PMID- 34583417
OWN - NLM
STAT- MEDLINE
DCOM- 20211203
LR  - 20211214
IS  - 1099-0496 (Electronic)
IS  - 1099-0496 (Linking)
VI  - 56
IP  - 12
DP  - 2021 Dec
TI  - Laboratory parameters between multisystem inflammatory syndrome in children and 
      Kawasaki disease.
PG  - 3688-3698
LID - 10.1002/ppul.25687 [doi]
AB  - Multisystem inflammatory syndrome in children (MIS-C) associated with coronavirus 
      disease 2019 (COVID-19) has been described to partially overlap with Kawasaki 
      disease (KD) with regard to clinical symptoms, but they are unlikely to share the 
      same disease entity. We conducted a systematic review and meta-analysis to 
      characterize the laboratory parameters of MIS-C compared with those of KD and 
      Kawasaki disease shock syndrome (KDSS). Databases were searched for studies on 
      laboratory parameters of MIS-C (hematology, inflammatory markers, cardiac 
      markers, and biochemistry) through May 31, 2021. Twelve studies with 3073 
      participants yielded 969 MIS-C patients. In terms of hematology, MIS-C patients 
      had lower levels of leukocytes, absolute lymphocyte count and platelet count 
      (PLT) than KD patients and had similar absolute neutrophil count (ANC) and 
      hemoglobin (Hb) levels. In terms of inflammatory markers, MIS-C patients had 
      higher levels of C-reactive protein, D-dimer and ferritin than KD patients and 
      had similar levels of procalcitonin and erythrocyte sedimentation rate (ESR). In 
      terms of cardiac markers, MIS-C patients had higher CPK levels than KD patients. 
      The levels of N-terminal pro-brain natriuretic peptide, troponin and aspartate 
      aminotransferase were not significantly different between MIS-C and KD patients. 
      In terms of biochemistry, MIS-C patients had lower levels of albumin, sodium and 
      alanine aminotransferase and higher levels of creatinine than KD patients. In 
      addition, MIS-C patients had lower levels of PLT, Hb and ESR and higher levels of 
      ANC than KDSS patients. Measurement of laboratory parameters might assist 
      clinicians with accurate evaluation of MIS-C and further mechanistic research.
CI  - (c) 2021 Wiley Periodicals LLC.
FAU - Zhou, Chunling
AU  - Zhou C
AD  - Department of Pediatrics, People's Hospital of Chongqing Banan District, 
      Chongqing, China.
FAU - Zhao, Yan
AU  - Zhao Y
AUID- ORCID: 0000-0002-8244-6297
AD  - Department of Pediatrics, People's Hospital of Chongqing Banan District, 
      Chongqing, China.
FAU - Wang, Xia
AU  - Wang X
AD  - Department of Pediatrics, Chongqing Youyoubaobei Women and Children's Hospital, 
      Chongqing, China.
FAU - Huang, Ying
AU  - Huang Y
AD  - Department of Respiratory Medicine, Children's Hospital of Chongqing Medical 
      University, Chongqing, China.
FAU - Tang, Xuewen
AU  - Tang X
AD  - Department of Cardiology, People's Hospital of Chongqing Banan District, 
      Chongqing, China.
FAU - Tang, Lei
AU  - Tang L
AD  - Department of Pediatrics, People's Hospital of Chongqing Banan District, 
      Chongqing, China.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Systematic Review
DEP - 20210928
PL  - United States
TA  - Pediatr Pulmonol
JT  - Pediatric pulmonology
JID - 8510590
RN  - pediatric multisystem inflammatory disease, COVID-19 related
SB  - IM
MH  - *COVID-19/complications
MH  - Child
MH  - Humans
MH  - Laboratories
MH  - *Mucocutaneous Lymph Node Syndrome/complications/diagnosis
MH  - SARS-CoV-2
MH  - Systemic Inflammatory Response Syndrome
OTO - NOTNLM
OT  - COVID-19
OT  - Kawasaki disease
OT  - Kawasaki disease shock syndrome
OT  - MIS-C
OT  - PIMS-TS
OT  - PMIS
OT  - SARS-CoV-2
OT  - children
OT  - laboratory parameters
OT  - meta-analysis
EDAT- 2021/09/29 06:00
MHDA- 2021/12/15 06:00
CRDT- 2021/09/28 20:33
PHST- 2021/08/26 00:00 [revised]
PHST- 2021/07/14 00:00 [received]
PHST- 2021/09/18 00:00 [accepted]
PHST- 2021/09/29 06:00 [pubmed]
PHST- 2021/12/15 06:00 [medline]
PHST- 2021/09/28 20:33 [entrez]
AID - 10.1002/ppul.25687 [doi]
PST - ppublish
SO  - Pediatr Pulmonol. 2021 Dec;56(12):3688-3698. doi: 10.1002/ppul.25687. Epub 2021 
      Sep 28.