PMID- 34579213
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240214
IS  - 2076-393X (Print)
IS  - 2076-393X (Electronic)
IS  - 2076-393X (Linking)
VI  - 9
IP  - 9
DP  - 2021 Aug 31
TI  - P80 Natural Essence Exerts Efficient Anti-HIV-1- as Well as Adjuvant Effects in 
      DCs.
LID - 10.3390/vaccines9090976 [doi]
LID - 976
AB  - Dendritic cells (DCs), as well as complement, play a major role during human 
      immunodeficiency virus 1 (HIV-1) entry and infection at mucosal sites. Together, 
      DCs and complement are key points for understanding host defence against HIV-1 
      infection and for studying the impact of new drugs on the regulation of innate 
      host-pathogen interactions and adaptive immunity. For this, we evaluated the 
      antiviral effect of the P80 natural essence (Longan extract) on interactions of 
      non- and complement-opsonized HIV-1 with DCs. In viability assays, we first 
      illustrated the effects of P80 natural essence on DC function. We found that P80 
      concentrations above 1.5% caused increased cell death, while at concentrations 
      between 0.5% and 1% the compound exerted efficient antiviral effects in DCs and 
      illustrated an adjuvant effect regarding DC activation. DC maturation, as well as 
      co-stimulatory capacity, were significantly improved by P80 natural essence via 
      p38 MAPK phosphorylation in presence of the viral challenge independent of the 
      opsonization pattern. These findings might be exploited for future therapeutic 
      options to target DC subsets directly at mucosal sites by P80 natural essence and 
      to block entry of both, non- and complement-opsonized HIV-1.
FAU - Zaderer, Viktoria
AU  - Zaderer V
AUID- ORCID: 0000-0002-0507-0513
AD  - Institute of Hygiene and Medical Microbiology, Medical University of Innsbruck, 
      6020 Innsbruck, Austria.
FAU - Posch, Wilfried
AU  - Posch W
AUID- ORCID: 0000-0001-8955-7654
AD  - Institute of Hygiene and Medical Microbiology, Medical University of Innsbruck, 
      6020 Innsbruck, Austria.
FAU - Gstir, Ronald
AU  - Gstir R
AD  - ADSI-Austrian Drug Screening Institute GmbH, 6020 Innsbruck, Austria.
FAU - Filipek, Przemyslaw A
AU  - Filipek PA
AUID- ORCID: 0000-0003-3125-4532
AD  - ADSI-Austrian Drug Screening Institute GmbH, 6020 Innsbruck, Austria.
FAU - Bonn, Gunther K
AU  - Bonn GK
AD  - ADSI-Austrian Drug Screening Institute GmbH, 6020 Innsbruck, Austria.
FAU - Aramwit, Pornanong
AU  - Aramwit P
AD  - Department of Pharmacy Practice, Faculty of Pharmaceutical Sciences and Center of 
      Excellence in Bioactive Resources for Innovative Clinical Applications, 
      Chulalongkorn University, Bangkok 10330, Thailand.
FAU - Huber, Lukas A
AU  - Huber LA
AUID- ORCID: 0000-0003-1116-2120
AD  - ADSI-Austrian Drug Screening Institute GmbH, 6020 Innsbruck, Austria.
AD  - Institute of Cell Biology, Biocenter Innsbruck, Medical University of Innsbruck, 
      6020 Innsbruck, Austria.
FAU - Wilflingseder, Doris
AU  - Wilflingseder D
AUID- ORCID: 0000-0002-5888-5118
AD  - Institute of Hygiene and Medical Microbiology, Medical University of Innsbruck, 
      6020 Innsbruck, Austria.
LA  - eng
GR  - DOC 82/FWF_/Austrian Science Fund FWF/Austria
GR  - P 33510/FWF_/Austrian Science Fund FWF/Austria
GR  - P33510-B13/FWF_/Austrian Science Fund FWF/Austria
PT  - Journal Article
DEP - 20210831
PL  - Switzerland
TA  - Vaccines (Basel)
JT  - Vaccines
JID - 101629355
PMC - PMC8472994
OTO - NOTNLM
OT  - HIV-1
OT  - P80 natural essence
OT  - complement
OT  - dendritic cells
COIS- No competing interests or conflicts of interest to declare. The study design, 
      analysis, interpretation and conclusions were not influenced by the funding 
      organizations.
EDAT- 2021/09/29 06:00
MHDA- 2021/09/29 06:01
PMCR- 2021/08/31
CRDT- 2021/09/28 01:28
PHST- 2021/04/06 00:00 [received]
PHST- 2021/08/18 00:00 [revised]
PHST- 2021/08/26 00:00 [accepted]
PHST- 2021/09/28 01:28 [entrez]
PHST- 2021/09/29 06:00 [pubmed]
PHST- 2021/09/29 06:01 [medline]
PHST- 2021/08/31 00:00 [pmc-release]
AID - vaccines9090976 [pii]
AID - vaccines-09-00976 [pii]
AID - 10.3390/vaccines9090976 [doi]
PST - epublish
SO  - Vaccines (Basel). 2021 Aug 31;9(9):976. doi: 10.3390/vaccines9090976.