PMID- 34578784
OWN - NLM
STAT- MEDLINE
DCOM- 20211112
LR  - 20211112
IS  - 2072-6643 (Electronic)
IS  - 2072-6643 (Linking)
VI  - 13
IP  - 9
DP  - 2021 Aug 24
TI  - Early Appearance of Epicardial Adipose Tissue through Human Development.
LID - 10.3390/nu13092906 [doi]
LID - 2906
AB  - Background: Epicardial adipose tissue (EAT) is a visceral fat depot with unique 
      anatomic, biomolecular and genetic features. Due to its proximity to the coronary 
      arteries and myocardium, dysfunctional EAT may contribute to the development and 
      progression of cardiovascular and metabolic-related adiposity-based chronic 
      diseases. The aim of this work was to describe, by morphological techniques, the 
      early origin of EAT. Methods: EAT adipogenesis was studied in 41 embryos from 32 
      gestational days (GD) to 8 gestational weeks (GW) and in 23 fetuses until full 
      term (from 9 to 36 GW). Results: This process comprises five stages. Stage 1 
      appears as mesenchyme at 33-35 GD. Stage 2 is characterized by angiogenesis at 
      42-45 GD. Stage 3 covers up to 34 GW with the appearance of small fibers in the 
      extracellular matrix. Stage 4 is visible around the coronary arteries, as 
      multilocular adipocytes in primitive fat lobules, and Stage 5 is present with 
      unilocular adipocytes in the definitive fat lobules. EAT precursor tissue appears 
      as early as the end of the first gestational month in the atrioventricular 
      grooves. Unilocular adipocytes appear at the eighth gestational month. 
      Conclusions: Due to its early origin, plasticity and clinical implications, 
      factors such as maternal health and nutrition might influence EAT early 
      development in consequence.
FAU - Perez-Miguelsanz, Juliana
AU  - Perez-Miguelsanz J
AUID- ORCID: 0000-0001-8926-5248
AD  - Departamento de Anatomia y Embriologia, Facultad de Medicina, Universidad 
      Complutense de Madrid, 28040 Madrid, Spain.
AD  - Instituto de Investigacion Sanitaria del Hospital Clinico San Carlos (IdISSC), 
      28003 Madrid, Spain.
FAU - Jimenez-Ortega, Vanesa
AU  - Jimenez-Ortega V
AD  - Instituto de Investigacion Sanitaria del Hospital Clinico San Carlos (IdISSC), 
      28003 Madrid, Spain.
AD  - Departamento de Bioquimica y Biologia Molecular, Facultad de Medicina, 
      Universidad Complutense de Madrid, 28040 Madrid, Spain.
FAU - Cano-Barquilla, Pilar
AU  - Cano-Barquilla P
AD  - Instituto de Investigacion Sanitaria del Hospital Clinico San Carlos (IdISSC), 
      28003 Madrid, Spain.
AD  - Departamento de Bioquimica y Biologia Molecular, Facultad de Medicina, 
      Universidad Complutense de Madrid, 28040 Madrid, Spain.
FAU - Garaulet, Marta
AU  - Garaulet M
AUID- ORCID: 0000-0002-4066-3509
AD  - Departamento de Fisiologia, Universidad de Murcia, IMIB-Arrixaca, 30120 Murcia, 
      Spain.
FAU - Esquifino, Ana I
AU  - Esquifino AI
AD  - Instituto de Investigacion Sanitaria del Hospital Clinico San Carlos (IdISSC), 
      28003 Madrid, Spain.
AD  - Departamento de Bioquimica y Biologia Molecular, Facultad de Medicina, 
      Universidad Complutense de Madrid, 28040 Madrid, Spain.
FAU - Varela-Moreiras, Gregorio
AU  - Varela-Moreiras G
AUID- ORCID: 0000-0001-5158-4999
AD  - Departamento de Ciencias Farmaceuticas y de la Salud, Facultad de Farmacia, 
      Universidad CEU San Pablo, Boadilla del Monte, 28668 Madrid, Spain.
FAU - Fernandez-Mateos, Pilar
AU  - Fernandez-Mateos P
AUID- ORCID: 0000-0002-4113-4756
AD  - Instituto de Investigacion Sanitaria del Hospital Clinico San Carlos (IdISSC), 
      28003 Madrid, Spain.
AD  - Departamento de Biologia Celular, Facultad de Medicina, Universidad Complutense, 
      28040 Madrid, Spain.
LA  - eng
GR  - [grant to Research Groups GR105/18 and GR29/20/Universidad Complutense de Madrid/
GR  - [Grants to Marta Garaulet number SAF2017-84135-R];/Ministerio de Investigacion, 
      Desarrollo e Innovacion y fondos FEDER/
GR  - [to Marta Garaulet number 20795/PI/18 and NIDDK R01DK105072]./Comunidad Autonoma 
      de la Region de Murcia through the Seneca Foundation/
PT  - Journal Article
DEP - 20210824
PL  - Switzerland
TA  - Nutrients
JT  - Nutrients
JID - 101521595
SB  - IM
MH  - Adipocytes/metabolism
MH  - Adipogenesis
MH  - Adipose Tissue/metabolism/*pathology
MH  - Cardiovascular Diseases/*epidemiology
MH  - Coronary Vessels/pathology
MH  - Female
MH  - *Fetal Development
MH  - Fetus/pathology
MH  - Gestational Age
MH  - Humans
MH  - Intra-Abdominal Fat/metabolism
MH  - Myocardium/pathology
MH  - Obesity/*epidemiology
MH  - Pericardium/metabolism/*pathology
MH  - Pregnancy
PMC - PMC8469969
OTO - NOTNLM
OT  - cardiovascular disease
OT  - coronary arteries
OT  - epicardial adipose tissue development
OT  - human embryo and fetus
OT  - metabolic fetal programing
COIS- The authors declare no conflict of interest.
EDAT- 2021/09/29 06:00
MHDA- 2021/11/16 06:00
PMCR- 2021/08/24
CRDT- 2021/09/28 01:27
PHST- 2021/07/19 00:00 [received]
PHST- 2021/08/13 00:00 [revised]
PHST- 2021/08/17 00:00 [accepted]
PHST- 2021/09/28 01:27 [entrez]
PHST- 2021/09/29 06:00 [pubmed]
PHST- 2021/11/16 06:00 [medline]
PHST- 2021/08/24 00:00 [pmc-release]
AID - nu13092906 [pii]
AID - nutrients-13-02906 [pii]
AID - 10.3390/nu13092906 [doi]
PST - epublish
SO  - Nutrients. 2021 Aug 24;13(9):2906. doi: 10.3390/nu13092906.