PMID- 34578989
OWN - NLM
STAT- MEDLINE
DCOM- 20211119
LR  - 20211119
IS  - 2072-6643 (Electronic)
IS  - 2072-6643 (Linking)
VI  - 13
IP  - 9
DP  - 2021 Sep 4
TI  - Effects of Acute Fructose Loading on Markers of Inflammation-A Pilot Study.
LID - 10.3390/nu13093110 [doi]
LID - 3110
AB  - Inflammation plays a role in development of diabetic complications. The 
      postprandial state has been linked to chronic low grade inflammation. We 
      therefore aimed to investigate the acute effects of fructose loading, with and 
      without a pizza, on metabolic and inflammatory markers in patients with type 2 
      diabetes (T2D) (n = 7) and in healthy subjects (HS) (n = 6), age 47-76 years. 
      Drinks consumed were blueberry drink (18 g fructose), Coca-Cola (17.5 g 
      fructose), and fructose drink (35 g fructose). The levels of glucose, insulin, 
      insulin-like growth factor binding protein-1 (IGFBP-1) and inflammatory markers: 
      Interleukin-6 (IL-6), Monocyte chemoattractant protein-1 (MCP-1), Interleukin-18 
      (IL-18), Intercellular Adhesion Molecule 1 (ICAM-1), vascular cell adhesion 
      molecule 1 (VCAM-1), and bacterial lipopolysaccharides (LPS) were analyzed in 
      blood. The postprandial responses were assessed using Wilcoxon's matched-pairs 
      test, Friedman's ANOVA and Mann-Whitney U test. There was no difference in 
      baseline levels of inflammatory markers between the groups. In T2D, MCP-1 
      decreased following blueberry drink and Coca-Cola (p = 0.02), Coca-Cola + pizza 
      and fructose + pizza (p = 0.03). In HS, IL-6 increased following blueberry + 
      pizza and fructose + pizza (p = 0.03), there was a decrease in MCP-1 following 
      blueberry drink and Coca-Cola (p = 0.03), and in ICAM-1 following blueberry + 
      pizza (p = 0.03). These results may indicate a role for MCP-1 as a link between 
      postprandial state and diabetes complications, however further mechanistic 
      studies on larger population of patients with T2D are needed for confirmation of 
      these results.
FAU - Olofsson, Camilla
AU  - Olofsson C
AD  - Department of Molecular Medicine and Surgery, Karolinska Institutet, 171 77 
      Stockholm, Sweden.
FAU - Eriksson, Monica
AU  - Eriksson M
AD  - Division of Renal Medicine M99, CLINTEC, Karolinska Institutet, 171 77 Stockholm, 
      Sweden.
FAU - Bragfors Helin, Ann-Christin
AU  - Bragfors Helin AC
AD  - Division of Renal Medicine M99, CLINTEC, Karolinska Institutet, 171 77 Stockholm, 
      Sweden.
FAU - Anderstam, Bjorn
AU  - Anderstam B
AD  - Division of Renal Medicine M99, CLINTEC, Karolinska Institutet, 171 77 Stockholm, 
      Sweden.
FAU - Orsini, Nicola
AU  - Orsini N
AD  - Department of Global Public Health, Karolinska Institutet, 171 77 Stockholm, 
      Sweden.
FAU - Stenvinkel, Peter
AU  - Stenvinkel P
AD  - Division of Renal Medicine M99, CLINTEC, Karolinska Institutet, 171 77 Stockholm, 
      Sweden.
FAU - Rajamand Ekberg, Neda
AU  - Rajamand Ekberg N
AUID- ORCID: 0000-0001-5597-2593
AD  - Department of Molecular Medicine and Surgery, Karolinska Institutet, 171 77 
      Stockholm, Sweden.
AD  - Department of Endocrinology, Karolinska University Hospital, 171 76 Stockholm, 
      Sweden.
AD  - Centre for Diabetes, Academic Specialist Centre, 113 65 Stockholm, Sweden.
LA  - eng
GR  - 1, 2, 3/(1) Diabetic Theme Centre, (2) Swedish Research Council and (3)the Family 
      Erling Persson Foundation/
PT  - Journal Article
DEP - 20210904
PL  - Switzerland
TA  - Nutrients
JT  - Nutrients
JID - 101521595
RN  - 0 (Biomarkers)
RN  - 0 (Blood Glucose)
RN  - 0 (CCL2 protein, human)
RN  - 0 (Chemokine CCL2)
RN  - 0 (ICAM1 protein, human)
RN  - 0 (IL18 protein, human)
RN  - 0 (IL6 protein, human)
RN  - 0 (Insulin)
RN  - 0 (Interleukin-18)
RN  - 0 (Interleukin-6)
RN  - 0 (Vascular Cell Adhesion Molecule-1)
RN  - 126547-89-5 (Intercellular Adhesion Molecule-1)
RN  - 30237-26-4 (Fructose)
SB  - IM
MH  - Aged
MH  - Biomarkers/blood
MH  - Blood Glucose/analysis
MH  - Carbonated Beverages/adverse effects
MH  - Chemokine CCL2/blood
MH  - Diabetes Mellitus, Type 2/complications/metabolism
MH  - Female
MH  - Fructose/administration & dosage/*adverse effects
MH  - Fruit and Vegetable Juices
MH  - Humans
MH  - Inflammation/blood/*chemically induced
MH  - Insulin/blood
MH  - Intercellular Adhesion Molecule-1/blood
MH  - Interleukin-18/blood
MH  - Interleukin-6/blood
MH  - Male
MH  - Middle Aged
MH  - Pilot Projects
MH  - Vascular Cell Adhesion Molecule-1/blood
PMC - PMC8465001
OTO - NOTNLM
OT  - IGFBP-1
OT  - IL-6
OT  - MCP-1
OT  - fructose loading
OT  - inflammatory markers
OT  - type 2 diabetes
COIS- The authors declare that they have no conflict of interest.
EDAT- 2021/09/29 06:00
MHDA- 2021/11/20 06:00
PMCR- 2021/09/04
CRDT- 2021/09/28 01:28
PHST- 2021/06/22 00:00 [received]
PHST- 2021/08/30 00:00 [revised]
PHST- 2021/09/01 00:00 [accepted]
PHST- 2021/09/28 01:28 [entrez]
PHST- 2021/09/29 06:00 [pubmed]
PHST- 2021/11/20 06:00 [medline]
PHST- 2021/09/04 00:00 [pmc-release]
AID - nu13093110 [pii]
AID - nutrients-13-03110 [pii]
AID - 10.3390/nu13093110 [doi]
PST - epublish
SO  - Nutrients. 2021 Sep 4;13(9):3110. doi: 10.3390/nu13093110.