PMID- 34578846
OWN - NLM
STAT- MEDLINE
DCOM- 20211122
LR  - 20211122
IS  - 2072-6643 (Electronic)
IS  - 2072-6643 (Linking)
VI  - 13
IP  - 9
DP  - 2021 Aug 26
TI  - Concurrent Chemoradiotherapy Induces Body Composition Changes in Locally Advanced 
      Head and Neck Squamous Cell Carcinoma: Comparison between Oral Cavity and 
      Non-Oral Cavity Cancer.
LID - 10.3390/nu13092969 [doi]
LID - 2969
AB  - Few prospective cohort trials have evaluated the difference in treatment-interval 
      total body composition (TBC) changes assessed by dual-energy X-ray absorptiometry 
      (DXA) between two patient subgroups with locally advanced head and neck squamous 
      cell carcinoma (LAHNSCC) receiving concurrent chemoradiotherapy (CCRT): oral 
      cavity cancer with adjuvant CCRT (OCC) and non-oral cavity with primary CCRT 
      (NOCC). This study prospectively recruited patients with LAHNSCC. 
      Clinicopathological variables, blood nutritional/inflammatory markers, 
      CCRT-related factors, and TBC data assessed by DXA before and after treatment 
      were collected. Multivariate linear regression analysis identified the factors 
      associated with treatment-interval changes in body composition parameters, 
      including lean body mass (LBM), total fat mass (TFM), and bone mineral content 
      (BMC). A total of 127 patients (OCC (n = 69) and NOCC (n = 58)) were eligible. 
      Body composition parameters were progressively lost during CCRT in both 
      subgroups. Extremities lost more muscle mass than the trunk for LBM, whereas the 
      trunk lost more fat mass than the extremities for TFM. BMC loss preferentially 
      occurred in the trunk region. Different factors were independently correlated 
      with the interval changes of each body composition parameter for both OCC and 
      NOCC subgroups, particularly mean daily calorie intake for LBM and TFM loss, and 
      total lymphocyte count for BMC loss. In conclusion, treatment-interval TBC 
      changes and related contributing factors differ between the OCC and NOCC 
      subgroups.
FAU - Lin, Yu-Ching
AU  - Lin YC
AUID- ORCID: 0000-0002-2318-8507
AD  - Department of Medical Imaging and Intervention, Chang Gung Memorial Hospital, 
      College of Medicine, Keelung & Chang Gung University, Taoyuan 333007, Taiwan.
AD  - Osteoporosis Prevention and Treatment Center, Chang Gung Memorial Hospital, 
      Keelung 20401, Taiwan.
FAU - Ling, Hang Huong
AU  - Ling HH
AUID- ORCID: 0000-0003-4662-1235
AD  - Division of Hemato-Oncology, Department of Internal Medicine, Chang Gung Memorial 
      Hospital, College of Medicine, Keelung & Chang Gung University, Taoyuan 333007, 
      Taiwan.
FAU - Chang, Pei-Hung
AU  - Chang PH
AD  - Division of Hemato-Oncology, Department of Internal Medicine, Chang Gung Memorial 
      Hospital, College of Medicine, Keelung & Chang Gung University, Taoyuan 333007, 
      Taiwan.
FAU - Pan, Yi-Ping
AU  - Pan YP
AD  - Department of Nutrition, Chang Gung Memorial Hospital, Keelung 20401, Taiwan.
FAU - Wang, Cheng-Hsu
AU  - Wang CH
AD  - Division of Hemato-Oncology, Department of Internal Medicine, Chang Gung Memorial 
      Hospital, College of Medicine, Keelung & Chang Gung University, Taoyuan 333007, 
      Taiwan.
FAU - Chou, Wen-Chi
AU  - Chou WC
AD  - Division of Hemato-Oncology, Department of Internal Medicine, Chang Gung Memorial 
      Hospital, College of Medicine, Linkou & Chang Gung University, Taoyuan 333007, 
      Taiwan.
FAU - Chen, Fang-Ping
AU  - Chen FP
AUID- ORCID: 0000-0001-5228-5755
AD  - Osteoporosis Prevention and Treatment Center, Chang Gung Memorial Hospital, 
      Keelung 20401, Taiwan.
AD  - Department of Obstetrics and Gynecology, Chang Gung Memorial Hospital, Keelung 
      20401, Taiwan.
AD  - Healthy Aging Research Center, College of Medicine, Chang Gung University, 
      Taoyuan 333007, Taiwan.
FAU - Yeh, Kun-Yun
AU  - Yeh KY
AUID- ORCID: 0000-0001-5572-7897
AD  - Division of Hemato-Oncology, Department of Internal Medicine, Chang Gung Memorial 
      Hospital, College of Medicine, Keelung & Chang Gung University, Taoyuan 333007, 
      Taiwan.
LA  - eng
GR  - MOST 108-2314-B-182A-018-MY3/Ministry of Science and Technology, Taiwan/
GR  - CMRPG2E0101-CMRPG2E0103, CMRPG2J0171, CMRPG2G0611, and CORPG2F0011-13/Chang Gung 
      Memorial Hospital/
PT  - Comparative Study
PT  - Journal Article
DEP - 20210826
PL  - Switzerland
TA  - Nutrients
JT  - Nutrients
JID - 101521595
SB  - IM
MH  - Body Composition/*physiology
MH  - Bone Density/physiology
MH  - Chemoradiotherapy/*methods
MH  - Cohort Studies
MH  - Female
MH  - Head and Neck Neoplasms/physiopathology/*therapy
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Mouth Neoplasms/physiopathology/therapy
MH  - Prospective Studies
MH  - Squamous Cell Carcinoma of Head and Neck/physiopathology/*therapy
PMC - PMC8472371
OTO - NOTNLM
OT  - DXA
OT  - bone mineral content
OT  - concurrent chemoradiotherapy
OT  - head and neck cancer
OT  - lean body mass
OT  - total fat mass
COIS- The authors declare no conflict of interest.
EDAT- 2021/09/29 06:00
MHDA- 2021/11/23 06:00
PMCR- 2021/08/26
CRDT- 2021/09/28 01:27
PHST- 2021/08/01 00:00 [received]
PHST- 2021/08/22 00:00 [revised]
PHST- 2021/08/24 00:00 [accepted]
PHST- 2021/09/28 01:27 [entrez]
PHST- 2021/09/29 06:00 [pubmed]
PHST- 2021/11/23 06:00 [medline]
PHST- 2021/08/26 00:00 [pmc-release]
AID - nu13092969 [pii]
AID - nutrients-13-02969 [pii]
AID - 10.3390/nu13092969 [doi]
PST - epublish
SO  - Nutrients. 2021 Aug 26;13(9):2969. doi: 10.3390/nu13092969.