PMID- 3458307
OWN - NLM
STAT- MEDLINE
DCOM- 19860612
LR  - 20190618
IS  - 0036-8075 (Print)
IS  - 0036-8075 (Linking)
VI  - 232
IP  - 4754
DP  - 1986 May 30
TI  - Gene interaction at HLA-DQ enhances autoantibody production in primary Sjogren's 
      syndrome.
PG  - 1145-7
AB  - Primary Sjogren's syndrome is an autoimmune disorder characterized by dryness of 
      the mouth and eyes. The human leukocyte antigen (HLA) locus DQ is related to the 
      primary Sjogren's syndrome autoantibodies that bind the RNA proteins Ro/SSA and 
      La/SSB. Both DQ1 and DQ2 alleles are associated with high concentrations of these 
      autoantibodies. An analysis of all possible combinations at DQ has shown that the 
      entire effect was due to heterozygotes expressing the DQ1 and DQ2 alleles. These 
      data suggest that gene interaction between DQ1 and DQ2 (or alleles at associated 
      loci), possibly from gene complementation of trans-associated surface molecules, 
      influences the autoimmune response in primary Sjogren's syndrome.
FAU - Harley, J B
AU  - Harley JB
FAU - Reichlin, M
AU  - Reichlin M
FAU - Arnett, F C
AU  - Arnett FC
FAU - Alexander, E L
AU  - Alexander EL
FAU - Bias, W B
AU  - Bias WB
FAU - Provost, T T
AU  - Provost TT
LA  - eng
GR  - AM 31133/AM/NIADDK NIH HHS/United States
GR  - AM 34159/AM/NIADDK NIH HHS/United States
GR  - HL 30748/HL/NHLBI NIH HHS/United States
GR  - etc.
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Science
JT  - Science (New York, N.Y.)
JID - 0404511
RN  - 0 (Autoantibodies)
RN  - 0 (HLA-DQ Antigens)
RN  - 0 (HLA-DR Antigens)
RN  - 0 (Histocompatibility Antigens Class II)
SB  - IM
MH  - Alleles
MH  - Animals
MH  - Autoantibodies/*biosynthesis/genetics
MH  - HLA-DQ Antigens
MH  - HLA-DR Antigens
MH  - Histocompatibility Antigens Class II/*genetics/immunology
MH  - Mice
MH  - Sjogren's Syndrome/*genetics/immunology
EDAT- 1986/05/30 00:00
MHDA- 1986/05/30 00:01
CRDT- 1986/05/30 00:00
PHST- 1986/05/30 00:00 [pubmed]
PHST- 1986/05/30 00:01 [medline]
PHST- 1986/05/30 00:00 [entrez]
AID - 10.1126/science.3458307 [doi]
PST - ppublish
SO  - Science. 1986 May 30;232(4754):1145-7. doi: 10.1126/science.3458307.