PMID- 34582103
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220716
IS  - 2045-7022 (Print)
IS  - 2045-7022 (Electronic)
IS  - 2045-7022 (Linking)
VI  - 11
IP  - 7
DP  - 2021 Aug
TI  - Integration of in vitro allergy test results and ratio analysis for the diagnosis 
      and treatment of allergic patients (INTEGRA).
PG  - e12052
LID - 10.1002/clt2.12052 [doi]
LID - e12052
AB  - The introduction of molecular diagnosis into routine clinical practice has 
      substantially improved the diagnosis and management of allergic patients by 
      allowing clinicians to precisely identify the allergenic molecule responsible for 
      immunoglobulin E (IgE)-mediated allergies. However, it can be challenging to 
      accurately interpret the results of molecular assays, partly due to the limited 
      evidence base. In this context, a panel of experts with extensive experience in 
      interpreting in vitro measures of total and serum specific IgE reviewed the 
      available scientific evidence. After this review, the panel selected a series of 
      representative case studies to demonstrate how determination of specific and 
      total IgE values and the relationship between them (ratio analysis) can add value 
      to the diagnostic process by more precisely defining the patient's sensitization 
      profile. Finally, the experts developed a series of recommendations on the 
      clinical application of ratio analysis to optimize and complement the classical 
      approach to allergy diagnosis.
CI  - (c) 2021 The Authors. Clinical and Translational Allergy published by John Wiley & 
      Sons Ltd on behalf of European Academy of Allergy and Clinical Immunology.
FAU - Pascal, Mariona
AU  - Pascal M
AD  - Immunology Department, Centre de Diagnostic Biomedic, Hospital Clinic de 
      Barcelona, Institut d'Investigacions Biomediques August Pi i Sunyer (IDIBAPS), 
      Universitat de Barcelona, Barcelona, Spain.
AD  - ARADyAL Network, Health Institute Carlos III, Madrid, Spain.
FAU - Moreno, Carmen
AU  - Moreno C
AD  - ARADyAL Network, Health Institute Carlos III, Madrid, Spain.
AD  - Allergy Service, Hospital Universitario Reina Sofia, Maimonides Biomedical 
      Research Institute of Cordoba (IMIBIC), Cordoba, Spain.
FAU - Davila, Ignacio
AU  - Davila I
AD  - ARADyAL Network, Health Institute Carlos III, Madrid, Spain.
AD  - Allergy Service, Department of Biomedical and Diagnostic Sciences and Institute 
      for Biomedical Research of Salamanca (IBSAL), University Hospital of Salamanca, 
      Salamanca, Spain.
FAU - Tabar, Ana I
AU  - Tabar AI
AD  - ARADyAL Network, Health Institute Carlos III, Madrid, Spain.
AD  - Allergy Service, Hospital Complex of Navarra, Pamplona, Spain.
AD  - Navarra Institute for Health Research (IdiSNA), Cooperative Health Research 
      Thematic Networks (RETICs) for Asthma, Madrid, Spain.
FAU - Bartra, Joan
AU  - Bartra J
AD  - ARADyAL Network, Health Institute Carlos III, Madrid, Spain.
AD  - Allergy Section, Pneumology Department, Hospital Clinic de Barcelona, Institut 
      d'Investigacions Biomediques August Pi i Sunyer (IDIBAPS), Universitat de 
      Barcelona, Barcelona, Spain.
FAU - Labrador, Moises
AU  - Labrador M
AD  - ARADyAL Network, Health Institute Carlos III, Madrid, Spain.
AD  - Allergy Section, Internal Medicine Department, Hospital Universitari Vall 
      d Hebron, Institut de Recerca Vall d'Hebron (VHIR), Universitat Autonoma de 
      Barcelona. Barcelona, Spain.
FAU - Luengo, Olga
AU  - Luengo O
AUID- ORCID: 0000-0002-8905-2776
AD  - ARADyAL Network, Health Institute Carlos III, Madrid, Spain.
AD  - Allergy Section, Internal Medicine Department, Hospital Universitari Vall 
      d Hebron, Institut de Recerca Vall d'Hebron (VHIR), Universitat Autonoma de 
      Barcelona. Barcelona, Spain.
LA  - eng
GR  - Thermo Fisher Scientific/
PT  - Journal Article
PT  - Review
PL  - England
TA  - Clin Transl Allergy
JT  - Clinical and translational allergy
JID - 101576043
PMC - PMC9082998
OTO - NOTNLM
OT  - IgE
OT  - IgE ratio
OT  - allergy
OT  - molecular diagnosis
OT  - recommendations
COIS- The authors have received consulting fees and financial support from Thermo 
      Fisher Scientific to attend workshops related to the preparation of this article.
EDAT- 2021/09/29 06:00
MHDA- 2021/09/29 06:01
PMCR- 2021/09/16
CRDT- 2021/09/28 12:33
PHST- 2021/07/05 00:00 [revised]
PHST- 2021/05/11 00:00 [received]
PHST- 2021/07/30 00:00 [accepted]
PHST- 2021/09/28 12:33 [entrez]
PHST- 2021/09/29 06:00 [pubmed]
PHST- 2021/09/29 06:01 [medline]
PHST- 2021/09/16 00:00 [pmc-release]
AID - CLT212052 [pii]
AID - 10.1002/clt2.12052 [doi]
PST - ppublish
SO  - Clin Transl Allergy. 2021 Aug;11(7):e12052. doi: 10.1002/clt2.12052.