of Chemical Enzymology, School of Chemistry, Lomonosov Moscow State 
      University, 119991 Moscow, Russia.
FAU - Veselov, Maxim M
AU  - Veselov MM
AD  - Department of Chemical Enzymology, School of Chemistry, Lomonosov Moscow State 
      University, 119991 Moscow, Russia.
FAU - Usvaliev, Azizbek D
AU  - Usvaliev AD
AD  - Department of Chemical Enzymology, School of Chemistry, Lomonosov Moscow State 
      University, 119991 Moscow, Russia.
FAU - Kabanov, Alexander V
AU  - Kabanov AV
AD  - Department of Chemical Enzymology, School of Chemistry, Lomonosov Moscow State 
      University, 119991 Moscow, Russia.
AD  - Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel 
      Hill, NC 27599, USA.
FAU - Klyachko, Natalia L
AU  - Klyachko NL
AUID- ORCID: 0000-0002-9357-8236
AD  - Institute "Nanotechnology and Nanomaterials", G.R. Derzhavin Tambov State 
      University, 392000 Tambov, Russia.
AD  - Department of Chemical Enzymology, School of Chemistry, Lomonosov Moscow State 
      University, 119991 Moscow, Russia.
AD  - Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel 
      Hill, NC 27599, USA.
LA  - eng
GR  - 18-29-09154/Russian Foundation for Fundamental Investigations/
PT  - Journal Article
PT  - Review
DEP - 20210831
PL  - Switzerland
TA  - Nanomaterials (Basel)
JT  - Nanomaterials (Basel, Switzerland)
JID - 101610216
PMC - PMC8470408
OTO - NOTNLM
OT  - apoptosis
OT  - controlled release
OT  - impact localization
OT  - magnetic nanoparticles
OT  - nano-magneto-mechanical activation
OT  - non-heating low frequency magnetic field
OT  - toxicity
COIS- The authors declare no conflict of interest.
EDAT- 2021/09/29 06:00
MHDA- 2021/09/29 06:01
PMCR- 2021/08/31
CRDT- 2021/09/28 01:26
PHST- 2021/07/31 00:00 [received]
PHST- 2021/08/23 00:00 [revised]
PHST- 2021/08/24 00:00 [accepted]
PHST- 2021/09/28 01:26 [entrez]
PHST- 2021/09/29 06:00 [pubmed]
PHST- 2021/09/29 06:01 [medline]
PHST- 2021/08/31 00:00 [pmc-release]
AID - nano11092255 [pii]
AID - nanomaterials-11-02255 [pii]
AID - 10.3390/nano11092255 [doi]
PST - epublish
SO  - Nanomaterials (Basel). 2021 Aug 31;11(9):2255. doi: 10.3390/nano11092255.