PMID- 34578880
OWN - NLM
STAT- MEDLINE
DCOM- 20211117
LR  - 20240226
IS  - 2072-6643 (Electronic)
IS  - 2072-6643 (Linking)
VI  - 13
IP  - 9
DP  - 2021 Aug 28
TI  - Caloric Restriction per se Rather Than Dietary Macronutrient Distribution Plays a 
      Primary Role in Metabolic Health and Body Composition Improvements in Obese Mice.
LID - 10.3390/nu13093004 [doi]
LID - 3004
AB  - Caloric restriction (CR) is of key importance in combating obesity and its 
      associated diseases. We aimed to examine effects of dietary macronutrient 
      distribution on weight loss and metabolic health in obese mice exposed to CR. 
      Male C57BL/6J mice underwent diet-induced obesity for 18 weeks. Thereafter mice 
      were exposed to a 6-week CR for up to 40% on either low-fat diet (LFD; 20, 60, 
      20% kcal from protein, carbohydrate, fat), low-carb diet (LCD; 20, 20, 60% kcal, 
      respectively) or high-pro diet (HPD; 35, 35, 30% kcal, respectively) (n = 16 
      each). Ten mice on the obesogenic diet served as age-matched controls. Body 
      composition was evaluated by tissue dissections. Glucose tolerance, bloods lipids 
      and energy metabolism were measured. CR-induced weight loss was similar for LFD 
      and LCD while HPD was associated with a greater weight loss than LCD. The diet 
      groups did not differ from obese controls in hindlimb muscle mass, but showed a 
      substantial decrease in body fat without differences between them. Glucose 
      tolerance and blood total cholesterol were weight-loss dependent and mostly 
      improved in LFD and HPD groups during CR. Blood triacylglycerol was lowered only 
      in LCD group compared to obese controls. Thus, CR rather than macronutrient 
      distribution in the diet plays the major role for improvements in body 
      composition and glucose control in obese mice. Low-carbohydrate-high-fat diet 
      more successfully reduces triacylglycerol but not cholesterol levels compared to 
      isocaloric high-carbohydrate-low-fat weight loss diets.
FAU - Minderis, Petras
AU  - Minderis P
AUID- ORCID: 0000-0001-9522-6050
AD  - Institute of Sport Science and Innovations, Lithuanian Sports University, 44221 
      Kaunas, Lithuania.
FAU - Fokin, Andrej
AU  - Fokin A
AD  - Institute of Sport Science and Innovations, Lithuanian Sports University, 44221 
      Kaunas, Lithuania.
FAU - Dirmontas, Mantas
AU  - Dirmontas M
AD  - Department of Health Promotion and Rehabilitation, Lithuanian Sports University, 
      44221 Kaunas, Lithuania.
FAU - Kvedaras, Mindaugas
AU  - Kvedaras M
AD  - Institute of Sport Science and Innovations, Lithuanian Sports University, 44221 
      Kaunas, Lithuania.
FAU - Ratkevicius, Aivaras
AU  - Ratkevicius A
AUID- ORCID: 0000-0002-4737-5817
AD  - Institute of Sport Science and Innovations, Lithuanian Sports University, 44221 
      Kaunas, Lithuania.
AD  - Department of Health Promotion and Rehabilitation, Lithuanian Sports University, 
      44221 Kaunas, Lithuania.
LA  - eng
PT  - Journal Article
DEP - 20210828
PL  - Switzerland
TA  - Nutrients
JT  - Nutrients
JID - 101521595
RN  - 0 (Blood Glucose)
RN  - 0 (Dietary Carbohydrates)
RN  - 0 (Dietary Fats)
RN  - 0 (Triglycerides)
RN  - 97C5T2UQ7J (Cholesterol)
SB  - IM
MH  - Adipose Tissue/*metabolism
MH  - Animals
MH  - Blood Glucose/*metabolism
MH  - *Body Composition
MH  - *Caloric Restriction
MH  - Cholesterol/blood
MH  - *Diet
MH  - Diet, Carbohydrate-Restricted
MH  - Diet, Fat-Restricted
MH  - Diet, High-Fat
MH  - Dietary Carbohydrates/administration & dosage
MH  - Dietary Fats/administration & dosage
MH  - Energy Metabolism
MH  - Glucose Intolerance/prevention & control
MH  - Male
MH  - Mice, Inbred C57BL
MH  - Mice, Obese
MH  - Muscles/metabolism
MH  - Nutrients/*administration & dosage
MH  - Obesity/*therapy
MH  - Triglycerides/blood
MH  - Weight Loss
MH  - Mice
PMC - PMC8466799
OTO - NOTNLM
OT  - diets
OT  - high-protein
OT  - low-carbohydrate
OT  - low-fat
OT  - weight loss
COIS- The authors declare no conflict of interest.
EDAT- 2021/09/29 06:00
MHDA- 2021/11/18 06:00
PMCR- 2021/08/28
CRDT- 2021/09/28 01:27
PHST- 2021/07/14 00:00 [received]
PHST- 2021/08/19 00:00 [revised]
PHST- 2021/08/26 00:00 [accepted]
PHST- 2021/09/28 01:27 [entrez]
PHST- 2021/09/29 06:00 [pubmed]
PHST- 2021/11/18 06:00 [medline]
PHST- 2021/08/28 00:00 [pmc-release]
AID - nu13093004 [pii]
AID - nutrients-13-03004 [pii]
AID - 10.3390/nu13093004 [doi]
PST - epublish
SO  - Nutrients. 2021 Aug 28;13(9):3004. doi: 10.3390/nu13093004.