PMID- 34582711
OWN - NLM
STAT- MEDLINE
DCOM- 20220207
LR  - 20230103
IS  - 2046-2441 (Electronic)
IS  - 2046-2441 (Linking)
VI  - 11
IP  - 9
DP  - 2021 Sep
TI  - ANGPTL8 in metabolic homeostasis: more friend than foe?
PG  - 210106
LID - 10.1098/rsob.210106 [doi]
LID - 210106
AB  - ANGPTL8 is an important cytokine, which is significantly increased in type 2 
      diabetes mellitus (T2DM), obesity and metabolic syndrome. Many studies have shown 
      that ANGPTL8 can be used as a bio-marker of these metabolic disorders related 
      diseases, and the baseline ANGPTL8 level has also been found to be positively 
      correlated with retinopathy and all-cause mortality in patients with T2DM. This 
      may be related to the inhibition of lipoprotein lipase activity and the reduction 
      of circulating triglyceride (TG) clearance by ANGPTL8. Consistently, inhibition 
      of ANGPTL8 seems to prevent or improve atherosclerosis. However, it is puzzling 
      that ANGPTL8 seems to have a directing function for TG uptake in peripheral 
      tissues; that is, ANGPTL8 specifically enhances the reserve and buffering 
      function of white adipose tissue, which may alleviate the ectopic lipid 
      accumulation to a certain extent. Furthermore, ANGPTL8 can improve insulin 
      sensitivity and inhibit hepatic glucose production. These contradictory results 
      lead to different opinions on the role of ANGPTL8 in metabolic disorders. In this 
      paper, the correlation between ANGPTL8 and metabolic diseases, the regulation of 
      ANGPTL8 and the physiological role of ANGPTL8 in the process of glucose and lipid 
      metabolism were summarized, and the physiological/pathological significance of 
      ANGPTL8 in the process of metabolic disorder was discussed.
FAU - Guo, Chang
AU  - Guo C
AUID- ORCID: 0000-0003-3239-2080
AD  - Department of Nephrology, Affiliated Hospital of Jiangsu University, 438 Jiefang 
      Road, Zhenjiang 212001, Jiangsu, People's Republic of China.
FAU - Wang, Chenxi
AU  - Wang C
AD  - Department of Endocrinology, Affiliated Hospital of Jiangsu University, 438 
      Jiefang Road, Zhenjiang 212001, Jiangsu, People's Republic of China.
FAU - Deng, Xia
AU  - Deng X
AUID- ORCID: 0000-0003-1806-9041
AD  - Department of Endocrinology, Affiliated Hospital of Jiangsu University, 438 
      Jiefang Road, Zhenjiang 212001, Jiangsu, People's Republic of China.
FAU - He, Jianqiang
AU  - He J
AD  - Department of Nephrology, Affiliated Hospital of Jiangsu University, 438 Jiefang 
      Road, Zhenjiang 212001, Jiangsu, People's Republic of China.
FAU - Yang, Ling
AU  - Yang L
AD  - Department of Endocrinology, Affiliated Hospital of Jiangsu University, 438 
      Jiefang Road, Zhenjiang 212001, Jiangsu, People's Republic of China.
FAU - Yuan, Guoyue
AU  - Yuan G
AUID- ORCID: 0000-0003-0822-6066
AD  - Department of Endocrinology, Affiliated Hospital of Jiangsu University, 438 
      Jiefang Road, Zhenjiang 212001, Jiangsu, People's Republic of China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20210929
PL  - England
TA  - Open Biol
JT  - Open biology
JID - 101580419
RN  - 0 (ANGPTL8 protein, human)
RN  - 0 (Angiopoietin-Like Protein 8)
RN  - 0 (Peptide Hormones)
SB  - IM
MH  - Angiopoietin-Like Protein 8/*metabolism
MH  - *Homeostasis
MH  - Humans
MH  - Metabolic Diseases/metabolism/*pathology
MH  - Peptide Hormones/*metabolism
PMC - PMC8478524
OTO - NOTNLM
OT  - ANGPTL8
OT  - T2DM
OT  - betatrophin
OT  - glucose metabolism
OT  - lipid metabolism
COIS- All authors have nothing to declare.
EDAT- 2021/09/29 06:00
MHDA- 2022/02/08 06:00
PMCR- 2021/09/29
CRDT- 2021/09/28 20:12
PHST- 2021/09/28 20:12 [entrez]
PHST- 2021/09/29 06:00 [pubmed]
PHST- 2022/02/08 06:00 [medline]
PHST- 2021/09/29 00:00 [pmc-release]
AID - rsob210106 [pii]
AID - 10.1098/rsob.210106 [doi]
PST - ppublish
SO  - Open Biol. 2021 Sep;11(9):210106. doi: 10.1098/rsob.210106. Epub 2021 Sep 29.