PMID- 34581307
OWN - NLM
STAT- MEDLINE
DCOM- 20220408
LR  - 20230921
IS  - 1473-5571 (Electronic)
IS  - 0269-9370 (Print)
IS  - 0269-9370 (Linking)
VI  - 36
IP  - 4
DP  - 2022 Mar 15
TI  - Distinct antibody profiles in HLA-B *57+, HLA-B *57- HIV controllers and chronic 
      progressors.
PG  - 487-499
LID - 10.1097/QAD.0000000000003080 [doi]
AB  - OBJECTIVE: Spontaneous control of HIV replication without treatment in HIV-1 
      controllers (HICs) was associated with the development of an efficient T-cell 
      response. In addition, increasing data suggest that the humoral response 
      participates in viral clearance. DESIGN: In-depth characterization of Ab response 
      in HICs may help to define new parameters associated with this control. METHODS: 
      We assessed the levels of total and HIV-specific IgA and IgG subtypes induction 
      and their functional potencies - that is, neutralization, phagocytosis, 
      antibody-dependent cellular cytotoxicity (ADCC), according to the individual's 
      major histocompatibility complex class I (HLA)-B *57 status, and compared it with 
      nontreated chronic progressors. RESULTS: We found that despite an undetectable 
      viral load, HICs displayed HIV-specific IgG levels similar to those of chronic 
      progressors. Interestingly, our compelling multifunctional analysis demonstrates 
      that the functional Ab profile, by itself, allowed to discriminate HLA-B *57+ HICs 
      from HLA-B *57- HICs and chronic progressors. CONCLUSION: These results show that 
      HICs display a particular HIV-specific antibody (Ab) profile that may participate 
      in HIV control and emphasize the relevance of multifunctional Ab response 
      analysis in future Ab-driven vaccine studies.
CI  - Copyright (c) 2021 The Author(s). Published by Wolters Kluwer Health, Inc.
FAU - Klingler, Jeromine
AU  - Klingler J
AD  - INSERM UMR_S 1109, Centre de Recherche en Immunologie et Hematologie, Faculte de 
      Medecine, Federation de Medecine Translationnelle de Strasbourg (FMTS), LabEx 
      Transplantex, Universite de Strasbourg, Strasbourg.
FAU - Paul, Nicodeme
AU  - Paul N
AD  - INSERM UMR_S 1109, Centre de Recherche en Immunologie et Hematologie, Faculte de 
      Medecine, Federation de Medecine Translationnelle de Strasbourg (FMTS), LabEx 
      Transplantex, Universite de Strasbourg, Strasbourg.
FAU - Laumond, Geraldine
AU  - Laumond G
AD  - INSERM UMR_S 1109, Centre de Recherche en Immunologie et Hematologie, Faculte de 
      Medecine, Federation de Medecine Translationnelle de Strasbourg (FMTS), LabEx 
      Transplantex, Universite de Strasbourg, Strasbourg.
FAU - Schmidt, Sylvie
AU  - Schmidt S
AD  - INSERM UMR_S 1109, Centre de Recherche en Immunologie et Hematologie, Faculte de 
      Medecine, Federation de Medecine Translationnelle de Strasbourg (FMTS), LabEx 
      Transplantex, Universite de Strasbourg, Strasbourg.
FAU - Mayr, Luzia M
AU  - Mayr LM
AD  - INSERM UMR_S 1109, Centre de Recherche en Immunologie et Hematologie, Faculte de 
      Medecine, Federation de Medecine Translationnelle de Strasbourg (FMTS), LabEx 
      Transplantex, Universite de Strasbourg, Strasbourg.
FAU - Decoville, Thomas
AU  - Decoville T
AD  - INSERM UMR_S 1109, Centre de Recherche en Immunologie et Hematologie, Faculte de 
      Medecine, Federation de Medecine Translationnelle de Strasbourg (FMTS), LabEx 
      Transplantex, Universite de Strasbourg, Strasbourg.
AD  - Vaccine Research Institute (VRI), Creteil.
FAU - Lambotte, Olivier
AU  - Lambotte O
AD  - Universite Paris Sud.
AD  - INSERM UMR-1184, Center for Immunology of Viral Infections and Autoimmune 
      Diseases, Le Kremlin Bicetre.
AD  - CEA, DSV/iMETI, Division of Immuno-Virology, IDMIT, Fontenay-aux-Roses.
AD  - AP-HP, Service de Meecine Interne-Immunologie Clinique, Hopitaux Universitaires 
      Paris Sud, Le Kremlin Bicetre.
FAU - Autran, Brigitte
AU  - Autran B
AD  - Sorbonne Universites, UPMC Univ Paris 06, INSERM U1135, Center for Immunology and 
      Microbial Infections - CIMI-Paris.
AD  - AP-HP, Hopital Pitie-Salpetiere, Department of Immunology, Paris, France.
FAU - Bahram, Seiamak
AU  - Bahram S
AD  - INSERM UMR_S 1109, Centre de Recherche en Immunologie et Hematologie, Faculte de 
      Medecine, Federation de Medecine Translationnelle de Strasbourg (FMTS), LabEx 
      Transplantex, Universite de Strasbourg, Strasbourg.
FAU - Moog, Christiane
AU  - Moog C
AD  - INSERM UMR_S 1109, Centre de Recherche en Immunologie et Hematologie, Faculte de 
      Medecine, Federation de Medecine Translationnelle de Strasbourg (FMTS), LabEx 
      Transplantex, Universite de Strasbourg, Strasbourg.
AD  - Vaccine Research Institute (VRI), Creteil.
CN  - and for ANRS CO21 Cohort
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - AIDS
JT  - AIDS (London, England)
JID - 8710219
RN  - 0 (HIV Antibodies)
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-B57 antigen)
RN  - 0 (Immunoglobulin G)
SB  - IM
MH  - HIV Antibodies
MH  - *HIV Infections
MH  - HIV Non-Progressors
MH  - *HIV-1
MH  - HLA-B Antigens
MH  - Humans
MH  - Immunoglobulin G
MH  - Viral Load
PMC - PMC8876439
COIS- The authors declare no competing interests.
EDAT- 2021/09/29 06:00
MHDA- 2022/04/09 06:00
PMCR- 2022/02/25
CRDT- 2021/09/28 09:48
PHST- 2021/09/29 06:00 [pubmed]
PHST- 2022/04/09 06:00 [medline]
PHST- 2021/09/28 09:48 [entrez]
PHST- 2022/02/25 00:00 [pmc-release]
AID - 00002030-202203150-00002 [pii]
AID - AIDS-D-21-00625 [pii]
AID - 10.1097/QAD.0000000000003080 [doi]
PST - ppublish
SO  - AIDS. 2022 Mar 15;36(4):487-499. doi: 10.1097/QAD.0000000000003080.